메뉴 건너뛰기




Volumn 7, Issue 7, 2012, Pages

IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic Leukemia

(22)  Iacobucci, Ilaria a   Iraci, Nunzio b,h   Messina, Monica c   Lonetti, Annalisa b   Chiaretti, Sabina c   Valli, Emanuele b   Ferrari, Anna a   Papayannidis, Cristina a   Paoloni, Francesca d   Vitale, Antonella c   Storlazzi, Clelia Tiziana e   Ottaviani, Emanuela a   Guadagnuolo, Viviana a   Durante, Sandra a   Vignetti, Marco d   Soverini, Simona a   Pane, Fabrizio f   Foà, Robin c   Baccarani, Michele a   Müschen, Markus g   more..


Author keywords

[No Author keywords available]

Indexed keywords

BUB3 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2C; IKAROS TRANSCRIPTION FACTOR; JANUS KINASE; PROTEIN MCL 1; PROTEIN MSH2; STAT PROTEIN; TRANSCRIPTION FACTOR ETV6;

EID: 84864368299     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040934     Document Type: Article
Times cited : (73)

References (43)
  • 1
    • 27244440324 scopus 로고    scopus 로고
    • Molecular genetics of acute lymphoblastic leukemia
    • Armstrong SA, Look AT, (2005) Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol 23: 6306-6315.
    • (2005) J Clin Oncol , vol.23 , pp. 6306-6315
    • Armstrong, S.A.1    Look, A.T.2
  • 2
    • 0037610972 scopus 로고    scopus 로고
    • Molecular genetic events in adult acute lymphoblastic leukemia
    • Gleissner B, Thiel E, (2003) Molecular genetic events in adult acute lymphoblastic leukemia. Expert Rev Mol Diagn 3: 339-355.
    • (2003) Expert Rev Mol Diagn , vol.3 , pp. 339-355
    • Gleissner, B.1    Thiel, E.2
  • 4
    • 34147135183 scopus 로고    scopus 로고
    • Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    • Moorman AV, Harrison CJ, Buck GA, Richards SM, Secker-Walker LM, et al. (2007) Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood 109: 3189-3197.
    • (2007) Blood , vol.109 , pp. 3189-3197
    • Moorman, A.V.1    Harrison, C.J.2    Buck, G.A.3    Richards, S.M.4    Secker-Walker, L.M.5
  • 5
    • 58149394484 scopus 로고    scopus 로고
    • Integration of genomic and gene expression data of childhood ALL without known aberrations identifies subgroups with specific genetic hallmarks
    • Bungaro S, Dell'Orto MC, Zangrando A, Basso D, Gorletta T, et al. (2009) Integration of genomic and gene expression data of childhood ALL without known aberrations identifies subgroups with specific genetic hallmarks. Genes Chromosomes Cancer 48: 22-38.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 22-38
    • Bungaro, S.1    Dell'Orto, M.C.2    Zangrando, A.3    Basso, D.4    Gorletta, T.5
  • 6
    • 34147224008 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
    • Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, et al. (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446: 758-764.
    • (2007) Nature , vol.446 , pp. 758-764
    • Mullighan, C.G.1    Goorha, S.2    Radtke, I.3    Miller, C.B.4    Coustan-Smith, E.5
  • 7
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, et al. (2008) BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453: 110-114.
    • (2008) Nature , vol.453 , pp. 110-114
    • Mullighan, C.G.1    Miller, C.B.2    Radtke, I.3    Phillips, L.A.4    Dalton, J.5
  • 8
    • 38349177862 scopus 로고    scopus 로고
    • Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    • Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, et al. (2008) Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 111: 776-784.
    • (2008) Blood , vol.111 , pp. 776-784
    • Kawamata, N.1    Ogawa, S.2    Zimmermann, M.3    Kato, M.4    Sanada, M.5
  • 9
    • 57549097632 scopus 로고    scopus 로고
    • Global genomic characterization of acute lymphoblastic leukemia
    • Mullighan CG, Downing JR, (2009) Global genomic characterization of acute lymphoblastic leukemia. Semin Hematol 46: 3-15.
    • (2009) Semin Hematol , vol.46 , pp. 3-15
    • Mullighan, C.G.1    Downing, J.R.2
  • 10
    • 50149109824 scopus 로고    scopus 로고
    • Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray
    • Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, et al. (2008) Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. Proc Natl Acad Sci U S A 105: 11921-11926.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11921-11926
    • Kawamata, N.1    Ogawa, S.2    Zimmermann, M.3    Niebuhr, B.4    Stocking, C.5
  • 11
    • 70349242044 scopus 로고    scopus 로고
    • Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
    • Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, et al. (2009) Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 114: 2159-2167.
    • (2009) Blood , vol.114 , pp. 2159-2167
    • Iacobucci, I.1    Storlazzi, C.T.2    Cilloni, D.3    Lonetti, A.4    Ottaviani, E.5
  • 12
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, et al. (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79: 143-156.
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3    Molnar, A.4    Wu, P.5
  • 13
    • 0028866897 scopus 로고
    • A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
    • Winandy S, Wu P, Georgopoulos K, (1995) A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83: 289-299.
    • (1995) Cell , vol.83 , pp. 289-299
    • Winandy, S.1    Wu, P.2    Georgopoulos, K.3
  • 14
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    • Georgopoulos K, (2002) Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2: 162-174.
    • (2002) Nat Rev Immunol , vol.2 , pp. 162-174
    • Georgopoulos, K.1
  • 16
    • 70449719091 scopus 로고    scopus 로고
    • IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report
    • Martinelli G, Iacobucci I, Storlazzi CT, Vignetti M, Paoloni F, et al. (2009) IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 27: 5202-5207.
    • (2009) J Clin Oncol , vol.27 , pp. 5202-5207
    • Martinelli, G.1    Iacobucci, I.2    Storlazzi, C.T.3    Vignetti, M.4    Paoloni, F.5
  • 17
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, et al. (2009) Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360: 470-480.
    • (2009) N Engl J Med , vol.360 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3    Radtke, I.4    Phillips, L.A.5
  • 18
    • 47849118209 scopus 로고    scopus 로고
    • Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
    • Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, et al. (2008) Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol 9: 927-936.
    • (2008) Nat Immunol , vol.9 , pp. 927-936
    • Reynaud, D.1    Demarco, I.A.2    Reddy, K.L.3    Schjerven, H.4    Bertolino, E.5
  • 19
    • 46749117575 scopus 로고    scopus 로고
    • Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
    • Kano G, Morimoto A, Takanashi M, Hibi S, Sugimoto T, et al. (2008) Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels. Leuk Lymphoma 49: 965-973.
    • (2008) Leuk Lymphoma , vol.49 , pp. 965-973
    • Kano, G.1    Morimoto, A.2    Takanashi, M.3    Hibi, S.4    Sugimoto, T.5
  • 21
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM, (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 22
    • 0028019274 scopus 로고
    • The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
    • Molnar A, Georgopoulos K, (1994) The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 14: 8292-8303.
    • (1994) Mol Cell Biol , vol.14 , pp. 8292-8303
    • Molnar, A.1    Georgopoulos, K.2
  • 23
    • 0031907815 scopus 로고    scopus 로고
    • Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
    • Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, et al. (1998) Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc Natl Acad Sci U S A 95: 657-662.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 657-662
    • Klug, C.A.1    Morrison, S.J.2    Masek, M.3    Hahm, K.4    Smale, S.T.5
  • 25
    • 0030498975 scopus 로고    scopus 로고
    • Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
    • Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, et al. (1996) Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5: 537-549.
    • (1996) Immunity , vol.5 , pp. 537-549
    • Wang, J.H.1    Nichogiannopoulou, A.2    Wu, L.3    Sun, L.4    Sharpe, A.H.5
  • 27
    • 34249733805 scopus 로고    scopus 로고
    • High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
    • Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, et al. (2007) High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 21: 1258-1266.
    • (2007) Leukemia , vol.21 , pp. 1258-1266
    • Kuiper, R.P.1    Schoenmakers, E.F.2    van Reijmersdal, S.V.3    Hehir-Kwa, J.Y.4    van Kessel, A.G.5
  • 28
    • 69849112542 scopus 로고    scopus 로고
    • Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia
    • Copland M, (2009) Ikaros deletions are associated with poor prognosis in acute lymphoblastic leukemia. Future Oncol 5: 455-458.
    • (2009) Future Oncol , vol.5 , pp. 455-458
    • Copland, M.1
  • 29
    • 64049102658 scopus 로고    scopus 로고
    • Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
    • Ng SY, Yoshida T, Zhang J, Georgopoulos K, (2009) Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 30: 493-507.
    • (2009) Immunity , vol.30 , pp. 493-507
    • Ng, S.Y.1    Yoshida, T.2    Zhang, J.3    Georgopoulos, K.4
  • 30
    • 58749097408 scopus 로고    scopus 로고
    • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study
    • Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JG, et al. (2009) A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 10: 125-134.
    • (2009) Lancet Oncol , vol.10 , pp. 125-134
    • Den Boer, M.L.1    van Slegtenhorst, M.2    De Menezes, R.X.3    Cheok, M.H.4    Buijs-Gladdines, J.G.5
  • 31
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, et al. (2008) Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 9: 203-215.
    • (2008) Nat Immunol , vol.9 , pp. 203-215
    • Pongubala, J.M.1    Northrup, D.L.2    Lancki, D.W.3    Medina, K.L.4    Treiber, T.5
  • 32
    • 0041440074 scopus 로고    scopus 로고
    • Repopulating defect of mismatch repair-deficient hematopoietic stem cells
    • Reese JS, Liu L, Gerson SL, (2003) Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 102: 1626-1633.
    • (2003) Blood , vol.102 , pp. 1626-1633
    • Reese, J.S.1    Liu, L.2    Gerson, S.L.3
  • 33
    • 58149236959 scopus 로고    scopus 로고
    • Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
    • Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, et al. (2009) Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 457: 51-56.
    • (2009) Nature , vol.457 , pp. 51-56
    • Viale, A.1    De Franco, F.2    Orleth, A.3    Cambiaghi, V.4    Giuliani, V.5
  • 34
    • 73349093391 scopus 로고    scopus 로고
    • Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros
    • Papathanasiou P, Attema JL, Karsunky H, Hosen N, Sontani Y, et al. (2009) Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cells 27: 3082-3092.
    • (2009) Stem Cells , vol.27 , pp. 3082-3092
    • Papathanasiou, P.1    Attema, J.L.2    Karsunky, H.3    Hosen, N.4    Sontani, Y.5
  • 35
    • 68149098480 scopus 로고    scopus 로고
    • Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function
    • Trageser D, Iacobucci I, Nahar R, Duy C, von Levetzow G, et al. (2009) Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med 206: 1739-1753.
    • (2009) J Exp Med , vol.206 , pp. 1739-1753
    • Trageser, D.1    Iacobucci, I.2    Nahar, R.3    Duy, C.4    von Levetzow, G.5
  • 36
    • 84860839901 scopus 로고    scopus 로고
    • Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
    • Waanders E, van der Velden VH, van der Schoot CE, van Leeuwen FN, van Reijmersdal SV, et al. (2010) Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia.
    • (2010) Leukemia
    • Waanders, E.1    van der Velden, V.H.2    van der Schoot, C.E.3    van Leeuwen, F.N.4    van Reijmersdal, S.V.5
  • 37
    • 84859210533 scopus 로고    scopus 로고
    • Minimal Residual Disease At 3 Months, Combined to the Presence of IKZF1 Deletion in B-Lineage or Absence of NOTCH1 pathway Mutation in T-Lineage, Recapitulates the Disease Risk Assessment in Adults with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia - A GRAALL Study
    • Beldjord K, Macintyre E, Lhéritier V, Boulland ML, Leguay T, et al. (2011) Minimal Residual Disease At 3 Months, Combined to the Presence of IKZF1 Deletion in B-Lineage or Absence of NOTCH1 pathway Mutation in T-Lineage, Recapitulates the Disease Risk Assessment in Adults with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia- A GRAALL Study. Blood (ASH Annual Meeting Abstracts) 118: 572.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 572
    • Beldjord, K.1    Macintyre, E.2    Lhéritier, V.3    Boulland, M.L.4    Leguay, T.5
  • 38
    • 77957796750 scopus 로고    scopus 로고
    • The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party
    • Iacobucci I, Lonetti A, Paoloni F, Papayannidis C, Ferrari A, et al. (2010) The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party. Haematologica 95: 1683-1690.
    • (2010) Haematologica , vol.95 , pp. 1683-1690
    • Iacobucci, I.1    Lonetti, A.2    Paoloni, F.3    Papayannidis, C.4    Ferrari, A.5
  • 39
    • 77952097046 scopus 로고    scopus 로고
    • Gene expression profile of protein kinases reveals a distinctive signature in chronic lymphocytic leukemia and in vitro experiments support a role of second generation protein kinase inhibitors
    • Tavolaro S, Chiaretti S, Messina M, Peragine N, Del Giudice I, et al. (2010) Gene expression profile of protein kinases reveals a distinctive signature in chronic lymphocytic leukemia and in vitro experiments support a role of second generation protein kinase inhibitors. Leuk Res 34: 733-741.
    • (2010) Leuk Res , vol.34 , pp. 733-741
    • Tavolaro, S.1    Chiaretti, S.2    Messina, M.3    Peragine, N.4    Del Giudice, I.5
  • 40
    • 77955134007 scopus 로고    scopus 로고
    • Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group
    • Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, et al. (2010) Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 28: 2529-2537.
    • (2010) J Clin Oncol , vol.28 , pp. 2529-2537
    • Haferlach, T.1    Kohlmann, A.2    Wieczorek, L.3    Basso, G.4    Kronnie, G.T.5
  • 41
    • 0035793042 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
    • Li C, Wong WH, (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 98: 31-36.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 31-36
    • Li, C.1    Wong, W.H.2
  • 42
  • 43
    • 55849099654 scopus 로고    scopus 로고
    • Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
    • Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, et al. (2008) Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A 105: 16224-16229.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16224-16229
    • Leary, R.J.1    Lin, J.C.2    Cummins, J.3    Boca, S.4    Wood, L.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.