Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 8, 2012, Pages 1279-1289

  Yan, Shunchao ^a   Qu, Xiujuan ^a   Xu, Chong'An ^a   Zhu, Zhitu ^b   Zhang, Lingyun ^a   Xu, Ling ^a   Song, Na ^a   Teng, Yuee ^a   Liu, Yunpeng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Bufalin; Cbl b; Death receptor; TRAIL

Indexed keywords

BUFALIN; CBL B PROTEIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; LIGASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; BUFANOLIDES; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864359162     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1204-4     Document Type: Article

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