ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages 11999-12004

  Lyubimov, Artem Y ^a   Costa, Alessandro ^b   Bleichert, Franziska ^a,c   Botchan, Michael R ^a   Berger, James M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATP hydrolysis; DNA replication; Helicase activation; Helicase loading; Structural dynamics

Indexed keywords

ADENOSINE TRIPHOSPHATE; HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 2; MINICHROMOSOME MAINTENANCE PROTEIN 3; MINICHROMOSOME MAINTENANCE PROTEIN 4; MINICHROMOSOME MAINTENANCE PROTEIN 5; MINICHROMOSOME MAINTENANCE PROTEIN 6; MINICHROMOSOME MAINTENANCE PROTEIN 7; NUCLEOTIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENCEPHALITOZOON CUNICULI; ENZYME ACTIVITY; EUKARYOTE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; DNA HELICASES; DNA-BINDING PROTEINS; ENCEPHALITOZOON CUNICULI; ENZYME ACTIVATION; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE;

ENCEPHALITOZOON CUNICULI; EUKARYOTA;

EID: 84864352599     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209406109     Document Type: Article

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