-
1
-
-
67849118814
-
Genotype/phenotype association in von Willebrand disease: Is the glass half full or empty?
-
Lillicrap D. Genotype/phenotype association in von Willebrand disease: is the glass half full or empty? J Thromb Haemost 2009; 7 (Suppl 1): 65-70.
-
(2009)
J Thromb Haemost
, vol.7
, Issue.SUPPL. 1
, pp. 65-70
-
-
Lillicrap, D.1
-
2
-
-
33748802581
-
Update on the pathophysiology and classification of von Willebrand disease: A report of the Subcommittee on von Willebrand Factor
-
Sadler JE, Budde U, Eikenboom JC, et al. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor. J Thromb Haemost 2006; 4: 2103-2114.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 2103-2114
-
-
Sadler, J.E.1
Budde, U.2
Eikenboom, J.C.3
-
3
-
-
33846445722
-
Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13
-
Rayes J, Hommais A, Legendre P, et al. Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand factor to ADAMTS-13. J Thromb Haemost 2007; 5: 321-328.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 321-328
-
-
Rayes, J.1
Hommais, A.2
Legendre, P.3
-
4
-
-
0022517442
-
Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE)
-
Zimmerman TS, Dent JA, Ruggeri ZM, et al. Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE). J Clin Invest 1986; 77: 947-951.
-
(1986)
J Clin Invest
, vol.77
, pp. 947-951
-
-
Zimmerman, T.S.1
Dent, J.A.2
Ruggeri, Z.M.3
-
5
-
-
60249092963
-
Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: A cohort study of 67 patients
-
Federici AB, Mannucci PM, Castaman G, et al. Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients. Blood 2009; 113: 526-534.
-
(2009)
Blood
, vol.113
, pp. 526-534
-
-
Federici, A.B.1
Mannucci, P.M.2
Castaman, G.3
-
6
-
-
77749298357
-
Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics
-
Becker RC, Povsic T, Cohen MG, et al. Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics. Thromb Haemost 2010; 103: 586-595.
-
(2010)
Thromb Haemost
, vol.103
, pp. 586-595
-
-
Becker, R.C.1
Povsic, T.2
Cohen, M.G.3
-
7
-
-
70350705718
-
A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1
-
Huang RH, Fremont DH, Diener JL, et al. A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure 2009; 17: 1476-1484.
-
(2009)
Structure
, vol.17
, pp. 1476-1484
-
-
Huang, R.H.1
Fremont, D.H.2
Diener, J.L.3
-
8
-
-
37349040378
-
First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers
-
Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, et al. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 2007; 116: 2678-2686.
-
(2007)
Circulation
, vol.116
, pp. 2678-2686
-
-
Gilbert, J.C.1
DeFeo-Fraulini, T.2
Hutabarat, R.M.3
-
9
-
-
67649518156
-
Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779
-
Diener JL, Daniel Lagasse HA, Duerschmied D, et al. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost 2009; 7: 1155-1162.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 1155-1162
-
-
Diener, J.L.1
Daniel Lagasse, H.A.2
Duerschmied, D.3
-
10
-
-
76549094772
-
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases
-
Siller-Matula JM, Krumphuber J, Jilma B. Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol 2009; 159: 502-517.
-
(2009)
Br J Pharmacol
, vol.159
, pp. 502-517
-
-
Siller-Matula, J.M.1
Krumphuber, J.2
Jilma, B.3
-
11
-
-
77956633476
-
A randomised pilot trial of the antivon Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease
-
Jilma B, Paulinska P, Jilma-Stohlawetz P, et al. A randomised pilot trial of the antivon Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease. Thromb Haemost 2010; 104: 563-570.
-
(2010)
Thromb Haemost
, vol.104
, pp. 563-570
-
-
Jilma, B.1
Paulinska, P.2
Jilma-Stohlawetz, P.3
-
12
-
-
0019958149
-
Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: Implications for pathophysiology and therapy of von Willebrand's disease subtypes
-
Ruggeri ZM, Mannucci PM, Lombardi R, et al. Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes. Blood 1982; 59: 1272-1278.
-
(1982)
Blood
, vol.59
, pp. 1272-1278
-
-
Ruggeri, Z.M.1
Mannucci, P.M.2
Lombardi, R.3
-
13
-
-
78649725668
-
Prospective study of low-dose ristocetin-induced platelet aggregation to identify type 2B von Willebrand disease (VWD) and platelet-type VWD in children
-
Frontroth JP, Hepner M, Sciuccati G, et al. Prospective study of low-dose ristocetin-induced platelet aggregation to identify type 2B von Willebrand disease (VWD) and platelet-type VWD in children. Thromb Haemost 2010; 104: 1158-1165.
-
(2010)
Thromb Haemost
, vol.104
, pp. 1158-1165
-
-
Frontroth, J.P.1
Hepner, M.2
Sciuccati, G.3
-
14
-
-
68649114583
-
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction
-
Spiel AO, Mayr FB, Ladani N, et al. The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. Platelets 2009; 20: 334-340.
-
(2009)
Platelets
, vol.20
, pp. 334-340
-
-
Spiel, A.O.1
Mayr, F.B.2
Ladani, N.3
-
15
-
-
80052350022
-
A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura
-
Jilma-Stohlawetz P, Gilbert JC, Gorczyca ME, et al. A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura. Thromb Haemost 2011; 106: 539-547.
-
(2011)
Thromb Haemost
, vol.106
, pp. 539-547
-
-
Jilma-Stohlawetz, P.1
Gilbert, J.C.2
Gorczyca, M.E.3
-
16
-
-
68649126744
-
Anti-von Willebrand factor aptamer ARC1779 for refractory thrombotic thrombocytopenic purpura
-
Knobl P, Jilma B, Gilbert JC, et al. Anti-von Willebrand factor aptamer ARC1779 for refractory thrombotic thrombocytopenic purpura. Transfusion 2009; 49: 2181-2185.
-
(2009)
Transfusion
, vol.49
, pp. 2181-2185
-
-
Knobl, P.1
Jilma, B.2
Gilbert, J.C.3
-
17
-
-
0345167849
-
Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin
-
Reiter RA, Mayr F, Blazicek H, et al. Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin. Blood 2003; 102: 4594-4599.
-
(2003)
Blood
, vol.102
, pp. 4594-4599
-
-
Reiter, R.A.1
Mayr, F.2
Blazicek, H.3
-
18
-
-
0034867946
-
Platelet function analyzer (PFA-100): A tool to quantify congenital or acquired platelet dysfunction
-
Jilma B. Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunction. J Lab Clin Med 2001; 138: 152-163.
-
(2001)
J Lab Clin Med
, vol.138
, pp. 152-163
-
-
Jilma, B.1
-
20
-
-
22144455398
-
The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults
-
Harrison P. The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults. Br J Haematol 2005; 130: 3-10.
-
(2005)
Br J Haematol
, vol.130
, pp. 3-10
-
-
Harrison, P.1
-
21
-
-
79955370074
-
Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration. A randomised controlled trial
-
Spiel AO, Bartko J, Schwameis M, et al. Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration. A randomised controlled trial. Thromb Haemost 2011; 105: 655-662.
-
(2011)
Thromb Haemost
, vol.105
, pp. 655-662
-
-
Spiel, A.O.1
Bartko, J.2
Schwameis, M.3
-
22
-
-
15344341949
-
Changes in ADAMTS13 (von-Willebrandfactor-cleaving protease) activity after induced release of von Willebrand factor during acute systemic inflammation
-
Reiter RA, Varadi K, Turecek PL, et al. Changes in ADAMTS13 (von-Willebrandfactor-cleaving protease) activity after induced release of von Willebrand factor during acute systemic inflammation. Thromb Haemost 2005; 93: 554-558.
-
(2005)
Thromb Haemost
, vol.93
, pp. 554-558
-
-
Reiter, R.A.1
Varadi, K.2
Turecek, P.L.3
-
23
-
-
33645561781
-
Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans
-
Spiel AO, Mayr FB, Firbas C, et al. Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans. J Thromb Haemost 2006; 4: 411-416.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 411-416
-
-
Spiel, A.O.1
Mayr, F.B.2
Firbas, C.3
-
24
-
-
79958803279
-
Safety of a universal, virus-inactivated and prion-depleted, pharmaceutical-quality plasma: A randomized, double-blind, clinical trial in healthy volunteers
-
Jilma-Stohlawetz P, Kursten FW, Walasek C, et al. Safety of a universal, virus-inactivated and prion-depleted, pharmaceutical-quality plasma: a randomized, double-blind, clinical trial in healthy volunteers. Transfusion 2011; 51: 1228-1240.
-
(2011)
Transfusion
, vol.51
, pp. 1228-1240
-
-
Jilma-Stohlawetz, P.1
Kursten, F.W.2
Walasek, C.3
-
25
-
-
77955015583
-
Massive pulmonary embolism leading to cardiac arrest is associated with consumptive coagulopathy presenting as disseminated intravascular coagulation
-
Leitner JM, Jilma B, Spiel AO, et al. Massive pulmonary embolism leading to cardiac arrest is associated with consumptive coagulopathy presenting as disseminated intravascular coagulation. J Thromb Haemost 2010; 8: 1477-1482.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 1477-1482
-
-
Leitner, J.M.1
Jilma, B.2
Spiel, A.O.3
-
26
-
-
0031595454
-
Comparison between von Willebrand factor (VWF) and VWF antigen II in normal individuals and patients with von Willebrand disease
-
de Romeuf C, Mazurier C. Comparison between von Willebrand factor (VWF) and VWF antigen II in normal individuals and patients with von Willebrand disease. Thromb Haemost 1998; 80: 37-41.
-
(1998)
Thromb Haemost
, vol.80
, pp. 37-41
-
-
de Romeuf, C.1
Mazurier, C.2
-
27
-
-
33746650150
-
The utility of the PFA-100 in the identification of von Willebrand disease: A concise review
-
Favaloro EJ. The utility of the PFA-100 in the identification of von Willebrand disease: a concise review. Semin Thromb Hemost 2006; 32: 537-545.
-
(2006)
Semin Thromb Hemost
, vol.32
, pp. 537-545
-
-
Favaloro, E.J.1
-
28
-
-
77951679429
-
The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo
-
Mayr FB, Knobl P, Jilma B, et al. The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo. Transfusion 2010; 50: 1079-1087.
-
(2010)
Transfusion
, vol.50
, pp. 1079-1087
-
-
Mayr, F.B.1
Knobl, P.2
Jilma, B.3
-
29
-
-
79952505304
-
Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura
-
Jilma-Stohlawetz P, Gorczyca ME, Jilma B, et al. Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura. Thromb Haemost 2011; 105: 545-552.
-
(2011)
Thromb Haemost
, vol.105
, pp. 545-552
-
-
Jilma-Stohlawetz, P.1
Gorczyca, M.E.2
Jilma, B.3
-
30
-
-
0033858187
-
Impact, diagnosis and treatment of von Willebrand disease
-
Sadler JE, Mannucci PM, Berntorp E, et al. Impact, diagnosis and treatment of von Willebrand disease. Thromb Haemost 2000; 84: 160-174.
-
(2000)
Thromb Haemost
, vol.84
, pp. 160-174
-
-
Sadler, J.E.1
Mannucci, P.M.2
Berntorp, E.3
-
31
-
-
77956021805
-
Reduced survival of type 2B von Willebrand factor, irrespective of large multimer representation or thrombocytopenia
-
Casonato A, Gallinaro L, Cattini MG, et al. Reduced survival of type 2B von Willebrand factor, irrespective of large multimer representation or thrombocytopenia. Haematologica 2010; 95: 1366-1372.
-
(2010)
Haematologica
, vol.95
, pp. 1366-1372
-
-
Casonato, A.1
Gallinaro, L.2
Cattini, M.G.3
-
32
-
-
0022504431
-
Inducible secretion of large, biologically potent von Willebrand factor multimers
-
Sporn LA, Marder VJ, Wagner DD. Inducible secretion of large, biologically potent von Willebrand factor multimers. Cell 1986; 46: 185-190.
-
(1986)
Cell
, vol.46
, pp. 185-190
-
-
Sporn, L.A.1
Marder, V.J.2
Wagner, D.D.3
-
33
-
-
0026001694
-
The high molecular weight form of endothelial cell von Willebrand factor is released by the regulated pathway
-
Tsai HM, Nagel RL, Hatcher VB, et al. The high molecular weight form of endothelial cell von Willebrand factor is released by the regulated pathway. Br J Haematol 1991; 79: 239-245.
-
(1991)
Br J Haematol
, vol.79
, pp. 239-245
-
-
Tsai, H.M.1
Nagel, R.L.2
Hatcher, V.B.3
-
34
-
-
45549087119
-
Basal secretion of von Willebrand factor from human endothelial cells
-
Giblin JP, Hewlett LJ, Hannah MJ. Basal secretion of von Willebrand factor from human endothelial cells. Blood 2008; 112: 957-964.
-
(2008)
Blood
, vol.112
, pp. 957-964
-
-
Giblin, J.P.1
Hewlett, L.J.2
Hannah, M.J.3
-
35
-
-
44049113010
-
Protein sorting and secretion granule formation in regulated secretory cells
-
Arvan P, Castle D. Protein sorting and secretion granule formation in regulated secretory cells. Trends Cell Biol 1992; 2: 327-331.
-
(1992)
Trends Cell Biol
, vol.2
, pp. 327-331
-
-
Arvan, P.1
Castle, D.2
-
36
-
-
34547840334
-
Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells
-
Erent M, Meli A, Moisoi N, et al. Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells. J Physiol 2007; 583: 195-212.
-
(2007)
J Physiol
, vol.583
, pp. 195-212
-
-
Erent, M.1
Meli, A.2
Moisoi, N.3
-
38
-
-
33645550656
-
Antiviral therapy decreases GpIIb/IIIa activation of platelets in patients with chronic hepatitis C
-
Sieghart W, Homoncik M, Jilma B, et al. Antiviral therapy decreases GpIIb/IIIa activation of platelets in patients with chronic hepatitis C. Thromb Haemost 2006; 95: 260-266.
-
(2006)
Thromb Haemost
, vol.95
, pp. 260-266
-
-
Sieghart, W.1
Homoncik, M.2
Jilma, B.3
-
39
-
-
33749176563
-
Erythropoietin treatment is associated with more severe thrombocytopenia in patients with chronic hepatitis C undergoing antiviral therapy
-
Homoncik M, Sieghart W, Formann E, et al. Erythropoietin treatment is associated with more severe thrombocytopenia in patients with chronic hepatitis C undergoing antiviral therapy. Am J Gastroenterol 2006; 101: 2275-2282.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 2275-2282
-
-
Homoncik, M.1
Sieghart, W.2
Formann, E.3
-
40
-
-
77954771607
-
Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia
-
Derhaschnig U, Schweeger-Exeli I, Marsik C, et al. Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia. Platelets 2010; 215: 320-328.
-
(2010)
Platelets
, vol.215
, pp. 320-328
-
-
Derhaschnig, U.1
Schweeger-Exeli, I.2
Marsik, C.3
-
41
-
-
0034488936
-
Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100
-
Homoncik M, Blann AD, Hollenstein U, et al. Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100. Br J Haematol 2000; 111: 1250-1252.
-
(2000)
Br J Haematol
, vol.111
, pp. 1250-1252
-
-
Homoncik, M.1
Blann, A.D.2
Hollenstein, U.3
-
42
-
-
78649677591
-
Targeting von Willebrand factor and platelet glycoprotein Ib receptor
-
Firbas C, Siller-Matula JM, Jilma B. Targeting von Willebrand factor and platelet glycoprotein Ib receptor. Expert Rev Cardiovasc Ther 2010; 8: 1689-1701.
-
(2010)
Expert Rev Cardiovasc Ther
, vol.8
, pp. 1689-1701
-
-
Firbas, C.1
Siller-Matula, J.M.2
Jilma, B.3
-
43
-
-
84858690837
-
ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion
-
Siller-Matula JM, Merhi Y, Tanguay JF, et al. ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion. Arterioscler Thromb Vasc Biol 2012; 32: 902-909.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 902-909
-
-
Siller-Matula, J.M.1
Merhi, Y.2
Tanguay, J.F.3
-
44
-
-
79952525129
-
Frequency of platelet type versus type 2B von Willebrand disease. An international registry-based study
-
Hamilton A, Ozelo M, Leggo J, et al. Frequency of platelet type versus type 2B von Willebrand disease. An international registry-based study. Thromb Haemost 2011; 105: 501-508.
-
(2011)
Thromb Haemost
, vol.105
, pp. 501-508
-
-
Hamilton, A.1
Ozelo, M.2
Leggo, J.3
|