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Volumn 95, Issue 8, 2010, Pages 1366-1372

Reduced survival of type 2B von willebrand factor, irrespective of large multimer representation or thrombocytopenia

Author keywords

Large VWF multimers; Type 2B thrombocytopenia; Type 2B VWD; Von willebrand factor; VWF half life

Indexed keywords

COLLAGEN; DESMOPRESSIN; GLYCOPROTEIN IB; VON WILLEBRAND FACTOR;

EID: 77956021805     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.019927     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 0031686041 scopus 로고    scopus 로고
    • Biochemistry and genetics of von Willebrand factor
    • Sadler JE. Biochemistry and genetics of von Willebrand factor. Ann Rev Biochem. 1998;67:395-424.
    • (1998) Ann Rev Biochem , vol.67 , pp. 395-424
    • Sadler, J.E.1
  • 2
    • 0037369110 scopus 로고    scopus 로고
    • Von Willebrand factor
    • Ruggeri ZM. Von Willebrand factor. Curr Opin Hematol. 2003;10(2):142-9.
    • (2003) Curr Opin Hematol , vol.10 , Issue.2 , pp. 142-149
    • Ruggeri, Z.M.1
  • 3
    • 0019496229 scopus 로고
    • Effect of multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets
    • Gralnick HR, Williams SB, Morisato DK. Effect of multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets. Blood. 1981;58(2):387-97.
    • (1981) Blood , vol.58 , Issue.2 , pp. 387-397
    • Gralnick, H.R.1    Williams, S.B.2    Morisato, D.K.3
  • 4
    • 0035798582 scopus 로고    scopus 로고
    • Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura
    • Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem. 2001;276(44):41059-63.
    • (2001) J Biol Chem , vol.276 , Issue.44 , pp. 41059-41063
    • Zheng, X.1    Chung, D.2    Takayama, T.K.3    Majerus, E.M.4    Sadler, J.E.5    Fujikawa, K.6
  • 5
    • 0026069774 scopus 로고
    • Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit
    • Dent JA, Galbusera M, Ruggeri ZM. Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit. J Clin Invest. 1991;88(33):774-82.
    • (1991) J Clin Invest , vol.88 , Issue.33 , pp. 774-782
    • Dent, J.A.1    Galbusera, M.2    Ruggeri, Z.M.3
  • 6
    • 0037158606 scopus 로고    scopus 로고
    • Thrombotic microangiopathies
    • Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002;347(8):589-600.
    • (2002) N Engl J Med , vol.347 , Issue.8 , pp. 589-600
    • Moake, J.L.1
  • 7
    • 0025044664 scopus 로고
    • Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor
    • Dent JA, Berkowitz SD, Ware J, Kasper CK, Ruggeri ZM. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor. Proc Natl Acad Sci USA. 1990;87(16):6306-10.
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.16 , pp. 6306-6310
    • Dent, J.A.1    Berkowitz, S.D.2    Ware, J.3    Kasper, C.K.4    Ruggeri, Z.M.5
  • 8
    • 0023612519 scopus 로고
    • Von Willebrand factor and von Willebrand disease
    • Ruggeri ZM, Zimmerman TS. Von Willebrand factor and von Willebrand disease. Blood. 1987;70(4):895-904.
    • (1987) Blood , vol.70 , Issue.4 , pp. 895-904
    • Ruggeri, Z.M.1    Zimmerman, T.S.2
  • 9
    • 33748802581 scopus 로고    scopus 로고
    • Working Party on von Willebrand disease classification. Update on the pathophysiology and classification of von Willebrand disease: A report of the Subcommittee on von Willebrand factor
    • Sadler JE, Budde U, Eikenboom CJ, Favaloro EJ, Hill FG, Holmberg L, et al.; Working Party on von Willebrand disease classification. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand factor. J Thromb Haemost. 2006;4(10):2103-14.
    • (2006) J Thromb Haemost , vol.4 , Issue.10 , pp. 2103-2114
    • Sadler, J.E.1    Budde, U.2    Eikenboom, C.J.3    Favaloro, E.J.4    Hill, F.G.5    Holmberg, L.6
  • 10
    • 0018871618 scopus 로고
    • Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease
    • Ruggeri ZM, Pareti FI, Mannucci PM, Ciavarella N, Zimmerman TS. Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease. N Engl J Med. 1980;302(19):1047-51.
    • (1980) N Engl J Med , vol.302 , Issue.19 , pp. 1047-1051
    • Ruggeri, Z.M.1    Pareti, F.I.2    Mannucci, P.M.3    Ciavarella, N.4    Zimmerman, T.S.5
  • 11
    • 4444278190 scopus 로고    scopus 로고
    • Type IIB von Willebrand disease: A paradox explains how von Willebrand factor works
    • Ruggeri ZM. Type IIB von Willebrand disease: a paradox explains how von Willebrand factor works. J Thromb Haemost. 2004;2(1):2-6.
    • (2004) J Thromb Haemost , vol.2 , Issue.1 , pp. 2-6
    • Ruggeri, Z.M.1
  • 12
    • 0025732427 scopus 로고
    • Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences
    • Randi AM, Rabinowitz I, Mancuso DJ, Mannucci PM, Sadler JE. Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences. J Clin Invest. 1991; 87(4):1220-6.
    • (1991) J Clin Invest , vol.87 , Issue.4 , pp. 1220-1226
    • Randi, A.M.1    Rabinowitz, I.2    Mancuso, D.J.3    Mannucci, P.M.4    Sadler, J.E.5
  • 13
    • 0034962013 scopus 로고    scopus 로고
    • Type 2B von Willebrand's disease due to Val1316Met mutation. Heterogeneity in the same sibship
    • Rendal E, Penas N, Larrabeiti B, Pérez A, Vale A, Lopez-Fernandez MF, et al. Type 2B von Willebrand's disease due to Val1316Met mutation. Heterogeneity in the same sibship. Ann Hematol. 2001; 80(6):354-60.
    • (2001) Ann Hematol , vol.80 , Issue.6 , pp. 354-360
    • Rendal, E.1    Penas, N.2    Larrabeiti, B.3    Pérez, A.4    Vale, A.5    Lopez-Fernandez, M.F.6
  • 14
    • 0022379622 scopus 로고
    • Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor
    • Gralnick HR, Williams SB, McKeown LP, Rick ME, Maisonneuve P, Jenneau C, et al. Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor. J Clin Invest. 1985;76(4):1522-9.
    • (1985) J Clin Invest , vol.76 , Issue.4 , pp. 1522-1529
    • Gralnick, H.R.1    Williams, S.B.2    McKeown, L.P.3    Rick, M.E.4    Maisonneuve, P.5    Jenneau, C.6
  • 15
    • 0023392677 scopus 로고
    • Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors
    • De Marco L, Mazzucato M, Grazia Del Ben M, Budde U, Federici AB, Girolami A, et al. Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors. J Clin Invest. 1987;80(2):475-82.
    • (1987) J Clin Invest , vol.80 , Issue.2 , pp. 475-482
    • de Marco, L.1    Mazzucato, M.2    del Ben, G.M.3    Budde, U.4    Federici, A.B.5    Girolami, A.6
  • 16
    • 0022539610 scopus 로고
    • A new von Willebrand factor variant (type I, New York): Increased ristocetin-induced platelet aggregation and plasma von Willebrand factor containing the full complement of multimers
    • Weiss HJ, Sussman II. A new von Willebrand factor variant (type I, New York): increased ristocetin-induced platelet aggregation and plasma von Willebrand factor containing the full complement of multimers. Blood. 1986;68(1):149-56.
    • (1986) Blood , vol.68 , Issue.1 , pp. 149-156
    • Weiss, H.J.1    Sussman, I.I.2
  • 17
    • 0025146333 scopus 로고
    • 1-Desamino-8-D-arginine vasopressin (DDAVP) infusion in type IIB von Willebrand's disease: Shortening of bleeding time and induction of a variable pseudothrombocytopenia
    • Casonato A, Sartori MT, De Marco L, Girolami A. 1-Desamino-8-D-arginine vasopressin (DDAVP) infusion in type IIB von Willebrand's disease: shortening of bleeding time and induction of a variable pseudothrombocytopenia. Thromb Haemost. 1990;64(1):117-20.
    • (1990) Thromb Haemost , vol.64 , Issue.1 , pp. 117-120
    • Casonato, A.1    Sartori, M.T.2    de Marco, L.3    Girolami, A.4
  • 18
    • 0033065004 scopus 로고    scopus 로고
    • Post-DDAVP thrombocytopenia in type 2B von Willebrand disease is not associated with platelet consumption: Failure to demonstrate glycocalicin increase or platelet activation
    • Casonato A, Steffan A, Pontara E, Zucchetto A, Rossi C, De Marco L, et al. Post-DDAVP thrombocytopenia in type 2B von Willebrand disease is not associated with platelet consumption: failure to demonstrate glycocalicin increase or platelet activation. Thromb Haemost. 1999; 81(2):224-8.
    • (1999) Thromb Haemost , vol.81 , Issue.2 , pp. 224-228
    • Casonato, A.1    Steffan, A.2    Pontara, E.3    Zucchetto, A.4    Rossi, C.5    de Marco, L.6
  • 20
    • 0025060161 scopus 로고
    • Postoperative thrombocytopenia in type IIB von Willebrand disease
    • Hultin MB, Sussman II. Postoperative thrombocytopenia in type IIB von Willebrand disease. Am J Hematol. 1990; 33(1):64-8.
    • (1990) Am J Hematol , vol.33 , Issue.1 , pp. 64-68
    • Hultin, M.B.1    Sussman, I.I.2
  • 21
    • 37549033499 scopus 로고    scopus 로고
    • The effect of exercise on von Willebrand factor and ADAMTS-13 in individuals with type 1 and type 2B von Willebrand disease
    • Stakiw J, Bowman M, Hegadorn C, Pruss C, Notley C, Groot E, et al. The effect of exercise on von Willebrand factor and ADAMTS-13 in individuals with type 1 and type 2B von Willebrand disease. J Thromb Haemost. 2007;6(1):90-6.
    • (2007) J Thromb Haemost , vol.6 , Issue.1 , pp. 90-96
    • Stakiw, J.1    Bowman, M.2    Hegadorn, C.3    Pruss, C.4    Notley, C.5    Groot, E.6
  • 22
    • 0022445253 scopus 로고
    • Von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma
    • Holmberg L, Berntorp E, Donner M, Nilsson IM. Von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma. Blood. 1986; 68(3):668-72.
    • (1986) Blood , vol.68 , Issue.3 , pp. 668-672
    • Holmberg, L.1    Berntorp, E.2    Donner, M.3    Nilsson, I.M.4
  • 23
    • 36949030473 scopus 로고    scopus 로고
    • A novel von Willebrand factor mutation (I1372S) associated with type 2Blike von Willebrand disease: An elusive phenotype and a difficult diagnosis
    • Casonato A, Sartorello F, Pontara E, Gallinaro L, Bertomoro A, Grazia Cattini M, et al. A novel von Willebrand factor mutation (I1372S) associated with type 2Blike von Willebrand disease: an elusive phenotype and a difficult diagnosis. Thromb Haemost. 2007;98(6):1182-7.
    • (2007) Thromb Haemost , vol.98 , Issue.6 , pp. 1182-1187
    • Casonato, A.1    Sartorello, F.2    Pontara, E.3    Gallinaro, L.4    Bertomoro, A.5    Grazia, C.M.6
  • 24
    • 43549116884 scopus 로고    scopus 로고
    • A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor
    • Gallinaro L, Cattini MG, Sztukowska M, Padrini R, Sartorello F, Pontara E, et al. A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. Blood. 2008;111(7):3540-5.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3540-3545
    • Gallinaro, L.1    Cattini, M.G.2    Sztukowska, M.3    Padrini, R.4    Sartorello, F.5    Pontara, E.6
  • 25
    • 0036095699 scopus 로고    scopus 로고
    • Reduced von Willebrand factor survival in type Vicenza von Willebrand disease
    • Casonato A, Pontara E, Sartorello F, Cattini MG, Sartori MT, Padrini R, et al. Reduced von Willebrand factor survival in type Vicenza von Willebrand disease. Blood. 2002;99(1):180-4.
    • (2002) Blood , vol.99 , Issue.1 , pp. 180-184
    • Casonato, A.1    Pontara, E.2    Sartorello, F.3    Cattini, M.G.4    Sartori, M.T.5    Padrini, R.6
  • 26
    • 51249123703 scopus 로고    scopus 로고
    • Von Willebrand factor propeptide makes it easy to identify the shorter von Willebrand factor survival in patients with type 1 and type Vicenza von Willebrand disease
    • Sztukowska M, Gallinaro L, Cattini MG, Pontara, E, Sartorello F, Daidone V, et al. Von Willebrand factor propeptide makes it easy to identify the shorter von Willebrand factor survival in patients with type 1 and type Vicenza von Willebrand disease. Brit J Haematol. 2008;143(1):107-14.
    • (2008) Brit J Haematol , vol.143 , Issue.1 , pp. 107-114
    • Sztukowska, M.1    Gallinaro, L.2    Cattini, M.G.3    Pontara, E.4    Sartorello, F.5    Daidone, V.6
  • 27
    • 46749133213 scopus 로고    scopus 로고
    • Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: Molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD)
    • Haberichter SL, Castaman G, Budde U, Peake I, Goodeve A, Rodeghiero F, et al. Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). Blood. 2008;111(10): 4979-85.
    • (2008) Blood , vol.111 , Issue.10 , pp. 4979-4985
    • Haberichter, S.L.1    Castaman, G.2    Budde, U.3    Peake, I.4    Goodeve, A.5    Rodeghiero, F.6
  • 28
    • 0024431834 scopus 로고
    • A new congenital platelet abnormality characterized by spontaneous platelet aggregation, enhanced von Willebrand factor platelet interaction, and the presence of all von Willebrand factor multimers in plasma
    • Casonato A, De Marco L, Mazzuccato M, De Angelis V, De Roia D, Fabris F, et al. A new congenital platelet abnormality characterized by spontaneous platelet aggregation, enhanced von Willebrand factor platelet interaction, and the presence of all von Willebrand factor multimers in plasma. Blood. 1989;74(6):2028-33.
    • (1989) Blood , vol.74 , Issue.6 , pp. 2028-2033
    • Casonato, A.1    de Marco, L.2    Mazzuccato, M.3    de Angelis, V.4    de Roia, D.5    Fabris, F.6
  • 30
    • 9544220778 scopus 로고    scopus 로고
    • Pharmacokinetics of von Willebrand factor and factor VIIIC in patients with severe von Willebrand disease (type 3VWD): Estimation of the rate of factor VIIIC synthesis. Cooperative Study
    • Menache D, Aronson DL, Darr F, Montgomery RR, Gill JC, Kessler CM, et al. Pharmacokinetics of von Willebrand factor and factor VIIIC in patients with severe von Willebrand disease (type 3VWD): estimation of the rate of factor VIIIC synthesis. Cooperative Study. Br J Haematol. 1996; 94(4):740-5.
    • (1996) Br J Haematol , vol.94 , Issue.4 , pp. 740-745
    • Menache, D.1    Aronson, D.L.2    Darr, F.3    Montgomery, R.R.4    Gill, J.C.5    Kessler, C.M.6
  • 31
    • 0035001737 scopus 로고    scopus 로고
    • A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. On behalf of the ISTH SSC Subcommittee on von Willebrand factor
    • Goodeve AC, Eikenboom JCJ, Ginsburg D, Hilbert L, Mazurier C, Peake IR, et al. A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. On behalf of the ISTH SSC Subcommittee on von Willebrand factor. Thromb Haemost. 2001;85(5):929-31.
    • (2001) Thromb Haemost , vol.85 , Issue.5 , pp. 929-931
    • Goodeve, A.C.1    Eikenboom, J.C.J.2    Ginsburg, D.3    Hilbert, L.4    Mazurier, C.5    Peake, I.R.6
  • 32
    • 57149089069 scopus 로고    scopus 로고
    • Genetics of type 2B von Willebrand disease: True 2B, tricky 2B, or not 2B. What are the modifiers of the phenotype¿
    • Othman M, Favaloro EJ. Genetics of type 2B von Willebrand disease: true 2B, tricky 2B, or not 2B. What are the modifiers of the phenotype¿ Sem Thromb Hemost. 2008;34(6):520-31.
    • (2008) Sem Thromb Hemost , vol.34 , Issue.6 , pp. 520-531
    • Othman, M.1    Favaloro, E.J.2
  • 33
    • 1842530336 scopus 로고    scopus 로고
    • An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation
    • Lenting PJ, Westein E, Terraube V, Ribba AS, Huizinga EG, Meyer D, et al. An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation. J Biol Chem. 2004;279(13):12102-9.
    • (2004) J Biol Chem , vol.279 , Issue.13 , pp. 12102-12109
    • Lenting, P.J.1    Westein, E.2    Terraube, V.3    Ribba, A.S.4    Huizinga, E.G.5    Meyer, D.6
  • 34
    • 0022517442 scopus 로고
    • Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE)
    • Zimmerman TS, Dent JA, Ruggeri ZM, Nannini LH. Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE). J Clin Invest. 1986;77(3):947-51.
    • (1986) J Clin Invest , vol.77 , Issue.3 , pp. 947-951
    • Zimmerman, T.S.1    Dent, J.A.2    Ruggeri, Z.M.3    Nannini, L.H.4
  • 35
    • 60249092963 scopus 로고    scopus 로고
    • Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: A cohort sturdy of 67 patients
    • Federici AB, Mannucci PM, Castaman G, Baronciani L, Bucciarelli P, Canciani MT, et al. Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort sturdy of 67 patients. Blood. 2009;113(3):526-34.
    • (2009) Blood , vol.113 , Issue.3 , pp. 526-534
    • Federici, A.B.1    Mannucci, P.M.2    Castaman, G.3    Baronciani, L.4    Bucciarelli, P.5    Canciani, M.T.6
  • 36
    • 38349155217 scopus 로고    scopus 로고
    • Platelet-VWF complexes are preferred substrate of ADAMTS13 under fluid shear stress
    • Shim K, Anderson PJ, Tuley EA, Wiswall E, Sadler JE. Platelet-VWF complexes are preferred substrate of ADAMTS13 under fluid shear stress. Blood. 2008;111(2):651-7.
    • (2008) Blood , vol.111 , Issue.2 , pp. 651-657
    • Shim, K.1    Anderson, P.J.2    Tuley, E.A.3    Wiswall, E.4    Sadler, J.E.5
  • 37
    • 33846445722 scopus 로고    scopus 로고
    • Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand to ADAMTS-13
    • Rayes J, Hommais A, Legendre P, Tout H, Veyradier A, Obert B, et al. Effect of von Willebrand disease type 2B and type 2M mutations on the susceptibility of von Willebrand to ADAMTS-13. J Thromb Haemost. 2006;5(2):321-8.
    • (2006) J Thromb Haemost , vol.5 , Issue.2 , pp. 321-328
    • Rayes, J.1    Hommais, A.2    Legendre, P.3    Tout, H.4    Veyradier, A.5    Obert, B.6
  • 38
    • 0036893186 scopus 로고    scopus 로고
    • ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
    • Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002;100(12):4033-9.
    • (2002) Blood , vol.100 , Issue.12 , pp. 4033-4039
    • Dong, J.F.1    Moake, J.L.2    Nolasco, L.3    Bernardo, A.4    Arceneaux, W.5    Shrimpton, C.N.6
  • 39
    • 3242676770 scopus 로고    scopus 로고
    • Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13
    • Nishio K, Anderson PJ, Zheng XL, Sadler JE. Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. Proc Natl Acad Sci USA. 2004;101(29):10578-83.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.29 , pp. 10578-10583
    • Nishio, K.1    Anderson, P.J.2    Zheng, X.L.3    Sadler, J.E.4
  • 40
    • 48249131628 scopus 로고    scopus 로고
    • Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia
    • Wang ZJ, Onwuzurike N, Callaghan MU, Rajpurkar M, Chitlur M, Lusher JM. Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia. Pediatr Blood Cancer. 2008;51(3):416-8.
    • (2008) Pediatr Blood Cancer , vol.51 , Issue.3 , pp. 416-418
    • Wang, Z.J.1    Onwuzurike, N.2    Callaghan, M.U.3    Rajpurkar, M.4    Chitlur, M.5    Lusher, J.M.6


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