Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma

Biomarker Insights

Volumn 7, Issue , 2012, Pages 87-104

  Louten, Jennifer ^a,c   Mattson, Jeanine D ^a   Malinao, Maria Christina ^a   Li, Ying ^a   Emson, Claire ^a   Vega, Felix ^a   Wardle, Robert L ^b   Van Scott, Michael R ^b   Fick, Robert B ^a   Mcclanahan, Terrill K ^a   Malefyt, Rene de Waal ^a   Beaumont, Maribel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c SOUTHERN POLYTECHNIC STATE UNIVERSITY   (United States)

Author keywords

Asthma; Asthma treatment; Biomarkers; Corticosteroids; Murine; Nonhuman primate; Proximal fluid tissue

Indexed keywords

BIOLOGICAL MARKER; CAIDIC MAMMALIAN CHITINASE; CHITINASE 3 LIKE 4 PROTEIN; CHLORIDE CHANNEL REGULATOR 3 PROTEIN; CORTICOSTEROID; DEXAMETHASONE; EOSINOPHIL ASSOCIATED RIBONUCLEASE A FAMILY MEMBER 11 PROTEIN; EOSINOPHIL PEROXIDASE; GLYCOPROTEIN GP 39; INTELECTIN 2; INTERCELLULAR ADHESION MOLECULE 1; KALLIKREIN 1; LACTOFERRIN; MACROPHAGE ELASTASE; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN C; PROTEIN CLCA1; PROTEIN YM1; REGENERATING ISLET DERIVED 3 GAMMA PROTEIN; STEROID; THYMIC STROMAL LYMPHOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; GENE EXPRESSION REGULATION; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PREDICTIVE VALUE; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TREATMENT INDICATION; VALIDATION PROCESS;

ANIMALIA; MURINAE; MUS; PRIMATES; PYROGLYPHIDAE;

EID: 84864323443     PISSN: None     EISSN: 11772719     Source Type: Journal    
DOI: 10.4137/BMI.S9776     Document Type: Article

References (51)

1. Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183-92.
2. Kola I. The state of innovation in drug development. Clin Pharmacol Ther. 2008;83:227-30.
3. Zhou B, Comeau MR, De Smedt T, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005;6:1047-53.
4. Chan JR, Blumenschein W, Murphy E, et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006;203:2577-87.
5. Ayanoglu G, Desai B, Fick RB Jr. et al. Modeling asthma in macaques: longitudinal changes in cellular and molecular markers. Eur Respir J.
6. Zhao J, Yeong LH, Wong WS, Dexamethasone alters bronchoalveolar lavage fluid proteome in a mouse asthma model. Int Arch Allergy Immunol. 2007;142:219-29.
7. Van Scott MR, Hooker JL, Ehrmann D, et al. Dust mite-induced asthma in cynomolgus monkeys. J Appl Physiol. 2004;96:1433-44.
8. Zhao J, Zhu H, Wong CH, Leung KY, Wong WS. Increased lungkine and chitinase levels in allergic airway inflammation: a proteomics approach. Proteomics. 2005;5:2799-807.
9. Roh GS, Shin Y, Seo SW, et al. Proteome analysis of differential protein expression in allergen-induced asthmatic mice lung after dexamethasone treatment. Proteomics. 2004;4:3318-27.
10. Di Valentin E, Crahay C, Garbacki N, et al. New asthma biomarkers: lessons from murine models of acute and chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2009;296:L185-97.
11. Jeong H, Rhim T, Ahn MH, et al. Proteomic analysis of differently expressed proteins in a mouse model for allergic asthma. J Korean Med Sci. 2005;20:579-85.
12. Fajardo I, Svensson L, Bucht A, Pejler G. Increased levels of hypoxia-sensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med. 2004;170:477-84.
13. Zhang L, Wang M, Kang X, et al. Oxidative Stress and Asthma: Proteome Analysis of Chitinase-like Proteins and FIZZ1 in Lung Tissue and Bronchoalveolar Lavage Fluid. J Proteome Res. 2009.
14. Wong WS, Zhao J. Proteome analysis of chronically inflamed lungs in a mouse chronic asthma model. Int Arch Allergy Immunol. 2008;147: 179-89.
15. McMillan SJ, Lloyd CM. Prolonged allergen challenge in mice leads to persistent airway remodelling. Clin Exp Allergy. 2004;34:497-507.
16. Epstein MM. Do mouse models of allergic asthma mimic clinical disease? Int Arch Allergy Immunol. 2004;133:84-100.
17. Liu YJ, Soumelis V, Watanabe N, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol. 2007;25:193-219.
18. Lee CG, Hartl D, Lee GR, et al. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009.
19. Chupp GL, Lee CG, Jarjour N, et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med. 2007;357: 2016-27.
20. Shuhui L, Mok YK, Wong WS. Role of Mammalian Chitinases in Asthma. Int Arch Allergy Immunol. 2009;149:369-77.
21. Lanone S, Zheng T, Zhu Z, et al. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002;110:463-74.
22. Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev. 2007;87:69-98.
23. Harada N, Iijima S, Kobayashi K, et al. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. J Biol Chem. 1997;272:15232-41.
24. Long AJ, Sypek JP, Askew R, et al. Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am J Respir Cell Mol Biol. 2006;35:357-65.
25. Kim YM, Won TB, Kim SW, Min YG, Lee CH, Rhee CS. Histamine induces MUC5AC expression via a hCLCA1 pathway. Pharmacology. 2007;80:219-26.
26. Renigunta A, Hild C, Rose F, et al. Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia. FEBS Lett. 2006;580:900-3.
27. Mishra A, Wang M, Schlotman J, et al. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol. 2007;293:L305-13.
28. Clements JA, Willemsen NM, Myers SA, Dong Y. The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers. Crit Rev Clin Lab Sci. 2004;41:265-312.
29. Lauredo IT, Forteza RM, Botvinnikova Y, Abraham WM. Leukocytic cell sources of airway tissue kallikrein. Am J Physiol Lung Cell Mol Physiol. 2004;286:L734-40.
30. Phalipon A, Corthesy B. Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins. Trends Immunol. 2003;24:55-8.
31. Salvi S, Holgate ST. Could the airway epithelium play an important role in mucosal immunoglobulin A production? Clin Exp Allergy. 1999;29: 1597-605.
32. Cole AM, Waring AJ. The role of defensins in lung biology and therapy. Am J Respir Med. 2002;1:249-59.
33. Chan YR, Liu JS, Pociask DA, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 2009;182:4947-56.
34. Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG. MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med. 2007;204:1891-900.
35. Liu C, Gelius E, Liu G, Steiner H, Dziarski R. Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth. J Biol Chem. 2000;275:24490-9.
36. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol. 2006;24:147-74.
37. Blanchard C, Rothenberg ME. Biology of the eosinophil. Adv Immunol. 2009;101:81-121.
38. Novershtern N, Itzhaki Z, Manor O, Friedman N, Kaminski N. A functional and regulatory map of asthma. Am J Respir Cell Mol Biol. 2008;38:324-36.
39. Elias JA, Homer RJ, Hamid Q, Lee CG. Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. J Allergy Clin Immunol. 2005;116:497-500.
40. Hartl D, He CH, Koller B, et al. Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. J Biol Chem. 2008;283:33472-82.
41. Heath H, Qin S, Rao P, et al. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest. 1997;99:178-84.
42. Bochner BS, Bickel CA, Taylor ML, et al. Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3-and CC chemokine receptor 4-independent manner. J Allergy Clin Immunol. 1999;103:527-32.
43. Lee JH, Chang HS, Kim JH, et al. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. J Allergy Clin Immunol. 2007;120:1110-7.
44. De Lucca GV. Recent developments in CCR3 antagonists. Curr Opin Drug Discov Devel. 2006;9:516-24.
45. Pease JE. Asthma, allergy and chemokines. Curr Drug Targets. 2006; 7:3-12.
46. Schuh JM, Blease K, Kunkel SL, Hogaboam CM. Chemokines and cytokines: axis and allies in asthma and allergy. Cytokine Growth Factor Rev. 2003;14:503-10.
47. Bisset LR, Schmid-Grendelmeier P. Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Curr Opin Pulm Med. 2005;11:35-42.
48. Garcia G, Godot V, Humbert M. New chemokine targets for asthma therapy. Curr Allergy Asthma Rep. 2005;5:155-60.
49. Heijink IH, Van Oosterhout AJ. Targeting T cells for asthma. Curr Opin Pharmacol. 2005;5:227-31.
50. Chantry D, Burgess LE. Chemokines in allergy. Curr Drug Targets Inflamm Allergy. 2002;1:109-6.
51. Weber M, Uguccioni M, Ochensberger B, Baggiolini M, Clark-Lewis I, Dahinden CA. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. J Immunol. 1995;154:4166-72.