The role of Ras-ERK-IL-1β signaling pathway in upregulation of elastin expression by human coronary artery smooth muscle cells cultured in 3D scaffolds

Biomaterials

Volumn 33, Issue 29, 2012, Pages 7047-7056

  Lin, Shigang ^a   Mequanint, Kibret ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

3D signaling pathways; Elastin; Phosphorylation; Tissue engineering; Vascular smooth muscle cells; Western blot

Indexed keywords

3D CULTURE; 3D SCAFFOLDS; ADHESION PROTEINS; CELL FUNCTIONS; CELL SIGNALING; CELL SURFACE RECEPTORS; DOWN-REGULATION; ELASTIC RECOIL; ELASTIN; EXTRACELLULAR MATRICES; FOCAL ADHESION KINASE; GENE TRANSCRIPTIONS; HUMAN CORONARY ARTERIES; IN-VIVO; INTEGRINS; INTERLEUKIN-1; MOLECULAR MECHANISM; PAXILLIN; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING PATHWAYS; STRUCTURAL COMPONENT; SYNTHETIC SCAFFOLDS; THREE-DIMENSIONAL (3D) SCAFFOLDS; TRANSIENT TRANSFECTION; UP-REGULATION; VASCULAR SMOOTH MUSCLE CELLS; VASCULAR TISSUE; VINCULIN; WESTERN BLOTS;

ADHESION; AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; ENZYME INHIBITION; GENES; GLYCOPROTEINS; PHOSPHORYLATION; PIGMENTS; SIGNAL TRANSDUCTION; SIGNALING; THREE DIMENSIONAL; TISSUE; TISSUE ENGINEERING; TRANSCRIPTION; TWO DIMENSIONAL;

SCAFFOLDS (BIOLOGY);

ELASTIN; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 2; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PAXILLIN; PROTEIN CDC42; RAF PROTEIN; RAS PROTEIN; SMALL INTERFERING RNA; TISSUE SCAFFOLD; VERY LATE ACTIVATION ANTIGEN 5; VINCULIN;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSIENT TRANSFECTION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

CELL ADHESION; CELL CULTURE TECHNIQUES; CORONARY VESSELS; ELASTIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; MUSCLE, SMOOTH, VASCULAR; RAS PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE SCAFFOLDS; UP-REGULATION;

EID: 84864322504     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.044     Document Type: Article

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