T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes

Immunobiology

Volumn 217, Issue 9, 2012, Pages 920-925

  Fozza, Claudio ^a   Contini, Salvatore ^a   Corda, Giovanna ^a   Virdis, Patrizia ^a   Galleu, Antonio ^a   Bonfigli, Silvana ^a   Pacifico, Adolfo ^a   Maioli, Mario ^a   Mastinu, Francesco ^b   Pitzalis, Maristella ^a   Cucca, Francesco ^a   Longinotti, Maurizio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b San Martino Hospital   (Italy)

Author keywords

Flow cytometry; Monozygotic twins; Spectratyping; T cell receptor repertoire; Type 1 diabetes

Indexed keywords

T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; ANALYTIC METHOD; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CRD3 SPECTRATYPING; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; HEREDITY; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; TWIN CONCORDANCE; TWIN DISCONCORDANT; TWINS;

ADOLESCENT; ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 84864319297     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.01.002     Document Type: Article

References (28)

1. Boomsma D., Busjahn A., Peltonen L. Classical twin studies and beyond. Nat. Rev. Genet. 2002, 3:872.
2. Chen X., Barfield R., Benaim E., Leung W., Knowles J., Lawrence D., Otto M., Shurtleff S.A., Neale G.A., Behm F.G., Turner V., Handgretinger R. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 2005, 105:886.
3. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162:156.
4. Davey M.P., Meyer M.M., Bakke A.C. T cell receptor V beta gene expression in monozygotic twins. Discordance in CD8 subset and in disease states. J. Immunol. 1994, 152:315.
5. Dokai H., Nomura Y., Fujikawa Y., Nihei K., Segawa M., Shinomiya N. A study of the factors inducing the development of childhood-onset myasthenia gravis using CDR3 spectratyping analysis of the TCR repertoire. J. Neuroimmunol. 2007, 187:192.
6. Fozza C., Nadal E., Longinotti M., Dazzi F. T-cell receptor repertoire usage after allografting differs between CD4+ CD25+ regulatory T cells and their CD4+ CD25-counterpart. Haematologica 2007, 92:206.
7. Gorski J., Yassai M., Zhu X., Kissela B., Kissella B., Keever C., Flomenberg N. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J. Immunol. 1994, 152:5109.
8. Gulwani-Akolkar B., Shalon L., Akolkar P.N., Fisher S.E., Silver J. Analysis of the peripheral blood T-cell receptor (TCR) repertoire in monozygotic twins discordant for Crohn's disease. Autoimmunity 1994, 17:241.
9. Haegert D.G., Galutira D., Murray T.J., O'Connor P., Gadag V. Identical twins discordant for multiple sclerosis have a shift in their T-cell receptor repertoires. Clin. Exp. Immunol. 2003, 134:532.
10. Hawes G.E., Struyk L., van den Elsen P.J. Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins. J. Immunol. 1993, 150:2033.
11. Holtmeier W., Rowell D.L., Nyberg A., Kagnoff M.F. Distinct delta T cell receptor repertoires in monozygotic twins concordant for coeliac disease. Clin. Exp. Immunol. 1997, 107:148.
12. Junker A., Ivanidze J., Malotka J., Eiglmeier I., Lassmann H., Wekerle H., Meinl E., Hohlfeld R., Dornmair K. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 2007, 130:2789.
13. Kuwana M., Feghali C.A., Medsger T.A., Wright T.M. Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis. Arthritis Rheum. 2001, 44:1654.
14. Lu J., Basu A., Melenhorst J.J., Young N.S., Brown K.E. Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood 2004, 103:4588.
15. Miles J.J., Douek D.C., Price D.A. Bias in the alphabeta T-cell repertoire: implications for disease pathogenesis and vaccination. Immunol. Cell Biol. 2011, 89:375.
16. Monteiro J., Hingorani R., Choi I.H., Silver J., Pergolizzi R., Gregersen P.K. Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases. Mol. Med. 1995, 1:614.
17. Muraro P.A., Cassiani-Ingoni R., Chung K., Packer A.N., Sospedra M., Martin R. Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis. J. Neuroimmunol. 2006, 171:177.
18. Nanki T., Kohsaka H., Mizushima N., Ollier W.E., Carson D.A., Miyasaka N. Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. J. Clin. Invest. 1996, 98:1594.
19. Nikolich-Zugich J., Slifka M.K., Messaoudi I. The many important facets of T-cell repertoire diversity. Nat. Rev. Immunol. 2004, 4:123.
20. Quinn A., McInerney M., Huffman D., McInerney B., Mayo S., Haskins K., Sercarz E. T cells to a dominant epitope of GAD65 express a public CDR3 motif. Int. Immunol. 2006, 18:967.
21. Reisaeter A.V., Thorsby E., Brinchmann J.E. Allospecific helper T-lymphocyte repertoire in monozygotic twins. Scand. J. Immunol. 1998, 47:381.
22. Somma P., Ristori G., Battistini L., Cannoni S., Borsellino G., Diamantini A., Salvetti M., Sorrentino R., Fiorillo M.T. Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis. J. Leukoc. Biol. 2007, 81:696.
23. Todd J.A. Etiology of type 1 diabetes. Immunity 2010, 32:457.
24. Trevino M.A., Teixeiro E., Bragado R. CD8+ T cells oligoclonally expanded in synovial fluid at onset of spondyloarthropathy selectively proliferate in response to self-antigens: characterization of cell specificities in nonclonal populations. J. Rheumatol. 2004, 31:1962.
25. Utz U., Biddison W.E., McFarland H.F., McFarlin D.E., Flerlage M., Martin R. Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature 1993, 364:243.
26. van den Beemd R., Boor P.P., van Lochem E.G., Hop W.C., Langerak A.W., Wolvers-Tettero I.L., Hooijkaas H., van Dongen J.J. Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 2000, 40:336.
27. Walters G., Habib A.M., Reynolds J., Wu H., Knight J.F., Pusey C.D. Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis. Nephron Exp. Nephrol. 2004, 98:e71.
28. Wong C.P., Stevens R., Long B., Li L., Wang Y., Wallet M.A., Goudy K.S., Frelinger J.A., Tisch R. Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J. Immunol. 2007, 178:1388.