Distinct δ T cell receptor repertoires in monozygotic twins concordant for coeliac disease

Clinical and Experimental Immunology

Volumn 107, Issue 1, 1997, Pages 148-157

  Holtmeier, W ^a,b   Rowell, D L ^a   Nyberg, A ^a   Kagnoff, M F ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Coeliac disease; Monozygotic twins; T cell receptor repertoire; T cells; T cell receptor

Indexed keywords

CD3 ANTIGEN; HLA DQ ANTIGEN; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CASE REPORT; CELIAC DISEASE; HLA SYSTEM; HUMAN; MALE; MONOZYGOTIC TWINS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031032261     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-887.x     Document Type: Article

References (56)

1. Shewry PR. Tatham AS, Kasarda D. Cereal proteins and coeliac disease. In: Marsh MN, ed. Coeliac disease. Oxford: Blackwell Scientific Publications, 1992:305-48.
2. Kagnoff MF. Celiac disease. In: Yamada T, Alpers DH. Owyang C, Powell DW, Silverstein F, eds. Textbook of gastroenterology, 2nd edn. Philadelphia: J. B. Lippincott Co., 1995:1643-61.
3. Polanco I, Biemond I, Leeuwen A. Gluten sensitive enteropathy in Spain: genetic and environmental factors, In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press, 1981:211-30.
4. Sollid L, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer. J Exp Med 1989; 169:345-50.
5. Kagnoff MF, Harwood J, Bugawan TL, Erlich HA. Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype. Proc Natl Acad Sci USA 1989; 86:6274-8.
6. Kagnoff MF. Understanding the molecular basis of coeliac disease. Gut 1990; 31:497-9.
7. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105:910-22.
8. Lundin KE, Gjertsen HA, Scott H, Sollid LM, Thorsby E. Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease. Human Immunol 1994; 41:24-27.
9. Mearin ML, Biemond I. Pena AS, Polanco I, Vazquez C, Schreuder GT, de Vries RR, van Rood JJ. HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease. Gut 1983; 24:532-7.
10. Spencer J. Isaacson PG, Diss TC, MacDonald TT. Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 1989; 19:1335-8.
11. + phenotypes are increased in coeliac disease. Scand J Immunol 1989; 30:665-72.
12. Spencer J, Isaacson PG, MacDonald TT, Thomas AJ, Walker-Smith JA. γ/δ T cells and the diagnosis of coeliac disease. Clin Exp Immunol 1991; 85:109-13.
13. Ullrich R, Schieferdecker HL, Ziegler K, Riecken EO, Zeitz M. γ/δ T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cell Immunol 1990; 128:619-27.
14. Deusch K, Luling F, Reich K, Classen M, Wagner H, Pfeffer K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the VδI gene segment. Eur J Immunol 1991; 21:1053-9.
15. Savilahti E, Arato A, Verkasalo M. Intestinal γ/δ receptor-bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease. Pediatr Res 1990; 28:579-81.
16. + intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut 1993; 34:208-14.
17. Maki M, Holm K, Collin P, Savilahti E. Increase in γ/β T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 1991; 32:1412-4.
18. Arranz E, Bode J, Kingstone K, Ferguson A. Intestinal antibody pattern of coeliac disease: association with γ/δ T tell receptor expression by intraepithelial lymphocytes, and other indices of potential coeliac disease. Gut 1994; 35:476-82.
19. Arranz E, Ferguson A. Jejunal fluid antibodies and mucosal γ/δ IEL in latent and potential coeliac disease. Adv Exp Med Biol 1995; 371B:1345-8.
20. Holm K, Maki M, Savilahti E, Lipsanen V, Laippala P, Koskimies S. Intraepithelial γ/δ T-cell-receptor lymphocytes and genetic susceptibility to coeliac disease. Lancet 1992; 339:1500-3.
21. Trejdosiewicz LK, Calabrese A, Smart CJ et al. γ/δ T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Helicobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease. Clin Exp Immunol 1991; 84:440-4.
22. Davis MM, Bjorkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334:395-402.
23. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. WHO-IUIS Nomenclature Sub-Committee on TCR Designation. Bull WHO 1993; 71:113-5.
24. Holtmeier W, Chowers Y, Lumeng A, Morzycka-Wroblewska E. Kagnoff MF. The δ T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J Clin Invest 1995; 96:1108-17.
25. De Libero G, Rocci MP, Casorati G, Giachino C, Oderda G, Tavassoli K, Migone N. T cell receptor heterogeneity in γ/δ T cell clones from intestinal biopsies of patients with celiac disease. Eur J Immunol 1993; 23:499-504.
26. Peyrat M-A, Davodeau F, Houde I et al. Repertoire analysis of human peripheral blood lymphocytes using a human Vδ3 regionspecific monoclonal antibody. J Immunol 1995; 155:3060-7.
27. Borst J, Wicherink A, Van Dongen JJM, De Vries E, Comans-Bitter WM, Wassenaar F, Van Den Elsen P. Non-random expression of T cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood. Eur J Immunol 1989; 19:1559-68.
28. + clones from thymus and peripheral blood. J Exp Med 1989; 170:1521-35.
29. + T cells in coeliac disease. Scand J Immunol 1992; 35:459-68.
30. Alford RL, Hammond HA, Coto I, Caskey CT. Rapid and efficient resolution of parentage by amplification of short tandem repeats. Am J Hum Genet 1994; 55:190-5.
31. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2h: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39:225-35.
32. Salazar M, Deulofeut R, Yunis JJ, Bing DH, Yunis EJ. A fast PCR-SSP method for HLA-DQ generic typing. Tissue Antigens 1993; 41:102-6.
33. Chowers Y, Holtmeier W, Harwood J, Morzycka-Wroblewska E. Kagnoff MF. The VδM T cell receptor repertoire in human small intestine and colon. J Exp Med 1944; 180:183-90.
34. Magazzu G, Bottari M, Tuccari G, Arco A, Pallio S, Lucanlo C, Tortora A, Barresi G. Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults. J Clin Gastroenterol 1994; 19:255-7.
35. Loh EY, Cwirla S, Serafini AT. Phillips JH, Lanier LL. Human T-cell-receptor δ chain: genomic organization, diversity, and expression in populations of cells. Proc Natl Acad Sci USA 1988; 85:9714-8.
36. Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reimann J, Minden M, Mak TW. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell δ-chain locus. Proc Natl Acad Sci USA 1988; 85:6097-101.
37. Satyanarayana K, Hata S, Devlin P, Roncarolo MG, De Vries JE, Spits H, Strominger JL. Krangel MS. Genomic organization of the human T-cell antigen-receptor α/δ locus. Proc Natl Acad Sci USA 1988; 85:8166-70.
38. Dariavach P, Lefranc M-P. First genomic sequence of the human T-cell receptor δ2 gene (TRDV2). Nucl Acids Res 1989; 17:4880.
39. Hata S, Clabby M, Devlin P, Spits H, De Vries JE, Krangel MS. Diversity and organization of human T cell receptor δ variable gene segments. J Exp Med 1989; 169:41-57.
40. Arden B, Clark SP, Kabelitz D, Mak TW. Human T-cell receptor variable gene segment families. Immunogenetics 1995; 42:455-500.
41. Rock EP, Sibbald PR, Davis MM, Chien Y-H. CDR3 length in antigen-specific immune receptors. J Exp Med 1994; 179:323-8.
42. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest. In: National Institutes of Health Publication no. 91-3242, 5th edn. Bethesda: 1991.
43. IUPAC-IUB Commission on Biochemical Nomenclature. A one-letter notation for amino acíd sequences. Tentative rules. Biochem J 1969; 113:1.
44. + cells with restricted T cell receptor δ gene junctional repertoire in the peripheral blood of healthy donors. J Exp Med 1993; 178:121-7.
45. + cells increase with age and limit the repertoire of human γ/δ T cells. Eur J Immunol 1994; 24:1914-8.
46. Ensari A, Marsh MN, Loft DE, Morgan S, Moriarty K. Morphometric analysis of intestinal mucosa. V Quantitative histological and immunocytochemical studies of rectal mucosae in gluten sensitivity. Gut 1993; 34:1225-9.
47. Breen EG, Coughlan G, Connolly CE, Stevens FM, McCarthy CF. Coeliac proctitis. Scand J Gastroenterol 1987; 22:471-7.
48. DuBois RN, Lazenby AJ, Yardley JH, Hendrix TR, Bayless TM, Giardiello EM. Lymphocytic enterocolitis in patients with 'refractory sprue'. JAMA 1989; 262:935-7.
49. Loft DE, Marsh MN, Sandle GI, Crowe PT, Garner V, Gordon D, Baker R. Studies of intestinal lymphoid tissue. XII. Epithelial lymphocyte and mucosal responses to rectal gluten challenge in celiac sprue. Gastroenterology 1989; 97:29-37.
50. Ensari A, Ager A, Marsh MN, Morgan S, Moriarty KJ. Time-course of adhesion molecule expression in rectal mucosa of gluten-sensitive subjects after gluten challenge. Clin Exp Immunol 1993; 92:303-7.
51. Schild H, Mavaddat N, Litzenberger C, Bluestone JA, Malis L, Draper RK, Chien Y-H. The nature of major histocompatibility complex recognition by γ/δ T cells. Cell 1994; 76:29-37.
52. Weintraub BC, Jackson MR, Hedrick SM. γ/δ T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J Immunol 1994; 153:3051-8.
53. Tanaka Y, Morita CT, Nieves E, Brenner MB, Bloom BR. Natural and synthetic non-peptide antigens recognized by human γ δ T cells. Nature 1995;375:155-8.
54. Tanaka Y, Sano S, Nieves E et al. Nonpeptide ligands for human γ/δ T cells. Proc Natl Acad Sci USA 1994; 91:8175-9.
55. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H. Bloom BR, Golan DE, Brenner MB. Direct presentation of non-peptide prenyl pyrophosphate antigens to human γ/δ T cells. Immunity 1995;3:495-507.
56. Clark JM. Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases. Nucl Acids Res 1988; 16:9677-87.