Poly(ethylene glycol) cross-linked hemoglobin with antioxidant enzymes protects pancreatic islets from hypoxic and free radical stress and extends islet functionality

Biotechnology and Bioengineering

Volumn 109, Issue 9, 2012, Pages 2392-2401

  Nadithe, Venkatareddy ^a   Mishra, Deepa ^b   Bae, You Han ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c Utah Inha DDS and Advanced Theapeutics Research Center   (South Korea)

Author keywords

Antioxidants; Hypoxia; Islets; Oxygen carrier; Poly(ethylene glycol) cross linking; Tissue engineering

Indexed keywords

3-(4 ,5-DIMETHYLTHIAZOL-2-YL)-2 ,5-DIPHENYL TETRAZOLIUM BROMIDE; ANTIOXIDANT ENZYME; ANTIOXIDANTS; BETA CELL; CELL PROTECTION; CELL VIABILITY; CROSSLINKED; FREE-RADICAL ACTIVITY; HYPOXIA; INDUCED STRESS; INSULIN SECRETION; ISLETS; OXYGEN CARRIER; PANCREATIC ISLET; SUPEROXIDES; XANTHINE OXIDASE;

BROMINE COMPOUNDS; CELLS; CYTOLOGY; ENZYMES; FREE RADICALS; INSULIN; OXYGEN; POLYETHYLENE GLYCOLS; TISSUE ENGINEERING;

HEMOGLOBIN;

MACROGOL; MACROGOL CONJUGATED SUPEROXIDE ISMUTASE CATALASE HEMOGLOBIN; METHEMOGLOBIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DRUG CONJUGATION; DRUG EFFECT; HYPOXIA; INSULIN RELEASE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; RAT;

ANIMALS; ANTIOXIDANTS; CATTLE; CELL HYPOXIA; CELL SURVIVAL; ERYTHROCYTES; FREE RADICALS; HEMOGLOBINS; HYDROGEN PEROXIDE; INSULIN; ISLETS OF LANGERHANS; MALE; METHEMOGLOBIN; MICROSCOPY, CONFOCAL; OXIDATIVE STRESS; OXIDOREDUCTASES; OXYGEN; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING;

EID: 84864307480     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24501     Document Type: Article

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