Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4

Immunobiology

Volumn 217, Issue 9, 2012, Pages 864-872

  Toda, Teppei ^a   Kuwahara, Kazuhiko ^a   Kondo, Naoyuki ^b,c   Matsuda, Zene ^b   Maeda, Yosuke ^a   Maeda, Kazuhiko ^a   Sakaguchi, Nobuo ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b INSTITUTE OF BIOPHYSICS   (China)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD4; High affinity antibody; HIV 1; Viral membrane fusion; Virus neutralization

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; EPITOPE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; MONOCLONAL ANTIBODY; OKT 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ARTICLE; COCULTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GANP GENE; GENE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; MEMBRANE FUSION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSGENIC MOUSE; VIRAL FUSION COMPLEX; VIRUS NEUTRALIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CELL LINE; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES, T-LYMPHOCYTE; GENE ORDER; GENE TARGETING; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; MICE; MICE, TRANSGENIC; NEUTRALIZATION TESTS; PROTEIN BINDING; RECEPTORS, CXCR4; VIRUS INTERNALIZATION;

EID: 84864306705     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.12.007     Document Type: Article

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