The alpha-1-antitrypsin gene promoter in human A549 lung derived cells, and a novel transcription initiation site

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 5, 2009, Pages 1157-1164

  Morgan, Kevin ^a   Chappell, Sally ^a   Guetta Baranés, Tamar ^a   Morley, Stephen ^a   Kalsheker, Noor ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Cytokine; Gene regulation; Lung; Promoter; SerpinA1

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYTOKINE; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR SP1;

ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INFLAMMATION; LIVER; LUNG ALVEOLUS CELL; LUNG INJURY; PROMOTER REGION; PROTEIN DEGRADATION; RNA ISOLATION; SITE DIRECTED MUTAGENESIS; TATA BOX; TRANSCRIPTION INITIATION SITE;

ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CELLS, CULTURED; ENHANCER ELEMENTS, GENETIC; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PULMONARY ALVEOLI; SP1 TRANSCRIPTION FACTOR; TATA BOX; TRANSCRIPTION INITIATION SITE; U937 CELLS;

EID: 59649130240     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.10.020     Document Type: Article

References (15)

1. Boutten A., Venembre P., Seta N., Hamelin J., Aubier M., Durand G., et al. Oncostatin M is a potent stimulator of alpha(1)-antitrypsin secretion in lung epithelial cells: modulation by transforming growth factor-beta and interferon-gamma. Am J Respir Cell Mol Biol 18 (1998) 511-520
2. Chiang C.M., and Roeder R.G. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. Science 267 (1995) 531-536
3. Cichy C., Potempa J., and Travis J. Biosynthesis of alpha(1)-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem 272 (1997) 8250-8255
4. Crystal R.G. Alpha-1-antitrypsin deficiency, emphysema, and liver-disease - genetic-basis and strategies for therapy. J Clin Invest 85 (1990) 1343-1352
5. Hafeez W., Ciliberto G., and Perlmutter D.H. Constitutive and modulated expression of the human alpha-1-antitrypsin gene - different transcriptional initiation sites used in 3 different cell-types. J Clin Invest 89 (1992) 1214-1222
6. 1-proteinase inhibitor gene. J Biol Chem 273 (1998) 9959-9965
7. Long G.L., Chandra T., Woo S.L.C., Davies E.W., and Kurachi K. Complete sequence of the cdna for human alpha-1-antitrypsin and the gene for the S-variant. Biochemistry 23 (1984) 4828-4837
8. Majello B., De Luca P., and Lania L. Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 272 7 (1997) 4021-4026
9. Maruyama Y., Li Y., Zhang Y., Wang X., Sugar J., and Yue B.Y.J.T. Mapping of Sp1 regulation sites in the promoter of the human alpha 1-proteinase inhibitor gene. J Cell Biochem 85 (2002) 482-489
10. Morgan K., Licastro F., Tilley L., Ritchie A., Morgan L., Pedrini S., et al. Polymorphism in the alpha1-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations. Hum Genet 109 (2001) 303-310
11. Mornex J.F., Chytil-Wier A., Martinet Y., Courtney M., LeCocq J.P., and Crystal R.G. Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals. J Clin Invest 77 (1986) 1952-1961
12. Perlino E., Cortese R., and Ciliberto G. The human alpha-1-antitrypsin gene is transcribed from 2 different promoters in macrophages and hepatocytes. EMBO J 6 (1987) 2767-2771
13. Ritchie A., Morgan K., and Kalsheker N. Allele-specific overexpression in astrocytes of an Alzheimer's disease associated alpha-1-antichymotrypsin promoter polymorphism. Mol Brain Res 131 (2004) 88-92
14. Sallenave J.M., Tremblay G.M., Gauldie J., and Richards C.D. Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha(1)-proteinase inhibitor in A549 human alveolar epithelial cells. J Interferon Cytokine Res 17 (1997) 337-346
15. Tower C., Chappell S., Morgan K., Kalsheker N., Baker P., and Morgan L. Transforming growth factor β1 regulates angiotensin II type I receptor (AT1) gene expression in the extravillous trophoblast cell line SGH-PL4. Hum Mol Reprod 11 (2005) 847-852