Arterial microcalcification in atherosclerotic patients with and without chronic kidney disease: A comparative high-resolution scanning X-ray diffraction analysis

Calcified Tissue International

Volumn 90, Issue 6, 2012, Pages 465-472

  Fischer, Dagmar Christiane ^a,b   Behets, Geert J ^c   Hakenberg, Oliver W ^d   Voigt, Mathias ^a   Vervaet, Benjamin A ^c   Robijn, Stef ^c   Kundt, Günther ^d   Schareck, Wolfgang ^d   D'Haese, Patrick C ^c   Haffner, Dieter ^a,b  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Apatite; Arterial microcalcification; Chronic kidney disease; Whitlockite; X ray diffraction; X ray fluorescence

Indexed keywords

APATITE; CALCIUM PHOSPHATE;

ADULT; AGED; ARTERIAL MICROCALCIFICATION; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; CHEMICAL COMPOSITION; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; KIDNEY FUNCTION; PRIORITY JOURNAL; X RAY DIFFRACTION;

AGED; AGED, 80 AND OVER; CALCIUM PHOSPHATES; CAROTID ARTERIES; CAROTID ARTERY DISEASES; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; SPECTROMETRY, X-RAY EMISSION; VASCULAR CALCIFICATION; X-RAY DIFFRACTION;

EID: 84864290621     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9594-5     Document Type: Article

References (33)

1. Rennenberg RJ, Kessels AG, Schurgers LJ, van Engelshoven JM, de Leeuw PW, Kroon AA (2009) Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vasc Health Risk Manag 5:185-197
2. Persy V, D'Haese P (2009) Vascular calcification and bone disease: the calcification paradox. Trends Mol Med 15:405-416
3. Atkinson J (2008) Age-related medial elastocalcinosis in arteries: mechanisms, animal models, and physiological consequences. J Appl Physiol 105:1643-1651
4. Abedin M, Tintut Y, Demer LL (2004) Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol 24:1161-1170 (Pubitemid 38880003)
5. Dellegrottaglie S, Sanz J, Rajagopalan S (2006) Molecular determinants of vascular calcification: a bench to bedside view. Curr Mol Med 6:515-524
6. O'Neill WC, Lomashvili KA (2010) Recent progress in the treatment of vascular calcification. Kidney Int 78:1232-1239
7. Demer LL, Tintut Y (2008) Vascular calcification: pathobiology of a multifaceted disease. Circulation 117:2938-2948 (Pubitemid 351787058)
8. Speer MY, Giachelli CM (2004) Regulation of cardiovascular calcification. Cardiovasc Pathol 13:63-70 (Pubitemid 38366423)
9. Shao JS, Cai J, Towler DA (2006) Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol 26:1423-1430 (Pubitemid 44288965)
10. Shao JS, Cheng SL, Sadhu J, Towler DA (2010) Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 55:579-592
11. Voigt M, Fischer DC, Rimpau M, Schareck W, Haffner D (2010) Fibroblast growth factor (FGF)-23 and fetuin-A in calcified carotid atheroma. Histopathology 56:775-788
12. Bobryshev YV (2005) Transdifferentiation of smooth muscle cells into chondrocytes in atherosclerotic arteries in situ: implications for diffuse intimal calcification. J Pathol 205:641-650 (Pubitemid 40514838)
13. Neven E, Dauwe S, De Broe ME, D'Haese PC, Persy V (2007) Endochondral bone formation is involved in media calcification in rats and in men. Kidney Int 72:574-581 (Pubitemid 47312790)
14. Jahnen-Dechent W, Heiss A, Schäfer C, Ketteler M (2011) Fetuin- a regulation of calcified matrix metabolism. Circ Res 108:1494-1509
15. Vattikuti R, Towler DA (2004) Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab 286:E686-E696 (Pubitemid 38506938)
16. Toussaint ND (2011) Extracellular matrix calcification in chronic kidney disease. Curr Opin Nephrol Hypertens 20:360-368
17. Wuthier RE, Lipscomb GF (2011) Matrix vesicles: structure, composition, formation and function in calcification. Front Biosci 17:2812-2902
18. Verberckmoes SC, Persy V, Behets GJ, Neven E, Hufkens A, Zebger-Gong H, Muller D, Haffner D, Querfeld U, Bohic S, De Broe ME, D'Haese PC (2007) Uremia-related vascular calcification: more than apatite deposition. Kidney Int 71:298-303 (Pubitemid 46227088)
19. LeGeros RZ, Contiguglia SR, Alfrey AC (1973) Pathological calcifications associated with uremia: two types of calcium phosphate deposits. Calcif Tissue Res 13:173-185
20. Lagier R, Baud CA (2003) Magnesium whitlockite, a calcium phosphate crystal of special interest in pathology. Pathol Res Pract 199:329-335 (Pubitemid 36939584)
21. Schlieper G, Aretz A, Verberckmoes SC, Krüger T, Behets GJ, Ghadimi R, Weirich TE, Rohrmann D, Langer S, Tordoir JH, Amann K, Westenfeld R, Brandenburg VM, D'Haese PC, Mayer J, Ketteler M, McKee MD, Floege J (2010) Ultrastructural analysis of vascular calcifications in uremia. J Am Soc Nephrol 21:689-696
22. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in Renal Disease Study Group. Ann Intern Med 130:461-470 (Pubitemid 29135798)
23. Haffner D, Hocher B, Muller D, Simon K, Konig K, Richter CM, Eggert B, Schwarz J, Godes M, Nissel R, Querfeld U (2005) Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3. J Hypertens 23:1067-1075 (Pubitemid 40637927)
24. Hammersley AP, Svensson SO, Hanfland M, Fitch AN, Hausermann D (1996) Two-dimensional detector software: from real detector to idealised image or two-theta scan. High Press Res 14:235
25. Murshed M, McKee MD (2010) Molecular determinants of extracellular matrix mineralization in bone and blood vessels. Curr Opin Nephrol Hypertens 19:359-365
26. Reid JD, Andersen ME (1993) Medial calcification (whitlockite) in the aorta. Atherosclerosis 101:213-224 (Pubitemid 23214234)
27. O'Neill WC (2007) Vascular calcification: not so crystal clear. Kidney Int 71:282-283 (Pubitemid 46227084)
28. Zittermann A, Schleithoff SS, Koerfer R (2007) Vitamin D and vascular calcification. Curr Opin Lipidol 18:41-46 (Pubitemid 46090236)
29. Shroff R, Knott C, Rees L (2010) The virtues of vitamin D-but how much is too much? Pediatr Nephrol 25:1607-1620
30. Razzaque MS (2011) The dualistic role of vitamin D in vascular calcifications. Kidney Int 79:708-714
31. de Boer IH, Kestenbaum B, Shoben AB, Michos ED, Sarnak MJ, Siscovick DS (2009) 25-Hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. J Am Soc Nephrol 20:1805-1812
32. Lopez I, Mendoza FJ, Aguilera-Tejero E, Perez J, Guerrero F, Martin D, Rodriguez M (2008) The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats. Kidney Int 73:300-307
33. Arsenault AL, Ottensmeyer FP, Heath IB (1988) An electron microscopic and spectroscopic study of murine epiphyseal cartilage: analysis of fine structure and matrix vesicles preserved by slam freezing and freeze substitution. J Ultrastruct Mol Struct Res 98:32-47