Association between the COMT Val158Met polymorphism and breast cancer risk: A meta-analysis of 30,199 cases and 38,922 controls

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6811-6823

  He, Xiao Feng ^a   Wei, Wu ^b   Li, Shao Xia ^a   Su, Jiao ^a   Zhang, Ying ^c   Ye, Xiang Hua ^d   Liu, Yi ^e   Wang, Wei ^f  

^a CHANGZHI MEDICAL COLLEGE   (China)

^b Medical College   (China)

^c JINAN UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY   (China)

^e SOUTHERN MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF FUKUI   (Japan)

Author keywords

Breast cancer; COMT; Meta analysis; Polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

ARTICLE; BREAST CANCER; CANCER RISK; CATECHOL METHYLTRANSFERASE GENE; CONTROLLED STUDY; ETHNICITY; FAMILY HISTORY; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSE; MUTATOR GENE; RISK ASSESSMENT; SYSTEMATIC REVIEW;

AMINO ACID SUBSTITUTION; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, GENETIC; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBLICATION BIAS; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 84864288654     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1506-2     Document Type: Article

References (71)

1. Berns EM, van Staveren IL, Look MP, Smid M, Klijn JG, Foe-kens JA (1998) Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer. Br J Cancer 77:1130-1136 (Pubitemid 28116285)
2. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: globocan 2000. Int J Cancer 94:153-156 (Pubitemid 32911406)
3. McPherson K, Steel CM, Dixon JM (2000) ABC of breast diseases. Breast cancer epidemiology, risk factors, and genetics. BMJ 321:624-628
4. Sim X, Ali RA, Wedren S, Goh DL, Tan CS, Reilly M (2006) Ethnic differences in the time trend of female breast cancer incidence: Singapore, 1968-2002. BMC Cancer 6:261
5. de Jong MM, Nolte IM, te Meerman GJ, van der Graaf WT, Oosterwijk JC (2002) Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet 39:225-242 (Pubitemid 34496797)
6. Dunning AM, Healey CS, Pharoah PD, Teare MD, Ponder BA (1999) A systematic review of genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev 8:843-854 (Pubitemid 29508718)
7. Guldberg HC, Marsden CA (1975) Catechol-O-methyl transfer-ase: pharmacological aspects and physiological role. Pharmacol Rev 7:419-424
8. Dawling S, Roodi N, Mernaugh RL, Wang X, Parl FF (2001) Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. Cancer Res 61:6716-6722 (Pubitemid 32896493)
9. Goodman JE, Jensen LT, He P, Yager JD (2002) Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation. Pharmacogenetics 12:517-528 (Pubitemid 35177081)
10. Lavigne JA, Helzlsouer KJ, Huang HY, Strickland PT, Bell DA, Selmin O, Watson MA, Hoffman S, Comstock GW, Yager JD (1997) An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer. Cancer Res 57:5493-5497 (Pubitemid 28006754)
11. Millikan RC, Pittman GS, Tse CK, Duell E, Newman B, Savitz D, Moorman PG, Boissy RJ, Bell DA (1998) Catechol-O-methyltransferase and breast cancer risk. Carcinogenesis 19: 1943-1947 (Pubitemid 28521935)
12. Thompson PA, Shields PG, Freudenheim JL, Stone A, Vena JE, Marshall JR, Graham S, Laughlin R, Nemoto T, Kadlubar FF, Ambrosone CB (1998) Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk. Cancer Res 58:2107-2110 (Pubitemid 28232895)
13. Huang CS, Chern HD, Chang KJ, Cheng CW, Hsu SM, Shen CY (1999) Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res 59:4870-4875
14. Bergman-Jungestrom M, Wingren S (2001) Catechol-O-methyl-transferase (COMT) gene polymorphism and breast cancer risk in young women. Br J Cancer 85:859-862 (Pubitemid 33010553)
15. Goodman JE, Lavigne JA, Wu K, Helzlsouer KJ, Strickland PT, Selhub J, Yager JD (2001) COMT genotype micronutrients in the folate metabolic pathway and breast cancer risk. Carcinogenesis 22:1661-1665 (Pubitemid 32952144)
16. Hamajima N, Matsuo K, Tajima K, Mizutani M, Iwata H, Iwase T, Miura S, Oya H, Obata Y (2001) Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan. Int J Clin Oncol 6:13-18 (Pubitemid 32230357)
17. Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma VM, Benhamou S, Kang D, Vainio H, Uusitupa M, Hirvonen A (2001) Polymorphic catechol-O- methyltransferase gene and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10:635-640 (Pubitemid 32703197)
18. Yim DS, Parkb SK, Yoo KY, Yoon KS, Chung HH, Kang HL, Ahn SH, Noh DY, Choe KJ, Jang IJ, Shin SG, Strickland PT, Hirvonen A, Kang D (2001) Relationship between the Val108/158Met polymorphism of catechol-O-methyl transferase and breast cancer. Pharmacogenetics 11:279-286 (Pubitemid 32537400)
19. Kocabas NA, Sardas S, Cholerton S, Daly AK, Karakaya AE (2002) Cytochrome P450 CYP1B1 and catechol-O-methyltrans-ferase (COMT) genetic polymorphisms and breast cancer sus ceptibility in a Turkish population. Arch Toxicol 76:643-649 (Pubitemid 35471789)
20. Comings DE, Gade-Andavolu R, Cone LA, Muhleman D, MacMurray JP (2003) A multigene test for the risk of sporadic breast carcinoma. Cancer 97:2160-2170 (Pubitemid 36444056)
21. Tan W, Qi J, Xing DY, Miao XP, Pan KF, Zhang L, Lin DX (2003) Relation between single nucleotide polymorphism in estrogen-metabolizing genes COMT, CYP17 and breast cancer risk among Chinese women. Zhonghua Zhong Liu Za Zhi 25:453-456
22. Wedren S, Rudqvist TR, Granath F, Weiderpass E, Ingelman-Sundberg M, Persson I, Magnusson C (2003) Catechol-O-meth-yltransferase gene polymorphism and post-menopausal breast cancer risk. Carcinogenesis 24:681-687 (Pubitemid 36592403)
23. Wu AH, Tseng CC, Van Den Berg D, Yu MC (2003) Tea intake, COMT genotype, and breast cancer in Asian-American women. Cancer Res 63:7526-7529 (Pubitemid 37413498)
24. Ahsan H, Chen Y, Whittemore AS, Kibriya MG, Gurvich I, Senie RT, Santella RM (2004) A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk. Breast Cancer Res Treat 85:121-131 (Pubitemid 38987266)
25. Dunning AM, Dowsett M, Healey CS, Tee L, Luben RN, Folkerd E, Novik KL, Kelemen L, Ogata S, Pharoah PD, Easton DF, Day NE, Ponder BA (2004) Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 96:936-945 (Pubitemid 38868140)
26. Sazci A, Ergul E, Utkan NZ, Canturk NZ, Kaya G (2004) Cat-echol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients. Toxicology 204:197-202 (Pubitemid 39244079)
27. Cheng TC, Chen ST, Huang CS, Fu YP, Yu JC, Cheng CW, Wu PE, Shen CY (2005) Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility. Int J Cancer 113: 345-353
28. Le Marchand L, Donlon T, Kolonel LN, Henderson BE, Wilkens LR (2005) Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 14:1998-2003 (Pubitemid 41161214)
29. Lin WY, Chou YC, Wu MH, Jeng YL, Huang HB, You SL, Chu TY, Chen CJ, Sun CA (2005) Polymorphic catechol-O-methyl-transferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan. Cancer Detect Prev 29:427-432
30. Lin SC, Chou YC, Wu MH, Wu CC, Lin WY, Yu CP, Yu JC, You SL, Chen CJ, Sun CA (2005) Genetic variants of myelo-peroxidase and catechol-O-methyltransferase and breast cancer risk. Eur J Cancer Prev 14:257-261
31. Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, Cummings SR, Stone KL, Morin PA, Greene D, Cauley JA (2005) Estrogen metabolizing polymorphisms and breast cancer risk among older white women. Breast Cancer Res Treat 93:261-270 (Pubitemid 41441296)
32. Wen W, Cai Q, Shu XO, Cheng JR, Parl F, Pierce L, Gao YT, Zheng W (2005) Cytochrome P450 1B1 and catechol-O-meth-yltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis. Cancer Epidemiol Biomarkers Prev 14: 329-335 (Pubitemid 40270093)
33. Chang TW, Wang SM, Guo YL, Tsai PC, Huang CJ, Huang W (2006) Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan. Breast J 15:754-761 (Pubitemid 44774242)
34. Gallicchio L, Berndt SI, McSorley MA, Newschaffer CJ, Thuita LW, Argani P, Hoffman SC, Helzlsouer KJ (2006) Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. BMC Cancer 6:173
35. Gaudet MM, Chanock S, Lissowska J, Berndt SI, Peplonska B, Brinton LA, Welch R, Yeager M, Bardin-Mikolajczak A, Garcia-Closas M (2006) Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk. Cancer Res 66:9781-9785 (Pubitemid 44623680)
36. Gaudet MM, Bensen JT, Schroeder J, Olshan AF, Terry MB, Eng SM, Teitelbaum SL, Britton JA, Lehman TA, Neugut AI, Am-brosone CB, Santella RM, Gammonn MD (2006) Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat 99:235-240 (Pubitemid 44268273)
37. Onay VU, Briollais L, Knight JA, Shi E, Wang Y, Wells S, Li H, Rajendram I, Andrulis IL, Ozcelik H (2006) SNP-SNP interactions in breast cancer susceptibility. BMC Cancer 6:114
38. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM (2006) Prevalence of Val108/158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer. Zhonghua Wai Ke Za Zhi 44:1310-1313
39. Akisik E, Dalay N (2007) Functional polymorphism of thymi-dylate synthase, but not of the COMT and IL-1B genes, is associated with breast cancer. J Clin Lab Anal 21:97-102 (Pubitemid 46536881)
40. Ralph DA, Zhao LP, Aston CE, Manjeshwar S, Pugh TW, De-Freese DC, Gramling BA, Shimasaki CD, Jupe ER (2007) Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. Cancer 109:1940-1948 (Pubitemid 46744186)
41. Takata Y, Maskarinec G, Le Marchand L (2007) Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the multiethnic cohort. BMC Cancer 7:30
42. Pharoah PD, Tyrer J, Dunning AM et al (2007) Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet 3:e42
43. He C, Tamimi RM, Hankinson SE, Hunter DJ, Han J (2009) A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat 113:585-594
44. Onay UV, Aaltonen K, Briollais L, Knight JA, Pabalan N, Kilpivaara O, Andrulis IL, Blomqvist C, Nevanlinna H, Ozcelik H (2008) Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. BMC Cancer 8:6
45. Jakubowska A, Gronwald J, Menkiszak J, Gor'ski B, Huzarski T, Byrski T, Tołoczko-Grabarek A, Gilbert M, Edler L, Zapatka M, Eils R, Lubin'ski J, Scott RJ, Hamann U (2009) BRCA1-asso-ciated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms. Breast Cancer Res Treat 119:201-211
46. The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (2009) Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. Breast Cancer Res Treat 119:463-474
47. Reding KW, Weiss NS, Chen C, Li CI, Carlson CS, Wilkerson HW, Farin FM, Thummel KE, Daling JR, Malone KE (2009) Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk. Cancer Epidemiol Biomarkers Prev 18:1461-1467
48. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T, Brennan P, Boffetta P, Yoshida T (2009) Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer 125:837-843
49. Peterson NB, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Huang Y, Chanock SJ, Haines JL, Egan KM (2010) Association of COMT haplotypes and breast cancer risk in caucasian women. Association of COMT haplotypes and breast cancer risk in caucasian women. Anticancer Res 30:217-220
50. Wang Q, Wang YP, Li JY, Yuan P, Yang F, Li H (2010) Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study. Chin J Cancer 29:683-688
51. Delort L, Satih S, Kwiatkowski F, Bignon YJ, Bernard-Gallon DJ (2010) Evaluation of breast cancer risk in a multigenic model including low penetrance genes involved in xenobiotic and estrogen metabolisms. Nutr Cancer 62:243-251
52. Syamala VS, Syamala V, Sheeja VR, Kuttan R, Balakrishnan R, Ankathil R (2010) Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population. Cancer Invest 28:304-311
53. Cribb AE, Joy Knight M, Guernsey J, Dryer D, Hender K, Shawwa A, Tesch M, Saleh TM (2011) CYP17, catechol-o-methyltransferase, and glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on Prince Edward Island. Breast J 17:24-31
54. Cerne JZ, Pohar-Perme M, Novakovic S, Frkovic-Grazio S, Stegel V, Gersak K (2011) Combined effect of CYP1B1, COMT, GSTP1, and MnSOD genotypes and risk of postmenopausal breast cancer. J Gynecol Oncol 22:110-119
55. Hu Z, Song CG, Lu JS, Luo JM, Shen ZZ, Huang W, Shao ZM (2007) A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives. J Cancer Res Clin Oncol 133:969-978 (Pubitemid 47561713)
56. Ding HX, Fu YY, Chen WX, Wang ZW (2010) COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. Breast Cancer Res Treat 123:265-270
57. Mao C, Wang XW, Qiu LX, Liao RY, Ding H, Chen Q (2010) Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25, 627 cases and 34, 222 controls. Breast Cancer Res Treat 121:719-725
58. Davey SG, Egger M (1997) Meta-analyses of randomized controlled trials. Lancet 350:1182
59. Ioannidis JP, Boffetta P, Little J et al (2008) Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 37:120-132 (Pubitemid 351228620)
60. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. Natl Cancer Inst 22:719-778
61. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188 (Pubitemid 17189972)
62. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-1101
63. Egger M, Smith DG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634 (Pubitemid 27387172)
64. Weisz J (1994) Biogenesis of catecholestrogens: a mechanism for metabolic activation of estrogens. Polycycl Aromat Compd 6: 241-251
65. Liehr JG (1997) Dual role of oestrogens as hormones and pro-carcinogens: tumour initiation by metabolic activation of oes-trogens. Eur J Cancer Prev 6:3-10 (Pubitemid 27239511)
66. Zhu BT, Conney AH (1998) Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19:1-27 (Pubitemid 28376821)
67. Yager D, Liehr JG (1996) Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 36:203-232 (Pubitemid 26168699)
68. Butterworth NJ, Dragunow M (1996) Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transections. Brain Res Mol Brain Res 43: 1-12 (Pubitemid 27042386)
69. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-o-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharma-cogenetics 6:25-243
70. Scanlon PD, Raymond FA, Weinshilboum RM (1979) Catechol-O- methyltransferase: thermolabile enzyme in erythrocytes of subjects homozygous for allele for low activity. Science 5:63-65 (Pubitemid 9112451)
71. Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45-61 (Pubitemid 44698579)