Alpha-lipoic acid attenuates atherosclerotic lesions and inhibits proliferation of vascular smooth muscle cells through targeting of the Ras/MEK/ERK signaling pathway

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6857-6866

  Lee, Woo Ram ^a   Kim, Aekyong ^a   Kim, Kee Sik ^a   Park, Yoon Yub ^a   Park, Ji Hyun ^a   Kim, Kyung Hyun ^a   Kim, Soo Jung ^a   Park, Kwan Kyu ^a  

^a Catholic University of Daegu   (South Korea)

Author keywords

Alpha lipoic acid; Atherosclerosis; Lipopolysaccharide; VSMC

Indexed keywords

CHOLESTEROL; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAS PROTEIN; THIOCTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; MALE; MIGRATION INHIBITION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; ATHEROSCLEROSIS; CELL ADHESION MOLECULES; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DIET, ATHEROGENIC; FEMALE; LIPIDS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RAS PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; THIOCTIC ACID;

MUS;

EID: 84864277224     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1511-5     Document Type: Article

References (45)

1. Glass CK, Witztum JL (2001) Atherosclerosis, the road ahead. Cell 104(4):503-516
2. Back M, Ketelhuth DF, Agewall S (2010) Matrix metallopro-teinases in atherothrombosis. Prog Cardiovasc Dis 52(5):410-428
3. Libby P, Ridker PM, Hansson GK (2009) Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 54(23):2129-2138
4. Aukrust P, Otterdal K, Yndestad A, Sandberg WJ, Smith C, Ueland T, Oie E, Damas JK, Gullestad L, Halvorsen B (2008) The complex role of T-cell-based immunity in atherosclerosis. Curr Atheroscler Rep 10(3):236-243
5. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol 27:165-197
6. Niessner A, Goronzy JJ, Weyand CM (2007) Immune-mediated mechanisms in atherosclerosis: prevention and treatment of clinical manifestations. Curr Pharm Des 13(36):3701-3710
7. Tedgui A, Mallat Z (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 86(2):515-581
8. Lehr HA, Sagban TA, Ihling C, Zahringer U, Hungerer KD, Blumrich M, Reifenberg K, Bhakdi S (2001) Immunopathogen-esis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation 104(8):914-920 (Pubitemid 32778043)
9. Full LE, Monaco C (2010) Targeting inflammation as a therapeutic strategy in accelerated atherosclerosis in rheumatoid arthritis. Cardiovasc Ther 29(4):231-242
10. Nicholls SJ (2009) Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries. Curr Opin Lipidol 20(6):491-496
11. Kruth HS (2001) Lipoprotein cholesterol and atherosclerosis. Curr Mol Med 1(6):633-653 (Pubitemid 33772940)
12. Chapman MJ (2006) Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease. Pharmacol Ther 111(3):893-908 (Pubitemid 44164383)
13. Li M, Ong KL, Tse HF, Cheung BM (2010) Utilization of lipid lowering medications among adults in the United States 1999-2006. Atherosclerosis 208(2):456-460
14. Uno K, Nicholls SJ (2010) Statin effects on both low-density lipoproteins and high-density lipoproteins: is there a dual benefit? Curr Atheroscler Rep 12(1):14-19
15. Maher J, Yamamoto M (2010) The rise of antioxidant signaling-the evolution and hormetic actions of Nrf2. Toxicol Appl Pharmacol 244(1):4-15
16. Katsiki N, Manes C (2009) Is there a role for supplemented antioxidants in the prevention of atherosclerosis? Clin Nutr 28(1):3-9
17. Yi X, Maeda N (2006) Alpha-lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 55(8):2238-2244 (Pubitemid 44743620)
18. Zulkhairi A, Zaiton Z, Jamaluddin M, Sharida F, Mohd TH, Hasnah B, Nazmi HM, Khairul O, Zanariyah A (2008) Alpha-lipoic acid possess dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand white rabbit. Biomed Pharmacother 62(10):716-722
19. Ying Z, Kherada N, Farrar B, Kampfrath T, Chung Y, Simonetti O, Deiuliis J, Desikan R, Khan B, Villamena F, Sun Q, Partha-sarathy S, Rajagopalan S (2010) Lipoic acid effects on established atherosclerosis. Life Sci 86(3-4):95-102
20. Thompson JS (1969) Atheromata in an inbred strain of mice. J Atheroscler Res 10(1):113-122
21. Fisher-Dzoga K, Jones RM, Vesselinovitch D, Wissler RW (1973) Ultrastructural and immunohistochemical studies of primary cultures of aortic medial cells. Exp Mol Pathol 18(2): 162-176
22. Paigen B, Ishida BY, Verstuyft J, Winters RB, Albee D (1990) Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2): 316-323 (Pubitemid 20103595)
23. Nakatake J, Wasano K, Yamamoto T (1985) Three-dimensional architecture of elastic tissue in early atherosclerotic lesions of the rat aorta. Atherosclerosis 57(2-3):199-208 (Pubitemid 16235909)
24. Berbee JF, Havekes LM, Rensen PC (2005) Apolipoproteins modulate the inflammatory response to lipopolysaccharide. J Endotoxin Res 11(2):97-103 (Pubitemid 40711485)
25. Van Oosten M, Rensen PC, Van Amersfoort ES, Van Eck M, Van Dam AM, Breve JJ, Vogel T, Panet A, Van Berkel TJ, Kuiper J (2001) Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis. J Biol Chem 276(12):8820-8824
26. Zhang H, Park Y, Wu J, Chen X, Lee S, Yang J, Dellsperger KC, Zhang C (2009) Role of TNF-alpha in vascular dysfunction. Clin Sci 116(3):219-230
27. Rudijanto A (2007) The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones 39(2): 86-93
28. Willis AI, Pierre-Paul D, Sumpio BE, Gahtan V (2004) Vascular smooth muscle cell migration: current research and clinical implications. Vasc Endovasc Surg 38(1):11-23 (Pubitemid 38140268)
29. Little PJ, Ivey ME, Osman N (2008) Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis. Curr Vasc Pharmacol 6(3):195-203
30. Morikawa T, Yasuno R, Wada H (2001) Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. FEBS Lett 498(1):16-21 (Pubitemid 32522883)
31. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, So-ares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2002) Generation and initial analysis of more than 15, 000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA 99(26):16899-16903 (Pubitemid 36034070)
32. Yi X, Maeda N (2005) Endogenous production of lipoic acid is essential for mouse development. Mol Cell Biol 25(18): 8387-8392 (Pubitemid 41263026)
33. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI (2010) Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor {kappa}B and activator protein-1. Possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res 107(1):56-65
34. Huong DT, Ide T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br J Nutr 100(1):79-87
35. Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, Kim YD, Yoon TS, Jang BK, Hwang JS, Kim JB, Choi HS, Park JY, Lee IK, Lee KU (2008) Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology 48(5):1477-1486
36. Shay KP, Moreau RF, Smith EJ, Hagen TM (2008) Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life 60(6):362-367
37. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM (2009) Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 1790(10): 1149-1160
38. Zhang WJ, Bird KE, McMillen TS, LeBoeuf RC, Hagen TM, Frei B (2008) Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-428
39. Wick G, Knoflach M, Xu Q (2004) Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev Immunol 22:361-403 (Pubitemid 38680427)
40. Greene EL, Velarde V, Jaffa AA (2000) Role of reactive oxygen species in bradykinin-induced mitogen-activated protein kinase and c-fos induction in vascular cells. Hypertension 35(4): 942-947 (Pubitemid 30303955)
41. Velarde V, de la Cerda PM, Duarte C, Arancibia F, Abbott E, Gonzalez A, Moreno F, Jaffa AA (2004) Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells. Biol Res 37(3):419-430 (Pubitemid 39430133)
42. Kim HJ, Park KG, Yoo EK, Kim YH, Kim YN, Kim HS, Kim HT, Park JY, Lee KU, Jang WG, Kim JG, Kim BW, Lee IK (2007) Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells. Antioxid Redox Signal 9(3):301-307 (Pubitemid 46150964)
43. Laplante MA, Wu R, El Midaoui A, de Champlain J (2003) NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. J Hypertens 21(5):927-936 (Pubitemid 36677157)
44. Leinonen M, Saikku P (2000) Infections and atherosclerosis. Scand Cardiovasc J 34(1):12-20 (Pubitemid 30342749)
45. Espinola-Klein C, Rupprecht HJ, Blankenberg S, Bickel C, Kopp H, Rippin G, Victor A, Hafner G, Schlumberger W, Meyer J (2002) Impact of infectious burden on extent and long-term prognosis of atherosclerosis. Circulation 105(1):15-21 (Pubitemid 34049136)