The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: Large 3-substituents prevent tautomerization

Journal of Biological Chemistry

Volumn 282, Issue 50, 2007, Pages 36377-36385

  Bhowmik, Shiva ^a   Horsman, Geoff P ^b   Bolin, Jeffrey T ^a,c   Eltis, Lindsay D ^b,c  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c 1365 2350 Health Sciences Mall ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHENYL CATABOLIC (BPH) PATHWAY; CARBON-CARBON BOND HYDROLYSIS; ENOL-KETO TAUTOMERIZATION; MICROBIAL DEGRADATION;

BIODEGRADATION; CARBON; CHEMICAL BONDS; ENZYME INHIBITION; HYDROLYSIS; POLYCHLORINATED BIPHENYLS;

ENZYME ACTIVITY;

2 HYDROXY 6 OXO 6 PHENYLHEXA 2,4 DIENOIC ACID; ARGININE; HISTIDINE; HYDROLASE; POLYCHLORINATED BIPHENYL; PROTEIN BPHD; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BINDING; CHEMICAL BOND; DEGRADATION; ENZYME ENGINEERING; ENZYME INHIBITION; HYDROGEN BOND; HYDROLYSIS; MICROBIAL DEGRADATION; PRIORITY JOURNAL; STEADY STATE; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BIODEGRADATION, ENVIRONMENTAL; COMAMONAS TESTOSTERONI; ENVIRONMENTAL POLLUTANTS; FATTY ACIDS, UNSATURATED; HYDROLASES; HYDROLYSIS; ISOMERISM; KINETICS; MUTATION, MISSENSE; POLYCHLORINATED BIPHENYLS;

EID: 37549050177     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707035200     Document Type: Article

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