Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia

Clinical Lymphoma, Myeloma and Leukemia

Volumn 12, Issue 4, 2012, Pages 274-279

  Dalal, Bakul I ^a   Mansoor, Soudeh ^a   Manna, Mita ^a   Pi, Steven ^a   Di Sauro, Giovanna ^b   Hogge, Donna E ^b  

^a VANCOUVER GENERAL HOSPITAL   (Canada)

^b BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Acute myeloid leukemia; Flow cytometry; FLT3; Normal cytogenetics; NPM1

Indexed keywords

CD14 ANTIGEN; CD2 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CANCER PROGNOSIS; CYTOGENETICS; FEMALE; FLOW CYTOMETRY; FMS LIKE TYROSINE KINASE GENE 3; GENE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; IMMUNOPHENOTYPING; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MALE; NUCLEOPHOSMIN 1 GENE;

ADULT; ANTIGENS, CD; CYTOGENETICS; FEMALE; FLOW CYTOMETRY; FMS-LIKE TYROSINE KINASE 3; HUMANS; IMMUNOPHENOTYPING; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 84864262274     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2012.01.003     Document Type: Article

References (62)

1. D. Grimwade, H. Walker, F. Oliver The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial The Medical Research Council adult and children's leukaemia working parties Blood 92 1998 2322 2333
2. H. Döhner, E.H. Estey, S. Amadori Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet Blood 115 2010 453 474
3. J. Koreth, R. Schlenk, K.J. Kopecky Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials JAMA 301 2009 2349 2361
4. K. Mrózek, G. Marcucci, P. Paschka Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 109 2007 431 448
5. S.S. Farag, A.S. Ruppert, K. Mrozek Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study J Clin Oncol 23 2005 482 493
6. B. Falini, N. Bolli, A. Liso Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications Leucemia 23 2009 1731 1743
7. C. Langer, G. Marcucci, K.B. Holland Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study J Clin Oncol 27 2009 3198 3204
8. K. Döhner, H. Döhner Molecular characterization of acute myeloid leukemia Haematologica 93 2008 976 982
9. S.P. Whitman, A.S. Ruppert, M.D. Radmacher FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications Blood 111 2008 1552 1559
10. G. Marcucci, K. Maharry, M.D. Radmacher Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study J Clin Oncol 26 2008 5078 5087
11. M.A. Eid, M. Attia, S. Abdou BAALC and ERG expression in acute myeloid leukemia with normal karyotype: impact on prognosis Int J Lab Hematol 32 2010 197 205
12. D. Cilloni, A. Renneville, F. Hermitte Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study J Clin Oncol 27 2009 5195 5201
13. C.J. Strunk, U. Platzbecker, C. Thiede Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics Am J Hematol 84 2009 308 309
14. E. Paul, B. Uggla, S. Deneberg Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival Leuk Lymphoma 9 2009 1 7
15. E.C. Attar, K. Maharry, K. Mrozek Increased expression of macrophage migration inhibitory factor. (MIF) Receptor CD74 is associated with inferior outcome in younger patients (Pts) with cytogenetically normal acute myeloid leukemia (CN-AML): a Cancer and Leukemia Group B. (CALGB) Study Presented at the American Society of Hematology Annual Meeting 2009 Blood 2009 (abstract 1616)
16. R.F. Schlenk, K. Döhner, J. Krauter Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia N Engl J Med 358 2008 1909 1918
17. U. Bacher, C. Haferlach, W. Kern Prognostic relevance of FLT3-TKD mutations in AML: the combination matters - an analysis of 3082 patients Blood 111 2008 2527 2537
18. S.P. Whitman, A.S. Ruppert, G. Marcucci Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study Blood 109 2007 5164 5167
19. H. Kiyoi, T. Naoe, Y. Nakano Prognostic implication of FLT3 and N-ras gene mutations in acute myeloid leukemia Blood 93 1999 3074 3080
20. S. Lugthart, E. van Drunen, Y. van, Norden High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated Blood 111 4 2008 329 4,337
21. T. Suzuki, H. Kiyoi, K. Ozeki Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia Blood 106 2005 2854 2861
22. S. Meshinchi, W.G. Woods, D.L. Stirewalt Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia Blood 97 2001 89 94
23. S. Fröhling, R.F. Schlenk, I. Stolze CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations J Clin Oncol 22 2004 624 633
24. D. Small FLT3 mutations: biology and treatment Hematology Am Soc Hematol Educ Program 2006 178 184
25. J. Luo, C. Qi, W. Xu Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotype Am J Clin Pathol 133 2010 34 40
26. S. Schnittger, C. Schoch, W. Kern Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype Blood 106 2005 3733 3739
27. A. Jiang, H. Jiang, J. Brandwein Prognostic factors in normal karyotype acute myeloid leukemia in the absence of the FLT3-ITD mutation Leuk Res 35 2011 492 498
28. W.J. Rombouts, I. Blokland, B. Lowenberg Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene Leucemia 14 2000 675 683
29. P.D. Kottaridis, R.E. Gale, M.E. Frew The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials Blood 98 2001 1752 1759
30. K. Döhner, R.F. Schlenk, M. Habdank Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations Blood 106 2005 3740 3746
31. R.E. Gale, C. Green, C. Allen The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia Blood 111 2008 2776 2784
32. W. Chen, G.Z. Rassidakis, J. Li High frequency of NPM1 gene mutations in acute myeloid leukemia with prominent nuclear invaginations ('cuplike' nuclei) Blood 108 2006 1783 1784
33. S.J. Kussick, D.L. Stirewalt, H.S. Yi A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication Leucemia 18 2004 1591 1598
34. W. Chen, S. Konoplev, L.J. Medeiros Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation Cancer 115 2009 5481 5489
35. B. Falini, C. Mecucci, E. Tiacci Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype N Engl J Med 352 2005 254 266
36. W. Chen, G.Z. Rassidakis, L.J. Medeiros Nucleophosmin gene mutations in acute myeloid leukemia Arch Pathol Lab Med 130 2006 1687 1692
37. S. Konoplev, X. Huang, H.A. Drabkin Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis Cancer 115 2009 4737 4744
38. Y. Mori, G. Yoshimoto, T. Kumano Distinctive expression of myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation Eur J Haematol 79 2007 17 24
39. L. Yan, S. Chen, J. Liang Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia Int J Hematol 86 2007 143 146
40. W.C. Chou, J.L. Tang, L.I. Lin Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution Cancer Res 66 2006 3310 3316
41. J. Nomdedeu, E. Bussaglia, N. Villamor Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size Leuk Res 35 2011 163 168
42. L. Muñoz, A. Aventín, N. Villamor Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication Haematologica 88 2003 637 645
43. M. Alcalay, E. Tiacci, R. Bergomas Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance Blood 106 2005 899 902
44. V. Rausei-Mills, K.L. Chang, K.K. Gaal Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation Am J Clin Pathol 129 2008 624 629
45. P.S. Chauhan, B. Bhushan, A.K. Mishra Mutation of FLT3 gene in acute myeloid leukemia with normal cytogenetics and its association with clinical and immunophenotypic features Med Oncol 28 2011 544 551
46. H. Khoury, B.I. Dalal, T.J. Nevill Acute myelogenous leukemia with t(8;21) - identification of a specific immunophenotype Leuk Lymphoma 44 2003 1713 1718
47. L.E. Ailles, B. Gerhard, H. Kawagoe Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice Blood 94 1999 1761 1772
48. H.J. Kang, S.H. Hong, I.H. Kim Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia Leuk Res 29 2005 617 623
49. A.R. Brooks-Wilson, P. Kaurah, G. Suriano Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria J Med Genet 41 2004 508 517
50. D. Gordon, C. Abajian, P. Green Consed: a graphical tool for sequence finishing Genome Res 8 1998 195 202
51. C. Haferlach, C. Mecucci, S. Schnittger AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biological, pathological, immunophenotypic, and prognostic features Blood 114 2009 3024 3032
52. B.I. Dalal, V. Wu, M.J. Barnett Induction failure in de novo acute myelogenous leukemia is associated with expression of high levels of CD34 antigen by the leukemic blasts Leuk Lymphoma 26 1997 299 306
53. H. Chang, F. Salma, Q.L. Yi Prognostic relevance of immunophenotyping in 379 patients with acute myeloid leukemia Leuk Res 28 2004 43 48
54. C. Plesa, Y. Chelghoum, A. Plesa Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience Cancer 112 2008 572 580
55. H. Chang, J. Yeung, J. Brandwein CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotype Leuk Res 31 2007 157 162
56. C. Chabannon, P. Wood, B. Torok-Storb Expression of CD7 on normal human myeloid progenitors J Immunol 149 1992 2110 2113
57. G. Del Poeta, R. Stasi, A. Venditti CD7 expression in acute myeloid leukemia Leuk Lymphoma 17 1995 111 119
58. S. Schnittger, C. Schoch, M. Dugas Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease Blood 100 2002 59 66
59. L. Wang, D. Lin, X. Zhang Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients Leuk Res 29 2005 1393 1398
60. F. Schneider, E. Hoster, M. Unterhalt Age-dependent frequencies of NPM-1/FLT3-ITD mutations in patients with normal karyotype AML Presented At The Annual Meeting of the American Society of Hematology 2008 Blood 2008 (Abstract 2531)
61. B. Khanlari, A. Buser, A. Lugli The expression pattern of CD56 (N-CAM) in human bone marrow biopsies infiltrated by acute leukemia Leuk Lymphoma 44 2003 2055 2059
62. A. Venditti, G. Del Poeta, F. Buccisano Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia Leucemia 12 1998 1056 1063