An optimization-based study of equivalent circuit models for representing recordings at the neuron-electrode interface

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 8, 2012, Pages 2338-2347

  Thakore, Vaibhav ^a   Molnar, Peter ^a,b   Hickman, James J ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b UNIVERSITY OF WEST HUNGARY   (Hungary)

Author keywords

Microelectrode arrays (MEAs); neuroelectronic interface; nonlinear ionic electrodiffusion; whole cell biosensors

Indexed keywords

CONTACT MODELS; ELECTRIC DOUBLE LAYER; ELECTRODIFFUSION; ELECTROPHYSIOLOGICAL RECORDINGS; EQUIVALENT CIRCUIT MODEL; EXTRACELLULAR; EXTRACELLULAR RECORDING; EXTRACELLULAR SIGNALS; IONIC TRANSPORTS; MICROELECTRODE ARRAY; MODEL PARAMETERS; NEURAL PROSTHETIC; RECORDED SIGNALS; SINGLE NEURON; SUPRATHRESHOLD; WHOLE-CELL BIOSENSORS;

BIOSENSORS; CIRCUIT THEORY; DIFFUSION; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; EQUIVALENT CIRCUITS; MICROELECTRODES; OPTIMIZATION; SIGNAL TRANSDUCTION;

NEURONS;

ARTICLE; ELECTRIC CURRENT; ELECTRODE; ELECTROPHYSIOLOGY; EXTRACELLULAR SIGNAL; ION TRANSPORT; NERVE CELL; RECORDING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; ELECTROPHYSIOLOGICAL PHENOMENA; EQUIPMENT DESIGN; EXTRACELLULAR SPACE; MICE; MICROELECTRODES; MODELS, NEUROLOGICAL; NEURONS; PATCH-CLAMP TECHNIQUES; RATS;

EID: 84864256539     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2012.2203820     Document Type: Article

References (35)

1. W. L. C. Rutten, J. P. A. Smit, T. A. Frieswijk, J. A. Bielen, A. L. H. Brouwer, J. R. Buitenweg, and C. Heida, "Neuro-electronic interfacing with multielectrode arrays\-Selectivity and efficiency of motor-fiber stim-ulation, toward a cultured probe," IEEE Eng. Med. Biol. Mag., vol. 18, no. 3, pp. 47-55, May/Jun. 1999. (Pubitemid 29227896)
2. K. Varghese, P. Molnar, M. Das, N. Bhargava, S. Lambert, M. S. Kindy, and J. J. Hickman, "A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology," PloS One, vol. 5, p. e8643, Jan. 2010.
3. A. Natarajan, P. Molnar, K. Sieverdes, A. Jamshidi, and J. J. Hickman, "Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity," Toxicol. Vitro, vol. 20, pp. 375-381, Apr. 2006. (Pubitemid 43343769)
4. L. Bousse, "Whole cell biosensors," Sens. Actuators B, Chem., vol. 34, pp. 270-275, Aug. 1996. (Pubitemid 126379872)
5. M. P. Bonomini, J. M. Ferrandez, and E. Fernandez, "Searching for se-mantics in the retinal code," Neurocomputing, vol. 72, pp. 806-813, Jan. 2009.
6. S. Ingebrandt, C. K. Yeung, M. Krause, and A. Offenhausser, "Neuron-transistor coupling: Interpretation of individual extracellular recorded sig-nals," Eur. Biophys. J. Biophys. Lett., vol. 34, pp. 144-154, Mar. 2005. (Pubitemid 40487355)
7. M. J. Ignatius, N. Sawhney, A. Gupta, B. M. Thibadeau, O. R. Monteiro, and I. G. Brown, "Bioactive surface coatings for nanoscale instruments: Effects on CNS neurons," J. Biomed. Mater. Res., vol. 40, pp. 264-274, 1998.
8. D. R. Jung, D. S. Cuttino, J. J. Pancrazio, P. Manos, T. Cluster, R. S. Sathanoori, L. E. Aloi, M. G. Coulombe, M. A. Czamaski, D. A. Borkholder, G. T. A. Kovacs, P. Bey, D. A. Stenger, and J. J. Hick-man, "Cell-based sensor microelectrode array characterized by imaging x-ray photoelectron spectroscopy, scanning electron microscopy, impedance measurements, and extracellular recordings," J. Vacuum Sci. Technol. A, VacuumSurfacesFilms, vol. 16,pp. 1183-1188, 1998.
9. M. Stelzle, R. Wagner, W. Nisch, W. Jagermann, R. Frohlich, and M. Schal-dach, "On the chemical modification of pacemaker electrodes and pat-terned surface functionalization of planar substrates," Biosens. Bioelec-tron., vol. 12, pp. 853-865, 1997. (Pubitemid 28015299)
10. A. Mazzatenta, M. Giugliano, S. Campidelli, L. Gambazzi, L. Businaro, H. Markram, M. Prato, and L. Ballerini, "Interfacing neurons with carbon nanotubes: Electrical signal transfer and synaptic stimulation in cultured brain circuits," J. Neurosci., vol. 27, pp. 6931-6936, Jun. 27, 2007. (Pubitemid 47015886)
11. M. Thein, F Asphahani, A. Cheng, R. Buckmaster, M. Q. Zhang, and J. Xu, "Response characteristics of single-cell impedance sensors em-ployed with surface-modified microelectrodes," Biosens. Bioelectron., vol. 25, pp. 1963-1969, Apr. 2010.
12. R. Weis and P. Fromherz, "Frequency dependent signal transfer in neuron transistors," Phys. Rev. E, vol. 55, pp. 877-889, Jan. 1997. (Pubitemid 127736178)
13. A. Offenhausser and W. Knoll, "Cell-transistor hybrid systems and their potential applications," Trends Biotechnol., vol. 19, pp. 62-66, 2001. (Pubitemid 32112683)
14. S. Martinoia, P. Massobrio, M. Bove, and G. Massobrio, "Cultured neurons coupled to microelectrode arrays: Circuit models, simulations and exper-imental data," IEEE Trans. Biomed. Eng., vol. 51, no. 5, pp. 859-864, May 2004. (Pubitemid 38525721)
15. M. Bove, S. Martinoia, M. Grattarola, andD. Ricci, "Theneuron- transistor junction: Linking equivalent electric circuit models to microscopic de-scriptions," Thin Solid Films, vol. 285, pp. 772-775, Sep. 1996. (Pubitemid 126387486)
16. J. Buitenweg, W. L. C. Rutten, and E. Marani, "Geometry-based finite-element modeling of the electrical contact between a cultured neuron and amicroelectrode," IEEETrans.Biomed.Eng.,vol.50,no. 4,pp. 501-509, Apr. 2003. (Pubitemid 36438228)
17. N. Joye, A. Schmid, and Y. Leblebici, "Electrical modeling of the cell-electrode interface for recording neural activity from high-density micro-electrode arrays," Neurocomputing, vol. 73, pp. 250-259, Dec. 2009.
18. M. Brittinger and P. Fromherz, "Field-effect transistor with recombinant potassium channels: Fast and slow response by electrical and chemical interactions," Appl. Phys. A, Mater. Sci. Process., vol. 81, pp. 439-447, Aug. 2005. (Pubitemid 40925159)
19. M. Pabst, G. Wrobel, S. Ingebrandt, F. Sommerhage, and A. Offenhausser, "Solution of the Poisson\-Nernst-Planck equations in the cell-substrate interface," Eur. Phys. J. E, vol. 24, pp. 1-8, Sep. 2007.
20. G. Wrobel, R. Seifert, S. Ingebrandt, J. Enderlein, H. Ecken, A. Baumann, U. B. Kaupp, andA. Offenhausser, "Cell-transistorcoupling: Investigation ofpotassium currents recorded with p- and n-channel FETs," Biophys. J., vol. 89, pp. 3628-3638, Nov. 2005. (Pubitemid 41636114)
21. V. Thakore, A. Behal, P. Molnar, D. C. Leistritz, and J. J. Hickman, "Nanoscale nonlinear dynamic characterization of the neuron-electrode junction," J. Comput. Theor. Nanosci., vol. 5, pp. 2164-2169, Nov. 2008.
22. M. Jenkner and P. Fromherz, "Bistability of membrane conductance in cell adhesion observed in a neuron transistor," Phys. Rev. Lett., vol. 79, pp. 4705-4708, Dec. 1997. (Pubitemid 127645307)
23. R. Schatzthauer and P. Fromherz, "Neuron-silicon junction with voltage-gated ionic currents," Eur. J. Neurosci., vol. 10, pp. 1956-1962, 1998. (Pubitemid 28327343)
24. P. Fromherz, "Extracellular recording with transistors and the distribution of ionic conductances in a cell membrane," Eur. Biophys. J. Biophys. Lett., vol. 28, pp. 254-258, 1999. (Pubitemid 29225603)
25. J. R. Buitenweg, W. L. C. Rutten, and E. Marani, "Modeled channel distributions explain extracellularrecordings from cultured neurons sealed to microelectrodes," IEEE Trans. Biomed. Eng., vol. 49, no. 12, pp. 1580-1590, Dec. 2002. (Pubitemid 36055716)
26. W. Ma, J. J. Pancrazio, M. Coulombe, J. Dumm, R. Sathanoori, J. L. Barker, V. C. Kowtha, D. A. Stenger, and J. J. Hickman, "Neuronal and glial epitopes and transmitter-synthesizing enzymes appear in parallel with membrane excitability during neuroblastomaxglioma hybrid differ-entiation," Develop. Brain Res., vol. 106, pp. 155-163, 1998. (Pubitemid 28168481)
27. A. L. Hodgkin and A. F Huxley, "A quantitative description of membrane current and its application to conduction and excitation in nerve," J. Physiol., vol. 117, pp. 500-544, 1952.
28. D. K. Mohan, P. Molnar, and J. J. Hickman, "Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells," Biosens. Bioelectron., vol. 21, pp. 1804-1811, Mar. 2006. (Pubitemid 43256693)
29. A. Destexhe and J. R. Huguenard, "Nonlinear thermodynamic models of voltage-dependent currents," J. Comput. Neurosci., vol. 9, pp. 259-270, Nov. 2000. (Pubitemid 32000323)
30. T. Gabay, M. Ben-David, I. Kalifa, R. Sorkin, Z. R. Abrams, E. Ben-Jacob, and Y. Hanein, "Electro-chemical and biological properties of carbon nanotube based multi-electrode arrays," Nanotechnology, vol. 18, p. 6, Jan. 2007. Online. Available: http://www.multichannelsystems.com.
31. V. S. Muralidharan, "Warburg impedance\-Basics revisited," Anti-Corrosion Methods Mater., vol. 44, pp. 26-29, 1997.
32. J. R. Buitenweg, W. L. C. Rutten, E. Marani, S. K. L. Polman, and J. Ur-sum, "Extracellular detection of active membrane currents in the neuron-electrode interface," J. Neurosci. Methods, vol. 115, pp. 211-221, Apr. 15, 2002. (Pubitemid 34464098)
33. F. Patolsky, B. P. Timko, G. H. Yu, Y. Fang, A. B. Greytak, G. F Zheng, and C. M. Lieber, "Detection, stimulation, and inhibition of neuronal signals with high-density nanowire transistor arrays," Science, vol. 313, pp. 1100-1104, Aug. 2006. (Pubitemid 44300231)
34. F. Patolsky, G. Zheng, and C. M. Lieber, "Nanowire sensors for medicine and the life sciences," Nanomedicine, vol. 1, pp. 51-65, Jun. 2006.
35. N. A. Kotov, J. O. Winter, I. P. Clements, E. Jan, B. P. Timko, S. Campi-delli, S. Pathak, A. Mazzatenta, C. M. Lieber, M. Prato, R. V. Bellamkonda, G. A. Silva, N. W. S. Kam, F. Patolsky, and L. Ballerini, "Nanomaterials for Neural Interfaces," Adv. Mater., vol. 21, pp. 3970-4004, Oct. 2009.