Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 9, 2012, Pages 2001-2009

  Shiota, Masayuki ^a   Hikita, Yuko ^a   Kawamoto, Yukiko ^a   Kusakabe, Hiromi ^a   Tanaka, Masako ^a   Izumi, Yasukatsu ^a   Nakao, Takafumi ^a   Miura, Katsuyuki ^a   Funae, Yoshihiko ^a   Iwao, Hiroshi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Endothelial cells; FGF 2; Pleiotropic effect; Statin

Indexed keywords

3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; ANGIOGENIC FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PRAVASTATIN; PROTEIN KINASE B; PYRROLE DERIVATIVE;

ARTICLE; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INDUCING AGENTS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLAST GROWTH FACTOR 2; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PRAVASTATIN; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 84864233386     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01494.x     Document Type: Article

References (30)

1. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation. 2000; 101: 207-13.
2. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001; 21: 1712-9.
3. Undas A, Brummel-Ziedins KE, Mann KG. Statins and blood coagulation. Arterioscler Thromb Vasc Biol. 2005; 25: 287-94.
4. Izumi Y, Shiota M, Kusakabe H, et al Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase. Hypertens Res. 2009; 32: 675-9.
5. Kureishi Y, Luo Z, Shiojima I, et al The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000; 6: 1004-10.
6. Weis M, Heeschen C, Glassford AJ, et al Statins have biphasic effects on angiogenesis. Circulation. 2002; 105: 739-45.
7. Urbich C, Dernbach E, Zeiher AM, et al Double-edged role of statins in angiogenesis signaling. Circ Res. 2002; 90: 737-44.
8. Virdis A, Colucci R, Versari D, et al Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids. Hypertension. 2009; 53: 1008-16.
9. Downs JR, Clearfield M, Weis S, et al Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998; 279: 1615-22.
10. Kaesemeyer WH, Caldwell RB, Huang J, et al Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions. J Am Coll Cardiol. 1999; 33: 234-41.
11. Shiota M, Kusakabe H, Hikita Y, et al Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin - an experimental elucidation of the pharmacologic action from protein-protein interaction analysis. J Pharmacol Sci. 2008; 107: 15-9.
12. Fujio Y, Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem. 1999; 274: 16349-54.
13. Qi JH, Matsumoto T, Huang K, et al Phosphoinositide 3 kinase is critical for survival, mitogenesis and migration but not for differentiation of endothelial cells. Angiogenesis. 1999; 3: 371-80.
14. Suri C, Jones PF, Patan S, et al Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996; 87: 1171-80.
15. Shiota M, Kusakabe H, Izumi Y, et al Heat shock cognate protein 70 is essential for Akt signaling in endothelial function. Arterioscler Thromb Vasc Biol. 2010; 30: 491-7.
16. Ghosh-Choudhury N, Mandal CC, Choudhury GG. Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. J Biol Chem. 2007; 282: 4983-93.
17. Nakao T, Shiota M, Tatemoto Y, et al Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. J Pharmacol Sci. 2007; 105: 334-41.
18. Rhoads DN, Eskin SG, McIntire LV. Fluid flow releases fibroblast growth factor-2 from human aortic smooth muscle cells. Arterioscler Thromb Vasc Biol. 2000; 20: 416-21.
19. Hoffman R, Paper DH, Donaldson J, et al Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation. J Cell Sci. 1995; 108 (Pt 11): 3591-8.
20. Bikfalvi A, Klein S, Pintucci G, et al Biological roles of fibroblast growth factor-2. Endocr Rev. 1997; 18: 26-45.
21. Donnini S, Solito R, Giachetti A, et al. Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium. J Pharmacol Exp Ther. 2006; 319: 515-22.
22. Mata-Greenwood E, Liao WX, Zheng J, et al Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cells. Placenta. 2008; 29: 708-17.
23. Miyamoto T, Leconte I, Swain JL, et al Autocrine FGF signaling is required for vascular smooth muscle cell survival in vitro. J Cell Physiol. 1998; 177: 58-67.
24. Yayon A, Klagsbrun M, Esko JD, et al Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991; 64: 841-8.
25. Quarto N, Amalric F. Heparan sulfate proteoglycans as transducers of FGF-2 signalling. J Cell Sci. 1994; 107: 3201-12.
26. Klagsbrun M. Mediators of angiogenesis: the biological significance of basic fibroblast growth factor (bFGF)-heparin and heparan sulfate interactions. Semin Cancer Biol. 1992; 3: 81-7.
27. Rapraeger AC, Krufka A, Olwin BB. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science. 1991; 252: 1705-8.
28. Kolesnikova TV, Lau LF. Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene. 1998; 16: 747-54.
29. Czubayko F, Liaudet-Coopman ED, Aigner A, et al A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat Med. 1997; 3: 1137-40.
30. Soltys CL, Buchholz L, Gandhi M, et al Phosphorylation of cardiac protein kinase B is regulated by palmitate. Am J Physiol Heart Circ Physiol. 2002; 283: H1056-64.