N-terminally glutamate-substituted analogue of gramicidin A as protonophore and selective mitochondrial uncoupler

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Sorochkina, Alexandra I ^a   Plotnikov, Egor Y ^a   Rokitskaya, Tatyana I ^a   Kovalchuk, Sergei I ^b   Kotova, Elena A ^a   Sychev, Sergei V ^b   Zorov, Dmitry B ^a   Antonenko, Yuri N ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CARBOXYLIC ACID; GLUTAMIC ACID; GRAMICIDIN A; GRAMICIDIN A DERIVATIVE; GRAMICIDIN DERIVATIVE; IONOPHORE; PROTONOPHORE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; DEPOLARIZATION; LIPID BILAYER; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; ELECTRICITY; GLUTAMIC ACID; GRAMICIDIN; HYDROGEN-ION CONCENTRATION; ION CHANNELS; KIDNEY; LIPID BILAYERS; LIPOSOMES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MOLECULAR SEQUENCE DATA; PEPTIDES; PHENAZINES; PROTON IONOPHORES; RATS; UNCOUPLING AGENTS;

EID: 84864209699     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041919     Document Type: Article

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