Modulation of PC12 cell viability by forskolin-induced cyclic AMP levels through ERK and JNK pathways: An implication for L-DOPA-induced cytotoxicity in nigrostriatal dopamine neurons

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 247-257

  Park, Keun Hong ^a   Park, Hyun Jin ^a   Shin, Keon Sung ^a   Choi, Hyun Sook ^a   Kai, Masaaki ^b   Lee, Myung Koo ^a  

^a Chungbuk National University   (South Korea)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

cell viability; Cyclic AMP; ERK; forskolin; JNK; PC12 cells

Indexed keywords

CASPASE 3; CYCLIC AMP; FORSKOLIN; LEVODOPA; MITOGEN ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE 1; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; PARKINSON DISEASE;

ANIMALS; CELL SURVIVAL; CORPUS STRIATUM; CYCLIC AMP; DOPAMINE; FORSKOLIN; LEVODOPA; MAP KINASE SIGNALING SYSTEM; NEURONS; PC12 CELLS; PHOSPHORYLATION; RATS; SUBSTANTIA NIGRA;

EID: 84864203701     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs139     Document Type: Article

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