The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor

Neuroscience Letters

Volumn 297, Issue 2, 2001, Pages 133-136

  Lambeng, Nathalie ^a   Michel, Patrick P ^a   Agid, Yves ^a   Ruberg, Merle ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Cyclic adenosine monophosphate; Epidermal growth factor; Nerve growth factor; PC12 cells; Trophic factor withdrawal

Indexed keywords

CYCLIC AMP; EPIDERMAL GROWTH FACTOR; NERVE GROWTH FACTOR; OLOMOUCINE; PROTEIN TYROSINE KINASE; ROSCOVITINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; MITOSIS; NERVE CELL DIFFERENTIATION; NEURITE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; CYCLIC AMP; DIBUTYRYL CYCLIC GMP; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FORSKOLIN; KINETIN; NERVE GROWTH FACTOR; NEURONS; PC12 CELLS; PURINES; RATS;

EID: 0035846839     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01690-6     Document Type: Article

References (17)

1. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells
2. Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support
3. Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells
4. Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells
5. EGF in combination with depolarization or cAMP produces morphological but not physiological differentiation in PC12 cells
6. Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor
7. Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP
8. The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21(ras)G protein, and pp60(c-src) cytoplasmic tyrosine kinase
9. Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors
10. Coupling of epidermal growth factor (EGF) with the antiproliferative activity of cAMP induces neuronal differentiation
11. Synergistic differentiation by chronic exposure to cyclic AMP and nerve growth factor renders rat phaechromocytoma PC12 cells totally dependent upon trophic support for survival
12. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
13. Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death
14. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
15. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
16. Synergistic induction of neurite outgrowth by nerve growth factor or epidermal growth factor and interleukin-6 in PC12 cells
17. Cyclic adenosine monophosphate can convert epidermal growth factor into a differentiating factor in neuronal cells