The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Jung, Kwonil ^a   Wang, Qiuhong ^a   Kim, Yunjeong ^b   Scheuer, Kelly ^a   Zhang, Zhenwen ^a   Shen, Quan ^a   Chang, Kyeong Ok ^b   Saif, Linda J ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; POLYINOSINIC POLYCYTIDYLIC ACID; SIMVASTATIN; TOLL LIKE RECEPTOR 3; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARTICLE; DENDRITIC CELL; DRUG EFFICACY; DRUG INHIBITION; DRUG MEGADOSE; GNOTOBIOTICS; IMMUNOMODULATION; IN VITRO STUDY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MACROPHAGE; MONOTHERAPY; NONHUMAN; NOROVIRUS; NOROVIRUS INFECTION; NUCLEOTIDE SEQUENCE; PIGLET; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPLICON; RISK REDUCTION; TREATMENT DURATION; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS SHEDDING;

ANIMALS; ANTIVIRAL AGENTS; BLOOD GROUP ANTIGENS; CALICIVIRIDAE INFECTIONS; CHOLESTEROL; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ENTEROCYTES; FECES; GENE EXPRESSION REGULATION; GERM-FREE LIFE; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-ALPHA; INTESTINES; MACROPHAGES; NF-KAPPA B; NOROVIRUS; PHENOTYPE; RECEPTORS, LDL; SIMVASTATIN; SUS SCROFA; TOLL-LIKE RECEPTOR 3; VIRAL LOAD; VIRUS REPLICATION; VIRUS SHEDDING;

ANIMALIA; NOROVIRUS; SUIDAE;

EID: 84864200009     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041619     Document Type: Article

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