Structural and functional changes of the duodenum in human norovirus infection

Gut

Volumn 58, Issue 8, 2009, Pages 1070-1077

  Troeger, H ^a   Loddenkemper, C ^a   Schneider, T ^a   Schreier, E ^b   Epple, H J ^a   Zeitz, M ^a   Fromm, M ^a   Schulzke, J D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; ANION; BUMETANIDE; CLAUDIN 4; CLAUDIN 5; MANNITOL; OCCLUDIN; PERFORIN;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DUODENUM; DUODENUM BIOPSY; ELECTRIC RESISTANCE; FECES ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; INFECTIOUS DIARRHEA; INTESTINE CELL; INTESTINE ENDOSCOPY; INTESTINE SECRETION; INTESTINE VILLUS; LYMPHOCYTE; LYMPHOCYTE COUNT; MICRODISSECTION; NOROVIRUS; NOROVIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SHORT CIRCUIT CURRENT; SMALL INTESTINE ABSORPTION; SMALL INTESTINE MUCOSA; SPECTROSCOPY; STAINING; TIGHT JUNCTION; VIRUS INFECTION;

ACUTE DISEASE; APOPTOSIS; BIOPSY; BLOTTING, WESTERN; CALICIVIRIDAE INFECTIONS; DIFFUSION CHAMBERS, CULTURE; DUODENUM; GASTROENTERITIS; HUMANS; INTESTINAL MUCOSA; MANNITOL; TIGHT JUNCTIONS;

EID: 67650239559     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.160150     Document Type: Article

References (49)

1. Glass RI, Bresee J, Jiang B, et al. Gastroenteritis viruses: an overview. Novartis Found Symp 2001;238:4-19.
2. Kapikian AZ, Wyatt RG, Dolin R, et al. Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J Virol 1972;10:1075-81.
3. Dolin R, Blacklow NR, DuPont H, et al. Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis. Proc Soc Exp Biol Med 1972;140:578-83.
4. Mattner F, Sohr D, Heim A, et al. Risk groups for clinical complications of norovirus infections: an outbreak investigation. Clin Microbiol Infect 2006;12:69-74.
5. Gray JJ, Kohli E, Ruggeri FM, et al. European multicenter evaluation of commercial enzyme immunoassays for detecting norovirus antigen in fecal samples. Clin Vaccine Immunol 2007;14:1349-55.
6. Guix S, Asanaka M, Katayama K, et al. Norwalk virus RNA is infectious in mammalian cells. J Virol 2007;81:12238-48.
7. Straub TM, Höner zu Bentrup K, Orosz-Coghlan P, et al. In vitro cell culture infectivity assay for human noroviruses. Emerg Infect Dis 2007;13:396-403.
8. Agus AG, Dolin R, Wyatt RG, et al. Acute infectious nonbacterial gastroenteritis: intestinal histopathology. Ann Intern Med 1973;79:18-25.
9. Schreiber DS, Blacklow NR, Trier JS. The mucosal lesion of the proximal small intestine in acute infectious nonbacterial gastroenteritis. N Engl J Med 1973;21:1318-22.
10. Tan M, Jiang X. Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle. Trends Microbiol 2005;13:285-93.
11. Karst SM, Wobus CE, Lay M, et al. STAT1-dependent innate immunity to a Norwalklike virus. Science 2003;7:1575-8.
12. Mumphrey SM, Changotra H, Moore TN, et al. Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses. J Virol 2007;81:3251-63.
13. Mueller B, Klemm U, Mas Marques A, et al. Genetic diversity and recombination of murine noroviruses in immunocompromised mice. Arch Virol 2007;152:1709-19.
14. Cheetham S, Souza M, Meulia T, et al. Pathogenesis of a genogroup II human norovirus in gnotobiotic pigs. J Virol 2006;80:10372-81.
15. Stockmann M, Fromm M, Schmitz H, et al. Duodenal biopsies of HIV-infected patients with diarrhea exhibit epithelial barrier defects but no active secretion. AIDS 1998;12:43-51.
16. Schreier E, Döring F, Künkel U. Molecular epidemiology of outbreaks of gastroenteritis associated with small round structured viruses in Germany in 1997/98. Arch Virol 2000;145:443-53.
17. Oh D, Gaedicke G, Schreier E. Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol 2003;71:82-93.
18. Hoehne M, Schreier E. Detection of norovirus genogroup I and II by multiplex realtime RT- PCR using a 39-minor groove binder-DNA probe. BMC Infect Dis 2006;6:69.
19. Schulzke JD, Fromm M, Bentzel CJ, et al. Epithelial ion transport in the experimental short bowel syndrome of the rat. Gastroenterology 1992;102:497-504.
20. Gitter AH, Schulzke JD, Sorgenfrei D, et al. Ussing chamber for high-frequency transmural impedance analysis of epithelial tissues. J Biochem Biophys Methods 1997;35:81-8.
21. Tai YH, Tai CY. The conventional short-circuiting technique under-short-circuits most epithelia. J Membr Biol 1981;59:173-7.
22. Fromm M, Schulzke JD, Hegel U. Epithelial and subepithelial contributions to transmural electrical resistance of intact rat jejunum, in vitro. Pflugers Arch 1985;405:400-2.
23. Schulzke JD, Fromm M, Menge H, et al. Impaired intestinal sodium and chloride transport in the blind loop syndrome of the rat. Gastroenterology 1987;92:693-8.
24. Chang F, Mahadeva U, Deere H. Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa. APMIS 2005;113:385-99.
25. Lundqvist C, Melgar S, Yeung MM, et al. Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions. J Immunol 1996;157:1926-34.
26. James SP. The gastrointestinal mucosal immune system. Dig Dis 1993;11:146-56.
27. Kewenig S, Schneider T, Hohloch K, et al. Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques. Gastroenterology 1999;116:1115-23.
28. Troeger H, Epple HJ, Schneider T, et al. Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut 2007;56:328-35.
29. Moore R, Pothoulakis C, LaMont JT, et al. C. difficile toxin A increases intestinal permeability and induces Cl- secretion. Am J Physiol 1990;259:G165-72.
30. Fasano A, Baudry B, Pumplin DW, et al. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci USA 1991;88:5242-6.
31. Tafazoli F, Zeng CQ, Estes MK, et al. NSP4 enterotoxin of rotavirus induces paracellular leakage in polarized epithelial cells. J Virol 2001;75:1540-6.
32. Nava P, López S, Arias CF, et al. The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci 2004;117:5509-19.
33. Van Itallie C, Rahner C, Anderson JM. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 2001;107:1319-27.
34. Amasheh S, Schmidt T, Mahn M, et al. Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tissue Res 2005;32:89-96.
35. Wen H, Watry DD, Marcondes MC, et al. Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol 2004;24:8408-17.
36. Moser LA, Carter M, Schultz-Cherry S. Astrovirus increases epithelial barrier permeability independently of viral replication. J Virol 2007;81:11937-45.
37. Beau I, Cotte-Laffitte J, Amsellem R, et al. A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junction-associated protein, occludin, in human differentiated intestinal Caco-2 cells. J Virol 2007;81:8579-86.
38. Obert G, Peiffer I, Servin AL. Rotavirus-induced structural and functional alterations in tight junctions of polarized intestinal Caco-2 cell monolayers. J Virol 2000;74:4645-51.
39. Schulzke JD, Gitter AH, Mankertz J, et al. Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta 2005;1669:34-42.
40. Coyne CB, Shen L, Turner JR, et al. Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host Microbe 2007;2:181-92.
41. Gitter AH, Bendfeldt K, Schulzke JD, et al. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J 2000;14:1749-53.
42. Mankertz J, Hillenbrand B, Günzel D, et al. Norovirus non-structural protein p20 leads to epithelial barrier dysfunction by inhibition of actin cytoskeleton remodelling. Gastroenterology 2007;132:A- 714,W1572.
43. Merger M, Viney JL, Borojevic R, et al. Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine. Gut 2002;51:155-63.
44. Souza M, Azevedo MSP, Jung K, et al. Pathogenesis and immune response in gnotobiotic calves after infection with the genogroup II.4-HS66 strain of human norovirus. J Virol 2008;82:1777-86.
45. Xu X, Fu XY, Plate J, et al. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res 1998;58:2832- 7.
46. Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989;83:724-7.
47. Zeissig S, Bürgel N, Günzel D, et al. Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007;56:61-72.
48. Kimberg DV, Field M, Johnson J, et al. Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J Clin Invest 1971;50:1218-30.
49. Levy AG, Widerlite L, Schwartz CJ, et al. Jejunal adenylate cyclase activity in human subjects during viral gastroenteritis. Gastroenterology 1976;70:321-325.