Preliminary safety evaluation of novel small molecule inhibitors of caspase-3

Journal of Chemical and Pharmaceutical Research

Volumn 4, Issue 6, 2012, Pages 3129-3133

  Samiulla, D S ^a   Naidu, A ^b   Ramachandra, M ^a  

^a Aurigene Discovery Technologies Limited   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Caspase 3 inhibitors; Safety assessment; Small molecule

Indexed keywords

BODY WEIGHT; CASPASE-3; CASPASES; CYTOTOXICITY TEST; HEPATOCYTES; IN-VITRO; IN-VITRO TESTS; IN-VIVO; PHARMACOLOGICALLY ACTIVE COMPOUNDS; PRIMARY HEPATOCYTES; PROGRAMMED CELL DEATHS; SAFETY ASSESSMENTS; SAFETY EVALUATIONS; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

CELL DEATH; SAFETY ENGINEERING; THREE DIMENSIONAL;

MOLECULES;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 3 INHIBITOR; EMRICASAN; FLAVOPIRIDOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; CYTOTOXICITY TEST; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; RAT; WEIGHT REDUCTION;

EID: 84864183624     PISSN: None     EISSN: 09757384     Source Type: Journal    
DOI: None     Document Type: Article

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