Effects on development

Handbook of Experimental Pharmacology

Volumn 168, Issue , 2005, Pages 643-656

  Ramos, J A ^a   Gomez M ^a   De Miguel, R ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Brain development; Cannabinoid receptor; Cannabinoids; Endogenous cannabinoids; Perinatal exposure

Indexed keywords

EID: 84864160506     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/3-540-26573-2_22     Document Type: Article

References (69)

1. Araki W, Wurtman RJ (1997) Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc Natl Acad Sci USA 94:11946-11950
2. Asch RH, Smith CG (1986) Effects of Δ9-THC, the principal psychoactive component of marihuana, during pregnancy in the rhesus monkey. J Reprod Med 31:1071-1081
3. Berrendero F, García-Gil L, Hernández ML, Romero J, Cebeira R, De Miguel R, Ramos JA, Fernández-Ruiz JJ (1998) Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptors in rat brain during fetal development. Development 125:3179-3188
4. Berrendero F, Sepe N, Ramos JA, DiMarzo V, Fernández-Ruiz JJ (1999) Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period. Synapse 33:181-191
5. Biegon A, Kerman IA (2001) Autoradiographic study of pre-And postnatal distribution of cannabinoids receptors in human brain. Neuroimage 14:1463-1468
6. Bonnin A, De Miguel R, Castro JG, Ramos JA, Fernández-Ruiz JJ (1996) Effects of perinatal exposure to Δ9-Tetra Hydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase containing neurons in rat brain. J Mol Neurosci 7:291-308
7. Burden-Galley SM, Pendergast M, Lemmon V (1997) The role of cell adhesion molecule L1 in axonal extension, growth cone motility, and signal transduction. Cell Tissue Res 290:415-422
8. Corchero J, Garcia-Gil L, Manzanares J, Fernández-Ruiz JJ, Fuentes JA, Ramos JA (1998) Perinatal Δ9-Tetra Hydrocannabinol exposure reduces proenkephalin gene expression in the caudate-putamen of adult female rats. Life Sci 63:843-850
9. Dalterio SL (1980) Perinatal or adult exposure to cannabinoids alter male reproductive functions in mice. Pharmacol Biochem Behav 12:143-153
10. Dalterio SL (1986) Cannabinoid exposure: Effects on development. Neurobehav Toxicol Teratol 8:345-352
11. Dalterio SL, Barker A (1979) Perinatal exposure to cannabinoids alter male reproductive functions in mice. Science 205:1420-1422
12. Del Olmo E, Pazos A (2001) Aminergic receptors during the development of the human brain: The contribution of in vitro imaging techniques. J Chem Neuroanat 22:101-114
13. DiMarzo V (1998) Endocannabinoids and others fatty acid derivatives with cannabimimetics properties: Biochemistry and possible physiopathological relevance. Biochim Biophys Acta 1392:153-175
14. Fernández-Ruiz JJ, Rodriguez De Fonseca F, Navarro M, Ramos JA (1992)Maternal cannabinoid exposure and brain development: Changes in the ontogeny of dopaminergic neurons. In: Bartke A, Murphy LL (eds) Neurobiology and neurophysiology of cannabinoids, biochemistry and physiology of substance abuse, vol IV. CRC Press, Boca Raton, pp 119-164
15. Fernández-Ruiz JJ, Bonnin A, Cebeira M, Ramos JA (1994) Ontogenic and adult changes in the activity of hypothalamic and extrahypothalamic dopaminergic neurons after perinatal cannabinoid exposure. In: Palomo T, Archer T (eds) Strategies for studying brain disorders, vol I. Farrand Press, London, pp 357-390
16. Fernández-Ruiz JJ, Romero J, García-Gil L, Garcia-Palomero E, Ramos JA (1996) Dopaminergic neurons as neurochemical substrates of neurobehavioral effects of marihuana: Developmental and adult studies. In: Beninger RJ, Archer T, Palomo T (eds) Dopamine disease states. CYM Press, Madrid, pp 359-387
17. Fernández-Ruiz JJ, Muñoz RM, Romero J, Villanúa MA, Makriyannis A, Ramos JA (1997) Time-course of the effects of different cannabimimetics on prolactin and gonadotropin secretion: Evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. Biochem Pharmacol 53:1919-1927
18. Fernández-Ruiz JJ, Bonnin A, De Miguel R, Castro JG, Ramos JA (1998) Perinatal exposure to marihuana or its main psychoactive constituent, 9-Tetrahydrocannabinol, affects the development of brain dopaminergic neurons. Arq Med 12:67-77
19. Fernández-Ruiz JJ, Berrendero F, Hernandez ML, Romero J, Ramos JA (1999) Role of endocannabinoids in brain development. Life Sci 65:725-736
20. Fernández-Ruiz JJ, Berrendero F, Hernandez ML, Ramos JA (2000)Theendogenous cannabinoid system and brain development. Trends Neurosci 23:14-20
21. Fride E, Mechoulam R (1996a) Developmental aspects of anandamide: Ontogeny of response and prenatal exposure. Psychoneuroendocrinology 21:157-172
22. Fride E, Mechoulam R (1996b) Ontogenic development of the response to anandamide and Δ9-Tetra Hydrocannabinol in mice. Brain Res Dev Brain Res 95:131-134
23. Fride E, Ginzburg Y, Breuer A, Bisogno T, DiMarzo V, Mechoulam R(2001) Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. Eur J Pharmacol 419:207-214
24. Fried PA, Smith AM (2001) A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function. Neurotoxicol Teratol 23:1-11
25. García-Gil L, De Miguel R, Ramos JA, Fernández-Ruiz JJ (1996) Perinatal Δ9-Tetra Hydrocannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic neurons in adulthood to a variety of challenges with dopaminergic drugs. Drug Alcohol Depend 42:155-166
26. García-Gil L, Ramos JA, Rubino T, Parolaro D, Fernández- Ruiz JJ (1998) Perinatal Δ9-Tetra Hydrocannabinol exposure did not alter dopamine transporter and tyrosine hydroxylase mRNA levels in midbrain dopaminergic neurons of adult male and female rats. Neurotoxicol Teratol 20:549-553
27. García-Gil L, Romero J, Ramos JA, Fernández-Ruiz JJ (1999a) Cannabinoid receptor binding and mRNA levels in several brain regions of adult male and female rats perinatally exposed to Δ9-Tetra Hydrocannabinol. Drug Alcohol Depend 55:127-136
28. García-Gil L, De Miguel R, Romero J, Perez A, Ramos JA, Fernández-Ruiz JJ (1999b) Perinatal Δ9-Tetra Hydrocannabinol exposure augmented the magnitude of motor inhibition caused byGABA-B but notGABA-A, receptor agonists in adult rats.Neurotoxicol Teratol 21:277-283
29. Glass M, Dragunow M, Faull RLM (1997) Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77:299-318
30. Goldschmidt L, Day NL, Richardson GA (2000) Effects of prenatal marihuana exposure on child behavior problems at age 10. Neurobehav Toxicol 22:325-336
31. Gómez M, Hernández ML, Johansson B, De Miguel R, Ramos JA, Fernández-Ruiz J (2003) Prenatal cannabinoid exposure and gene expression for neural adhesionmolecule L1 in the fetal rat brain. Brain Res Dev Brain Res 147:201-207
32. González B, De Miguel R, Martin S, Perez-Rosado A, Romero J, García-Lecumberri C, Fernández-Ruiz J, Ramos JA, Ambrosio E (2003) Effects of perinatal exposure to Δ9-Tetra Hydrocannabinol on operant morphine-reinforced behavior. Pharmacol Biochem Behav 75:577-584
33. Harbison RD, Mantilla-Plata B (1972) Prenatal toxicity, maternal distribution and placental transfer of tetrahydrocannabinol. J Pharmacol Exp Ther 180:446-453
34. Herkenham M, Lynn AB, Johnson MR, Melvin LS, De Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study. J Neurosci 11:563-583
35. Hernández ML, García-Gil L, Berrendero F, Ramos JA, Fernández-Ruiz JJ (1997) Δ9-Tetra Hydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons. J Mol Neurosci 8:83-91
36. Hernández ML, Berrendero F, Suarez I, Garcia-Gil L, Cebeira M, Mackie K, Ramos JA, Fernández-Ruiz JJ (2000) Cannabinoids CB1 receptors colocalize with tyrosine hydrox ylase in cultured fetal mesencephalic neurons and their activation increases the levels of this enzyme. Brain Res 857:56-65
37. Insel TR (1995) The development of brain and behavior. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: The four generation of progress. Raven Press, New York, pp 683-694
38. Kumar AM, Haney M, Becker T, Thompson ML, Kream RM, Miczek K (1990) Effect of early exposure to Δ9-Tetra Hydrocannabinol on the levels of opioid peptides, gonadotropinreleasing hormone and substance P in the adult male rat brain. Brain Res 525:78-83
39. Mailleux P, Vanderhaeghen JJ (1992a) Location of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neurons. Neurosci Lett 148:173-176
40. Mailleux P, Vanderhaeghen JJ (1992b) Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48:655-668
41. Mato S, Del Olmo E, Pazos A (2003) Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Eur J Neurosci 17:1747-1754
42. Mereu G, FáM, Ferraro L, Cagiano R, Antonelli T, Tattoli M, Ghiglieri V, Tanganelli S, Gessa GL, Cuomo V (2003) Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-Term potentiation and glutamate release. Proc Natl Acad Sci USA 100:4915-4920
43. Mokler DA, Robinson SE, Johnson JH, Hong JS, Rosecrana JA(1987)Neonatal administration of Δ9-Tetra Hydrocannabinol alters the neurochemical response to stress in the adult Fischer-344 rat. Neurotoxicol Teratol 9:321-326
44. Molina-Holgado F, Amaro A, Gonzalez I, Alvarez FJ, Leret ML (1996) Effects ofmaternal Δ9-Tetra Hydrocannabinol ondeveloping serotoninergic neurons.Eur J Pharmacol 316:39-42
45. Molina-Holgado F, Alvarez FJ, González I, Antonio MT, Leret ML (1997)Maternal exposure to Δ9-Tetra Hydrocannabinol (Δ9-THC) alters indolamine levels and turnover in adult male and female rat brain regions. Brain Res Bull 43:173-178
46. Murphy LL, Steger RW, Bartke A (1990) Psychoactive and non-psychoactive cannabinoids and their effects on reproductive neuroendocrine parameters. In: Watson RR (ed) Biochemistry and physiology of substance abuse, vol 2. CRC Press, Boca Raton, pp 73-94
47. Murphy LL, Gher J, Szary A (1995) Effects of prenatal exposure to Δ9-Tetra Hydrocannabinol on reproductive, endocrine and immune parameters of the male and the female rat offspring. Endocrine 3:875-881
48. Navarro M, Rodríguez De Fonseca F, Hernández ML, Ramos JA, Fernández-Ruiz JJ (1994) Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids. Pharmacol Biochem Behav 47:47-58
49. Navarro M, deMiguel R, Rodríguez F, Ramos JA, Fernández JJ (1996) Perinatal cannabinoid exposuremodifies the sociosexual approachbehaviorandthemesolimbicdopaminergic activity of adult male rats. Brain Res Dev Brain Res 75:91-98
50. Pacheco MA, Ward SJ, Childers SR(1993) Identificationof cannabinoids receptors in cultures of rat cerebellar granule cells. Brain Res 603:102-110
51. Panicker AK, Bulusi M, Theleu K, Maness PF (2003) Cellular signalling mechanisms of neural cell adhesion molecules. Front Biosci 8:900-911
52. Pares-Herbute N, Tapia-Arancibia L, Artier H(1989)Ontogeny of the metencephalic, mesencephalic and diencephalic content of catecholamines as measured by high performance liquid chromatography with electrochemical detection. Int J Dev Neurosci 7:73-79
53. Park B, Gibbons HM, Mitchell MD, Glass M (2003) Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH)in the human placenta. Placenta 24:990-995
54. Park B, McPartland JM, Glass M (2004) Cannabis, cannabinoids and reproduction. Prostaglandins Leukot Essent Fatty Acids 70:189-197
55. Pérez-Rosado A, Manzanares J, Fernández-Ruiz J, Ramos JA (2000) Prenatal Δ9-Tetra Hydrocannabinol exposure modifies proenkephalin gene expression in the fetal rat brain: Sex-dependent differences. Brain Res Dev Brain Res 120:77-81
56. Pérez-Rosado A, Gomez M, Manzanares J, Ramos JA, Fernández-Ruiz J (2002) Changes in prodynorphine and POMC gene expression in several brain regions of rat fetuses prenatally exposed to Δ9-Tetra Hydrocannabinol. Neurotox Res 4:211-218
57. Ramos JA, De Miguel R, Cebeira M, Hernández ML, Fernández-Ruiz J (2002) Exposure to cannabinoids in the development of endogenous cannabinoid system. Neurotox Res 4:363-372
58. Rodriguez De Fonseca F, Cebeira M, Fernández-Ruiz JJ, Navarro M, Ramos JA (1991) Effects ofpre-And perinatal exposure to hashish extracts onthe ontogeny of brain dopaminergic neurons. Neuroscience 43:713-723
59. Romero J, García-Palomero E, Fernández-Ruiz JJ, Ramos JA (1996) Involvement of GABA-B receptors in the motor inhibition produced by agonists of brain cannabinoid receptors. Behav Pharmacol 7:299-302
60. Romero J, García-Palomero E, Berrendero F, García-Gil L, Hernández ML, Ramos JA, Fernández-Ruiz JJ (1997) Atypical location of cannabinoid receptors in white matter areas during rat brain development. Synapse 26:317-323
61. Rubio P, Rodríguez De Fonseca F, Muñoz RM, Ariznavarreta C, Martin JL, Navarro M(1995) Long-Term behavioral effects of perinatal exposure to Δ9-Tetra Hydrocannabinol in rats: Possible role of pituitary-Adrenal axis. Life Sci 56:2169-2176
62. Rubio P, Rodríguezde Fonseca F, Martin JL, del Arco I, BartoloméS, Villanúa MA, Navarro M (1998)Maternal exposure to lowdoses ofΔ9-Tetra Hydrocannabinol facilitatesmorphineinduced place conditioning in adultmale offspring. Pharmacol Biochem Behav 61:229-238
63. Rueda D, Navarro B, Martínez-Serrano A, Guzman M, Galve-Ropert I (2002) The endocannabinoid anandamide inhibits neural progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. J Biol Chem 277:46645-46650
64. Sillence DJ, AllanD (1998)Utilization of phosphatidylcholine and production of diacylglycerol as a consequence of sphingomyelin synthesis. Biochem J 331:251-256
65. Vela G, Fuentes JA, Bonnin A, Fernández-Ruiz JJ, Ruiz-Gayo M (1995) Perinatal exposure to Δ9-Tetra Hydrocannabinol (Δ9-THC) leads to changes in opioid-related behavioral patterns in rats. Brain Res 680:142-147
66. Vela G, Martin S, Garcia-Gil L, Crespo JA, Ruiz-Gayo M, Fernández-Ruiz JJ, Garcia Lecumberry C, Pelaprat D, Fuentes JA, Ramos JA, Ambrosio E (1998)Maternal exposure to Δ9-Tetra Hydrocannabinol facilitates morphine self-Administration behavior and changes regional binding to central μ-opioid receptors in adult offspring female rats. Brain Res 807:101-109
67. Walters DE, Carr LA (1988) Perinatal exposure to cannabinoids alters neurochemical development in the rat brain. Pharmacol Biochem Behav 29:213-216
68. Yang ZM, Paria BC, Dey SK (1996) Activation of brain-Type cannabinoid receptors interferes with preimplantation mouse embryo development. Biol Reprod 55:756-761
69. Zhou D, Song ZH (2001) CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells. J Neurosci Res 65:346-353