Effects of perinatal exposure to Δ9-tetrahydrocannabinol on the fetal and early postnatal development of tyrosine hydroxylase-containing neurons in rat brain

Journal of Molecular Neuroscience

Volumn 7, Issue 4, 1996, Pages 291-308

  Bonnin, Ana ^a   De Miguel, Rosario ^a   Castro, Javier G ^a   Ramos, Jose A ^a   Fernandez Ruiz, Javier J ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; NORADRENALIN; TETRAHYDROCANNABINOL; TYROSINE 3 MONOOXYGENASE;

AGING; ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; NERVE CELL; NEWBORN; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; RAT; SEXUAL DEVELOPMENT; WISTAR RAT;

3,4-DIHYDROXYPHENYLACETIC ACID; AGING; ANIMALS; ANIMALS, NEWBORN; BRAIN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; MALE; NEURONS; NOREPINEPHRINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SEX CHARACTERISTICS; TETRAHYDROCANNABINOL; TYROSINE 3-MONOOXYGENASE;

EID: 0030331414     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02737066     Document Type: Article

References (7)

1. Bonnin A., de Miguel R., Rodriguez-Manzaneque J. C., Fernandez-Ruiz J. J., Santos A., and Ramos J. A. (1994) Changes in tyrosine hydroxylase gene expression in mesencephalic catecholaminergic neurons of immature and adult male rats perinatally exposed to cannabinoids. Dev. Brain Res. 81, 147-150.
2. 9-tetrahydrocannabinol affects the gene expression and the activity of tyrosine hydroxylase during early brain development. Life Sci. 56, 2177-2184.
3. Chomczynski P. and Sacchi N. (1986) Single-step method of RNA isolation by acid guanidim'um thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
4. Coulon J. F., Faucon-Biguet N., Cavoy A., Delacour J., Mallet J., and David J. C. (1990) Gene expression of tyrosine hydroxylase in the developing fetal brain. J. Neurochem. 55, 1412-1417.
5. Fernández-Ruiz J. J., Rodriguez de Fonseca F., Navarro M., and Ramos J. A. (1992) Maternal cannabinoid exposure and brain development: changes in the ontogeny of dopaminergic neurons, in Marihuana/ Cannabinoids: Neurobiology and Neurophysiology (Murphy L. L. and Bartke A., eds.), CRC, Boca Raton, FL, pp. 119-164.
6. Fernández-Ruiz J. J., Bonnin A., Cebeira M., and Ramos J. A. (1994) Ontogenic and adult changes in the activity of hypothalamic and extrahypothalamic dopaminergic neurons after perinatal cannabinoid exposure, in Strategies for Studying Brain Disorders, vol. 1 (Palomo T. and Archer T., eds.), Farrand, London, UK, pp. 357-390.
7. 9-tetrahydrocannabinol, affects the development of brain dopaminergic neurons, in Proceedings of the International Conference on Drugs of Abuse - Recent Advances in Clinical and Experimental Research (Tavares M. A. and Ali S. F., eds.), Arquivos de Medicina, Porto, Portugal, in press.