Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: Evidence for the presence of CB 1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics

Biochemical Pharmacology

Volumn 53, Issue 12, 1997, Pages 1919-1927

  Fernández Ruiz, J Javier ^a   Muñoz, Raul M ^a   Romero, Julián ^a   Villanua, M Angeles ^a   Makriyannis, Alexandros ^b   Ramos, José A ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Anandamide; Cannabinoid receptors; Gonadotrophin; Methanandamide; Prolactin; 9 tetrahydrocannabinol

Indexed keywords

ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DRONABINOL; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; METHANANDAMIDE; PROLACTIN; RECEPTOR SUBTYPE; RIMONABANT; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; HORMONE RELEASE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INTRAPERITONEAL DRUG ADMINISTRATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROLACTIN RELEASE; RAT;

EID: 0342437524     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00168-8     Document Type: Article

References (33)

1. 9 -tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat. Neuroendocrinology 52: 316-321, 1990.
2. Murphy LL, Steger RW and Bartke A, Psychoactive and non-psychoactive cannabinoids and their effects on reproductive neuroendocrine parameters. In: Biochemistry and Physiology of Substance Abuse (Ed. Watson RR), vol. 2, pp. 73-93. CRC Press, Boca Raton, FL, 1990.
3. 9 -tetrahydrocannabinol on dopaminergic activity in several rat brain areas. Pharmacol Biochem Behav 42: 269-275, 1992.
4. Dalterio SL, Cannabinoid exposure: Effects on development. Neurobehav Toxicol Teratol 8: 345-352, 1986.
5. Rodríguez de Fonseca F, Cebeira M, Fernández-Ruiz JJ, Navarro M and Ramos JA, Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons. Neurosaence 43: 713-723, 1991.
6. Fernández-Ruiz JJ, Rodríguez de Fonseca F, Navarro M and Ramos JA, Maternal cannabinoid exposure and brain development: Changes in the ontogeny of dopaminergic neurons. In: Marihuana/Cannabinoids: Neurobiology and Neurophysiology (Eds. Murphy LL and Bartke A), pp. 119-164. CRC Press, Boca Raton, FL, 1992.
7. Romero J, García-Gil L, Ramos JA and Fernández-Ruiz JJ, The putative cannabinoid receptor ligand, anandamide, stimulates tyrosine hydroxylase activity and inhibits prolactin release. Neuroendocrine Lett 16: 159-164, 1994.
8. Wenger T, Fragakis G, Probonas K, Toth BE and Yiannakakis N, Anandamide (endogenous cannabinoid) affects anterior pituitary hormone secretion in adult male rats. Neuroendocrine Lett 16: 295-303, 1994.
9. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R, Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949, 1992.
10. 9 -Tetrahydrocannabinol suppression of prolactin secretion in the rat: Lack of direct pituitary effect. Endocrinology 109: 876-880, 1981.
11. Murphy LL, Newton SC, Dhali J and Chavez D, Evidence for a direct anterior pituitary site of Δ9-tetrahydrocannabinol action. Pharmacol Biochem Behav 40: 603-608, 1991.
12. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR and Rice KC, Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA 87: 1932-1936, 1990.
13. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR and Rice KC, Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study. J Neurosci 11: 563-583, 1991.
14. Hewlett AC, Bidaut-Russell M, Devane WA, Melvin LS, Johnson MR and Herkenham M, The cannabinoid receptor: Biochemical, anatomical and behavioral characterization. Trends Neurosci 13: 420-423, 1990.
15. Lynn AB and Herkenham M, Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J Pharmacol Exp Ther 268: 1612-1623, 1994.
16. 9 -tetrahydrocannabinol: Involvement of serotoninergic and dopaminergic pathways. Endocrinology 103: 452-458, 1978.
17. 9 -tetrahydrocannabinol: Changes in hypothalamic biogenic amines and anterior pituitary hormone secretion. Neuroendocrinol Lett 14: 349-355, 1992.
18. 9 -tetrahydrocannabinol on tuberoinfundibular dopaminergic activity, anterior pituitary sensitivity to dopamine and prolactin release vary as a function of estrous cycle. Neuroendocrinology 58: 280-286, 1993.
19. 9 -tetrahydrocannabinol-induced stimulation of tuberoinfundibular dopaminergic activity in female rats. Biochem Pharmacol 48: 1387-1392, 1994.
20. 9 -tetrahydrocannabinol on tuberoinfundibular dopaminergic activity and prolactin release in estrogen-replaced ovariectomized rats. Neuroendocrine Lett 16: 305-314, 1994.
21. Rodríguez de Fonseca F, Cebeira M, Ramos JA, Martin M and Fernández-Ruiz JJ, Cannabinoid receptors in rat brain areas: Sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci 54: 159-170, 1994.
22. Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG and Makriyannis A, (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37: 1889-1893, 1994.
23. Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martínez S, Maruani J, Neliat G, Caput D, Ferrara P, Soubrié P, Brelière JC and Le Fur G, SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350: 240-244, 1994.
24. Paxinos G and Watson C, The Rat Brain in Stereotaxic Coordinates. Academic Press, London, 1986.
25. Jansen EM, Haycock DA, Ward SJ and Seybold US, Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res 575: 93-102, 1992.
26. Esquifino AI, Marcó I and Lafuente A, Cyclosporine modifies the pulsatile secretary patterns of prolactin and luteinizing hormone in normal and pituitary-grafted female rats. Neuroendocrinology 60: 581-588, 1994.
27. Esquifino AI, Moreno ML, Agrasal C and Villanua MA, Effects of cyclosporine on ovarian function in sham-operated and pituitary-grafted young female rats. Proc Soc Exp Biol Med 208: 397-403, 1995.
28. 9 -tetrahydrocannabinol on copulatory behavior and neuroendocrine responses of male rats to female conspecifics. Pharmacol Biochem Behav 48: 1011-1017, 1994.
29. 9 -Tetrahydrocannabinol inhibits luteinizing hormone secretion in the male rat: Effect of intracerebroventricular norepinephrine infusion. Neuroendocrinol Lett 16: 1-7, 1994.
30. Mailleux P and Vanderhaeghen J-J, Distribution of neuronal cannabinoid receptors in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48: 655-668, 1992.
31. Ben-Jonathan N, Dopamine: A prolactin-inhibiting hormone. Endocr Rev 6: 564-589, 1985.
32. Tuomisto J and Männistö P, Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37: 249-342, 1985.
33. 1 -tetrahydrocannabinol on luteinizing hormone release in castrated and hypothalamic deafferented male rats. Exp Brain Res 59: 213-216, 1985.