The lipid alterations in the stratum corneum of dogs with atopic dermatitis are alleviated by topical application of a sphingolipid-containing emulsion

Clinical and Experimental Dermatology

Volumn 37, Issue 6, 2012, Pages 665-671

  Popa, I ^a   Remoue, N ^a   Osta, B ^a   Pin, D ^b   Gatto, H ^c   Haftek, M ^a   Portoukalian, J ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ DE LYON   (France)

^c Virbac SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CHOLESTEROL; FATTY ACID; GLUCOSYLCERAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; FEMALE; KERATINOCYTE; LIPID ANALYSIS; LIPID COMPOSITION; MALE; NONHUMAN; PRIORITY JOURNAL; STRATUM CORNEUM; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, TOPICAL; ANIMALS; DERMATITIS, ATOPIC; DOG DISEASES; DOGS; EMULSIONS; LIPID METABOLISM; LIPIDS; SKIN; SPHINGOLIPIDS;

EID: 84864150757     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2011.04313.x     Document Type: Article

References (30)

1. Leung DY, Boguniewicz M, Howell MD, et al. New insights in atopic dermatitis. J Clin Invest 2004; 113: 651-7.
2. Bieber T,. Atopic dermatitis. Ann Dermatol 2010; 22: 125-37.
3. Griffin CE, DeBoer DJ,. The ACVD Task Force on Canine Atopic Dermatitis (XIV): clinical manifestations of canine atopic dermatitis. Vet Immunol Immunopathol 2001; 81: 255-69.
4. Imokawa G, Abe A, Jin K, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-6.
5. Yamamoto A, Serizawa S, Ito M, Sato Y,. Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 1991; 283: 219-23.
6. Di Nardo A, Wertz PW, Giannetti A, Seidenari S,. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 1998; 78: 27-30.
7. Jungersted JM, Scheer H, Mempel M, et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010; 65: 911-18.
8. Reiter LV, Torres SM, Wertz PW,. Characterization and quantification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Vet Dermatol 2009; 20: 260-6.
9. Shimada K, Yoon JS, Yoshihara T, et al. Increased transepidermal water loss and decreased ceramide content in lesional and non-lesional skin of dogs with atopic dermatitis. Vet Dermatol 2009; 20: 541-6.
10. Macheleidt O, Kaiser HW, Sandhoff K,. Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol 2002; 119: 166-73.
11. Popa I, Thuy LH, Colsch B, et al. Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. Arch Dermatol Res 2010; 302: 639-44.
12. Popa I, Remoue N, Hoang LT, et al. Atopic dermatitis in dogs is associated with a high heterogeneity in the distribution of protein-bound lipids within the stratum corneum. Arch Dermatol Res 2011; 303: 433-40.
13. Motta S, Monti M, Sesana S,. Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1993; 1182: 147-51.
14. DeBoer DJ, Hillier A,. The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopath 2001; 81: 271-6.
15. Hillier A, DeBoer DJ,. The ACVD task force on canine atopic dermatitis (XVII): intradermal testing. Vet Immunol Immunopath 2001; 81: 289-304.
16. Piekutowska A, Pin D, Rème CA, et al. Effects of a topically applied preparation of epidermal lipids on the stratum corneum barrier of atopic dogs. J Comp Pathol 2008; 138: 197-203.
17. Wertz PW, Madison KC, Downing DT,. Covalently bound lipids of human stratum corneum. J Invest Dermatol 1989; 92: 109-11.
18. Zor T, Selinger Z,. Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal Biochem 1996; 236: 302-8.
19. Popa I, Bennaceur K, Abdul-Malak N, et al. Studies of compounds that enhance sphingolipid metabolism in human keratinocytes. Int J Cosmet Sci 2006; 28: 53-9.
20. Naoi M, Lee YC, Roseman S,. Rapid and sensitive determination of sphingosine bases and sphingolipids with fluorescamine. Anal Biochem 1974; 58: 571-7.
21. Portoukalian J, Meister R, Zwingelstein G,. Improved two-dimensional solvent system for thin-layer chromatographic analysis of polar lipids on silica gel 60 precoated plates. J Chromatogr 1978; 152: 569-74.
22. Mao-Qiang M, Brown BE, Wu-Pong S, et al. Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction. Arch Dermatol 1995; 131: 809-16.
23. Man MQ, Feingold KR, Elias PM,. Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Arch Dermatol 1993; 129: 728-38.
24. Chamlin S, Kao J, Frieden IJ, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis. changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002; 47: 198-208.
25. Na JI, Hwang JS, Park HJ, et al. A new moisturizer containing physiologic lipid granules alleviates atopic dermatitis. J Dermatol Treat 2010; 21: 23-7.
26. Holleran WM, Takagi Y, Menon GK, et al. Permeability barrier requirements regulate epidermal beta-glucocerebrosidase. J Lipid Res 1994; 35: 905-12.
27. Alessandrini F, Pfister S, Kremmer E, et al. Alterations of glucosylceramide-beta-glucosidase levels in the skin of patients with psoriasis vulgaris. J Invest Dermatol 2004; 123: 1030-6.
28. Hachem JP, Crumrine D, Fluhr J, et al. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 2003; 121: 345-53.
29. Hachem JP, Man MQ, Crumrine D, et al. Sustained serine protease activity by prolonged increase in pH leads to degradation of lipid-processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 2005; 125: 510-20.
30. Rippke F, Schreiner V, Doering T, Maibach HI,. Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus. Am J Clin Dermatol 2004; 5: 217-23.