Alterations of glucosylceramide-β-glucosidase levels in the skin of patients with psoriasis vulgaris

Journal of Investigative Dermatology

Volumn 123, Issue 6, 2004, Pages 1030-1036

  Alessandrini, Francesca ^a,b   Pfister, Sabine ^b   Kremmer, Elisabeth ^b   Gerber, Josef Karl ^b   Ring, Johannes ^a   Behrendt, Heidrun ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Epidermal lipids; Glucosylceramide glucosidase; Psoriasis vulqaris

Indexed keywords

GLUCOSYLCERAMIDASE; HYBRID PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; EPIDERMIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSORIASIS VULGARIS; PUNCH BIOPSY; SKIN BIOPSY; TISSUE LEVEL;

EID: 9744233702     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23469.x     Document Type: Article

References (51)

1. Alessandrini F, Stachowitz S, Ring J, Behrendt H: The level of prosaposin is decreased in the skin of patients with psoriasis vulgaris. J Invest Dermatol 116:394-400, 2001
2. Behne M, Uchida Y, Seki T, Ortiz de Montellano P, Elias PM, Holleran WM: Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol 114:185-192, 2000
3. Berardesca E, Fideli D, Borroni G, Rabbiosi G, Maibach H: In vivo hydration and water-retention capacity of stratum corneum in clinically uninvolved skin in atopic and psoriatic patients. Acta Derm Venereol (Stockh) 70:400-404, 1990
4. Bleck O, Abeck D, Ring J, et al: Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema. J Invest Dermatol 113:894-900, 1999
5. Bouwstra JA, Gooris GS, Dubbelaar FER, Weerheim AM, Ijzerman AP, Ponec M: Role of ceramide 1 in the molecular organization of the stratum corneum lipids. J Lipid Res 39:186-196, 1998
6. Cui CY, Kusuda S, Seguchi T, Takahashi M, Aisu K, Tezuka T: Decreased level of prosaposin in atopic skin. J Invest Dermatol 109:319-323, 1997
7. Doering T, Holleran WM, Potratz A, Vielhaber G, Elias PM, Suzuki K, Sandhoff K: Sphingolipid activator proteins are required for epidermal permeability barrier formation. J Biol Chem 274:11038-11045, 1999
8. Downing DT: Lipid and protein structures in the permeability barrier of mammalian epidermis. J Lipid Res 33:301-313, 1992
9. Elias PM: Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 80:44-49, 1983
10. Fartasch M: Epidermal barrier in disorders of the skin. Microsc Res Tech 38:361-372, 1997
11. Fukunaga K, Yoshida M, Nakajima F, et al: Design, synthesis, and evaluation of β-galactosylceramide mimics promoting β- glucocerebrosidase activity in keratinocytes. Bioorganic Med Chem Lett 13:813-815, 2003
12. Geilen CC, Wieder T, Orfanos CE: Ceramide signalling: Regulatory role in cell proliferation, differentiation and apoptosis in human epidermis. Arch Dermatol Res 289:559-566, 1997
13. Ghadially R, Reed JT, Elias PM: Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 107:558-564, 1996
14. Grubauer G, Elias PM, Feingold KR: Transepidermal water loss: The signal for recovery of barrier structure and function. J Lipid Res 30:323-333, 1989a
15. Grubauer G, Elias PM, Feingold KR, Harris RM, Elias PM: Lipid content and lipid type as determinants of the epidermal permeability barrier. J Lipid Res 30:89-96, 1989b
16. Hamanaka S, Hara M, Nishio H, Otsuka F, Suzuki A, Uchida Y: Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol 119:416-423, 2002
17. Hara M, Uchida Y, Haratake A, Mimura K, Hamanaka S: Galactocerebroside and not glucocerebroside or ceramide stimulate epidermal β- glucocerebrosicase activity. J Dermatol Sci 16:111-9, 1998
18. Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR: Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol 109:783-787, 1997
19. Holleran WM, Ginns EI, Menon GK, et al: Consequences of β-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 93:1756-1764, 1994b
20. Holleran WM, Man MQ, Goa WM, Menon GK, Elias PM, Feingold KR: Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest 88:1338-1345, 1991
21. Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elias PM: β-glucocerebrosidase activity in murine epidermis: Characterization and localization in relation to differentiation. J Lipid Res 33:1201-1209, 1992
22. Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR, Elias PM: Permeability barrier requirements regulate epidermal β- glucocerebrosidase. J Lipid Res 35:905-912, 1994a
23. Holleran WM, Takagi Y Menon GK, Legier G, Feingold KR, Elias PM: Processing of glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest 91:1656-1664, 1993
24. Jensen J-M, Schütze S, Förl M, Krönke M, Proksch E: Roles for tumor necrosis factor receptor p55 and sphingomyelinase in reparing the cutaneous permeability barrier. J Clin Invest 104:1761-1770, 1999
25. Jin K, Higaki Y, Takagi Y, Higuchi K, Yada Y, Kawashima M, Imokawa G: Analysis of beta-glucocerebrosidase and ceramidase activities in atopic and aged dry skin. Acta Derm Venereol (Stockh) 74:337-340, 1994
26. Kremmer E, Kranz BR, Hille A, et al: Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B). Virology 208:336-342, 1995
27. Lampe MA, Burlingame AL, Whitney JA, Williams ML, Brown BE, Roitman E, Elias PM: Human stratum corneum lipids: Characterization and regional variations. J Lipid Res 24:120-130, 1983a
28. Lampe MA, Williams ML, Elias PM: Human epidermal lipids: Characterization and modulations during differentiation. J Lipid Res 4:131-140, 1983b
29. Leenders F, Tesdorpf JG, Markus M, Engel T, Seedorf U, Adamski J: Porcine 80-kDa protein reveals intrinsic 17 beta-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities. J Biol Chem 271:5438-5442, 1996
30. Macheleidt O, Kaiser HW, Sandhoff K: Deficiency of epidermal protein-bound ω-hydroxyceramides in atopic dermatitis. J Invest Dermatol 119:166-173, 2002
31. Marsh NL, Elias PM, Holleran WM: Glucosylceramides stimulate murine epidermal hyperproliferation. J Clin Invest 95:2903-2909, 1995
32. Melnik BC: Disturbances of epidermal lipid metabolism and barrier function in atopic eczema. In: Ruzicka T, Ring J, Przybilla B (eds). Handbook of Atopic Eczema. Berlin: Springer-Verlag, 1991
33. Motta S, Monti M, Sesana S, Caputo R, Carelli S, Ghidoni R: Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1182:147-151, 1993
34. Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R: Abnormality of water barrier function in psoriasis. Role of ceramide fractions. Arch Dermatol 130:452-456, 1994a
35. Motta S, Sesana S, Monti M, Giuliani A, Caputo R: Interlamellar lipid differences between normal and psoriatic stratum corneum. Acta Derm Venereol (Stockh) 186 (Suppl.):131-132, 1994b
36. Murata Y, Ogata J, Higaki Y, et al: Abnormal expression of sphingomyelin acylase in atopic dermatitis: An etiologic factor for ceramide deficiency? J Invest Dermatol 106:1242-1249, 1996
37. Nickoloff BJ, Naidu Y: Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol 30:535-546, 1994
38. Ponec M, Weerheim A, Lankhorst P, Wertz P: New acylceramide in native and reconstructed epidermis. J Invest Dermatol 120:581-588, 2003
39. Proksch E, Holleran WM, Menon GK, Elias PM, Feingold KR: Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol 128:473-482, 1993
40. Robson KJ, Stewart ME, Michelsen S, Lazo ND, Downing DT: 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res 35:2060-2068, 1994
41. Schmuth M, Man MQ, Weber F, et al: Permeability barrier disorder in Niemann Pick disease: Sphingomyelin-ceramide processing required for normal barrier homeostasis. J Invest Dermatol 115:459-466, 2000
42. Serup J, Blichmann C: Epidermal hydration of psoriasis plaques and the relation to scaling. Measurement of electrical conductance and transepidermal water loss. Acta Derm Venereol (Stockh) 67:357-366, 1987
43. Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H: Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. J Invest Dermatol 119:1048-1052, 2002
44. Suzuki H, Hirano M, Baba S: Cytochemical studies of nuclear DNA and RNA in normal and abnormal keratinizing tissues. Curr Probl Dermatol 10:127-140, 1980
45. Takagi Y, Kriehuber E, Imokawa G, Elias PM, Holleran WM: β-glucocerebrosidase activity in mammalian stratum corneum. J Lipid Res 40:861-869, 1999
46. Takenouchi M, Suzuki H, Tagami H: Hydration characteristics of pathologic stratum corneum - evaluation of bound water. J Invest Dermatol 87:574-576, 1986
47. Tagami H, Yoshikuni K: Interrelationship between water-barrier and reservoir functions of pathologic stratum corneum. Arch Dermatol 121:642-645, 1985
48. Uchida Y, Hara M, Nishio H, et al: Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41:2071-2082, 2000
49. Vietzke JP, Brandt O, Abeck D, Rapp C, Strassner M, Schreiner V, Hintze U: Comparative investigation of human stratum corneum ceramides. Lipids 36:299-304, 2001
50. Wertz PW, Madison KC, Downing DT: Covalently bound lipids of human stratum corneum. J Invest Dermatol 92:109-111, 1989
51. Wertz PW, Miethke MC, Long SA, Strauss JS, Downing DT: The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 84:410-412, 1985