A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice

Journal of Leukocyte Biology

Volumn 80, Issue 4, 2006, Pages 897-904

  Kang, Liya ^a   McIntyre, Kim W ^a   Gillooly, Kathleen M ^a   Yang, Yifan ^a   Haycock, John ^b   Roberts, Stephen ^b   Khanna, Ashish ^a   Herpin, Timothy F ^a   Yu, Guixue ^a   Wu, Ximao ^a   Morton, George C ^a   Tuerdi, Huji ^a   Koplowitz, Barry ^a   Walker, Stephen G ^a   Wardwell Swanson, Judy ^a   Macor, John E ^a   Lawrence, R Michael ^a   Carlson, Kenneth E ^a,c  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

melanocyte stimulating hormone; GPCR; Inflammation; MC 1R; NF B

Indexed keywords

ANTIINFLAMMATORY AGENT; BMS 470539; CYCLIC AMP; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MELANOCORTIN 1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERANCE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE; MALE; MELANOMA CELL; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CELL MOVEMENT; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMIDAZOLES; INFLAMMATION; LEUKOCYTES; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR WEIGHT; RECEPTOR, MELANOCORTIN, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

MURINAE;

EID: 33751524332     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1204748     Document Type: Article

References (34)

1. Wikberg, J. E. S., Muceniece, R., Mandrika, I., Prusis, P., Lindblom, J., Post, C., Skottner, A. (2000) New aspects of the melanocortins and their receptors. Pharmacol. Res. 42, 393-420.
2. Catania, A., Gatti, S., Colombo, G., Lipton, J. M. (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29.
3. Cone, R. D., Lu, D., Koppula, S., Vage, D. I., Klungland, H., Boston, B., Chen, W., Orth, D. N., Pouton, C., Kesterson, R. A. (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Horm. Res. 51, 287-317.
4. Tatro, J. B. (1996) Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides. Neuroimmunomodulation 3, 259-284.
5. Cutuli, M., Cristiani, S., Lipton, J. M., Catania, A. (2000) Antimicrobial effects of α-MSH peptides. J. Leukoc. Biol. 67, 233-239.
6. Getting, S. J., Schioth, H. G., Perretti, M. (2003) Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) α-melanocyte- stimulating hormone peptides. J. Pharmacol. Exp. Ther. 306, 631-637.
7. Getting, S. J., Christian, H. C., Lam, C. W., Gavins, F. N. E., Flower, R. J., Schioth, H. B., Perretti, M. (2003) Redundancy of a funtional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J. Immunol. 170, 3323-3330.
8. Elliott, R. J., Szabo, M., Wagner, M. J., Kemp, H., MacNeil, S., Haycock, J. W. (2004) α-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signaling in human keratinocyte cells. J. Invest. Dermatol. 122, 1010-1019.[INSERT IMAGE]
9. Lipton, J. M., Catania, A., Ichiyama, T. (2000) Marshaling the anti-inflammatory influence of the neuroimmunomodulator α-MSH. News Physiol. Sci. 15, 192-195.
10. Gonindard, C., Goigoux, C., Hollande, E., D'Hinterland, L. D. (1996) The administration of an α-MSH analogue reduces the serum release of IL-1α and TNF-α induced by the injection of a sublethal dose of lipopolysaccharides in the BALB/c mouse. Pigment Cell Res. 9, 148-153.
11. Hernandez, R. D., Demitri, M. T., Carlin, A., Meazza, C., Villa, P., Lipton, J. M., Catania, A. (1999) Inhibition of systemic inflammation by central action of the neuropeptide α-melanocyte-stimulating hormone. Neuroimmunomodulation 6, 187-192.
12. Bazzani, C., Guarini, S., Botticelli, A. R., Zaffe, D., Tomasi, A., Bini, A., Cainazzo, M. M., Ferrazza, G., Mioni, C., Bertolini, A. (2001) Protective effect of melanocortin peptides in rat myocardial ischemia. J. Pharmacol. Exp. Ther. 297, 1082-1087.
13. Chiao, H., Kohda, Y., McLeroy, P., Craig, L., Housini, I., Star, R. A. (1997) α-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J. Clin. Invest. 99, 1165-1172.
14. Raap, U., Brzoska, T., Sohl, S., Path, G., Emmel, J., Herz, U., Braun, A., Luger, T., Renz, H. (2003) α-Melanocyte-stimulating hormone inhibits allergic airway inflammation. J. Immunol. 171, 353-359.
15. Gatti, S., Colombo, G., Buffa, R., Turcatti, F., Garofalo, L., Carboni, N., Ferla, L., Fassati, L., Lipton, J. M., Catania, A. (2002) α-MSH protects the allograft in experimental heart transplantation. Transplantation 74, 1678-1684.
16. Oktar, B. K., Ercan, F., Yegen, B. C., Alican, I. (2000) The effect of α-melanocyte-stimulating hormone on colonic inflammation in the rat. Peptides 21, 1271-1277.
17. Bhardwaj, R., Becher, E., Mahnke, K., Hartmeyer, M., Schwarz, T., Scholzen, T., Luger, T. A. (1997) Evidence for the differential expression of the functional α-melanocyte-stimulating hormone receptor MC-1 on human monocytes. J. Immunol. 158, 3378-3384.
18. Star, R. A., Rajora, N., Huang, J., Stock, R. E., Catania, A., Lipton, J. M. (1995) Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. USA 92, 8016-8020.
19. Bhardwaj, R. S., Schwarz, A., Becher, E., Mahnke, K., Aragane, Y., Schwarz, T., Luger, T. A. (1996) Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes. J. Immunol. 156, 2517-2521.
20. Manna, S. K., Aggarwal, B. B. (1998) α-Melanocyte-stimulating hormone inhibits the nuclear transciption factor NF-κB activation induced by various inflammatory agents. J. Immunol. 161, 2873-2880.
21. Ichiyama, T., Sakai, T., Catania, A., Barsh, G. S., Furukawa, S., Lipton, J. M. (1999) Systemically administered α-melanocyte-stimulating peptides inhibit NF-κB activation in experimental brain inflammation. Brain Res. 836, 31-37.
22. Catania, A., Rajora, N., Capsoni, F., Minonzio, F., Star, R. A., Lipton, J. M. (1996) The neuropeptide α-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 17, 675-679.
23. Ignar, D. M., Andrews, J. L., Jansen, M., Eilert, M. M., Pink, H. M., Lin, P., Sherrill, R. G., Szewczyk, J. R., Conway, J. G. (2003) Regulation of TNF-α secretion by a specific melanocortin-1 receptor peptide agonist. Peptides 24, 709-716.
24. Becher, E., Mahnke, K., Brzoska, T., Kalden, D. H., Grabbe, S., Luger, T. A. (1999) Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R. Ann. N. Y. Acad. Sci. 885, 188-195.
25. Getting, S. J., Gibbs, L., Clark, A. J., Flower, R. J., Perretti, M. (1999) POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. 162, 7446-7453.
26. Getting, S. J., Allcock, G. H., Flower, R., Perretti, M. (2001) Natural and synthetic agonists of the melanocortin type 3 receptor possess anti-inflammatory properties. J. Leukoc. Biol. 69, 98-104.
27. Herpin, T. F., Yu, G., Carlson, K. E., Morton, G. C., Wu, X., Kang, L., Tuerdi, H., Khanna, A., Tokarski, J. S., Lawrence, R. M., Macor, J. E. (2003) Discovery of tyrosine-based potent and selective melanocortin-1 receptor small molecule agonists with anti-inflammatory properties. J. Med. Chem. 46, 1123-1126.
28. Hynes Jr., J., Leftheris, K., Wu, H., Pandit, C., Chen, P., Norris, D. J., Chen, B., Zhao, R., Kiener, P., Chen, X., Turk, L., Patil-Koota, V., Gillooly, K. M., Shuster, D. J., McIntyre, K. W. (2002) C-3 amido-indole cannabinoid receptor modulators. Biorg. Med. Chem. Lett. 12, 2399-2402.
29. Cashin, C. H., Gill, J., Jones, S., Kennedy, A. (1979) An assessment of the delayed hypersenstivity reaction to methylated bovine serum albumin in the mouse and its use in the evaluation of drug effects on cell-mediated immune reactions. Agents Actions 9, 553-559.
30. Ghanem, G. E., Comunale, J., Libert, J., Vercammen, A., LeJeune, F. (1988) Evidence for α-melanocyte-stimulating hormone receptors on human malignant melanoma cells. Int. J. Cancer 41, 248-255.
31. Altavilla, D., Cainazzo, M., Squadrito, F., Guarini, S., Bertolini, A., Bazzani, C. (1998) Tumor necrosis factor-α as a target of melanocortins in haemorrhagic shock, in the anaesthetized rat. Br. J. Pharmacol. 124, 1587-1590.
32. Huang, Q., Hruby, V. J., Tatro, J. B. (1998) Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release. Am. J. Physiol. 275, R524-R530.
33. Lipton, J. M., Ceriani, G., Macaluso, A., McCoy, D., Carnes, K., Biltz, J., Catania, A. (1994) Antiinflammatory effects of the neuropeptide α-MSH in acute, chronic, and systemic inflammation. Ann. N. Y. Acad. Sci. 741, 137-148.
34. Grabbe, S., Bhardwaj, R. S., Mahnke, K., Simon, M. M., Schwarz, T., Luger, T. A. (1996) α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice. J. Immunol. 156, 473-478.