A lyophilized etoposide submicron emulsion with a high drug loading for intravenous injection: Preparation, evaluation, and pharmacokinetics in rats

Drug Development and Industrial Pharmacy

Volumn 36, Issue 12, 2010, Pages 1444-1453

  Chen, Hao ^a   Shi, Shuai ^a   Zhao, Mingming ^a   Zhang, Ling ^a   He, Haibing ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Emulsion; Etoposidephospholipid complex; Freeze drying; High drug loading; Pharmacokinetics

Indexed keywords

CRYOPROTECTIVE AGENT; ETOPOSIDE; PHOSPHOLIPID; TREHALOSE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMULSION; FREEZE DRYING; MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT; STORAGE TEMPERATURE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY DIFFRACTION; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; EMULSIONS; ETOPOSIDE; FREEZE DRYING; INJECTIONS, INTRAVENOUS; PARTICLE SIZE; PHOSPHOLIPIDS; RATS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 78149377839     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.487267     Document Type: Article

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