Design and characterization of submicron formulation for a poorly soluble drug: The effect of Vitamin e TPGS and other solubilizers on skin permeability enhancement

International Journal of Pharmaceutics

Volumn 434, Issue 1-2, 2012, Pages 90-98

  Ghosh, Indrajit ^a,b   Michniak Kohn, Bozena ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Crystal growth; Nanoparticles; Permeation rate; Porcine skin; Transdermal drug delivery; Vitamin E TPGS; Wet media milling

Indexed keywords

ALPHA TOCOPHEROL; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; POLOXAMER; POVIDONE; PROPYLENE GLYCOL; SOLUBILIZER;

ARTICLE; CRYSTAL; DRUG DESIGN; DRUG EFFECT; DRUG FORMULATION; HUMAN; INHIBITION KINETICS; PRIORITY JOURNAL; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; CRYSTALLIZATION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; IBUPROFEN; METHYLCELLULOSE; PARTICLE SIZE; PERMEABILITY; POLOXAMER; POLYETHYLENE GLYCOLS; POVIDONE; SKIN ABSORPTION; SOLUBILITY; THERMODYNAMICS; VITAMIN E;

EID: 84864123053     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.05.031     Document Type: Article

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