Estimating the contribution of genetic variants to difference in incidence of disease between population groups

European Journal of Human Genetics

Volumn 20, Issue 8, 2012, Pages 831-836

  Moonesinghe, Ramal ^a   Ioannidis, John P A ^b,c,d   Flanders, W Dana ^e   Yang, Quanhe ^f   Truman, Benedict I ^a   Khoury, Muin J ^f  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF IOANNINA   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e EMORY UNIVERSITY   (United States)

^f NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

difference in incidence; gene environmental interaction; genetic variants; population attributable risks

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INCIDENCE; PRIORITY JOURNAL;

ALGORITHMS; DIABETES MELLITUS, TYPE 2; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INCIDENCE; META-ANALYSIS AS TOPIC; MODELS, STATISTICAL; POPULATION GROUPS;

EID: 84864119668     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2012.15     Document Type: Article

References (22)

1. Richard D, Collins J: Disparities in infant mortality: what's genetics got to do with it? Am J Public Health 2007; 97: 1191-1197. (Pubitemid 351182347)
2. Drayna D: Founder mutations. Sci Am 2005; 293: 78-85. (Pubitemid 41454576)
3. Adeyomo A, Rotmi C: Genetic variations associated with complex human diseases show wide variation across multiple populations. Public Health Genomics 2010; 13: 72-79.
4. Myles S, Davison D, Barret J, Stoneking M, Timpson N: Worldwide population differentiation at disease associated SNPs. BMC Med Genomics 2008; 1: 22.
5. Chang MH, Lindegren ML, Butler MA et al: Prevalence in the United States of selected candidate gene variants: third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. Am J Epidemiol 2009; 169: 54-66.
6. Ioannidis JPA, Ntzani EE, Trikalinos TA: 'Racial' differences in genetic effects for complex diseases. Nat Genet 2004; 36: 1312-1318. (Pubitemid 39577941)
7. Ioannidis JPA, Thomas G, Daly MJ: Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 2009; 10: 318-329.
8. Ioannidis JPA: Population-wide generalizability of genome-wide discovered associations. J Natl Cancer Inst 2009; 101: 1297-1299.
9. Ntzani E, Liberopoulos G, Manolio TA, Ioannidis JP: Consistency of genome-wide associations across major ancestry groups. Hum Genet 2011; e-pub ahead of print 20 December 2011; doi:10.1007/s00439-011-1124-4.
10. Mountain JL, Risch N: Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups. Nat Genet 2004; 36: S48-S53. (Pubitemid 41103838)
11. Sankar P, Cho MK, Condit CM et al: Genetic research and health disparities. JAMA 2004; 291: 2985-2989. (Pubitemid 38802688)
12. Wray NR, Goddard ME, Visscher PM: Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res 2007; 17: 1520-1528. (Pubitemid 47529436)
13. Khoury MJ, Beaty TH, Hwang S: Detection of genotype-environment interaction in case-control studies of birth defects: how big a sample size? Teratalogy 1995; 51: 336-343.
14. Rothman K, Greenland S: Modern Epidemiology, 2nd edn. Philadelphia: Lippincott Williams & Wilkins, 1998.
15. The R Project for Statistical Computing. www.R-project.org.
16. Ng MC, Park KS, Oh B et al: Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 2008; 57: 2226-2233.
17. International HapMap Project. http://hapmap.ncbi.nlm.nih.gov.
18. McBean AM, Li S, Gilbertson DT et al: Differences in diabetes prevalence, incidence, and mortality among the elderly of four racial/ethnic groups: Whites, Blacks, Hispanics, and Asians. Diabetes Care 2004; 27: 2317-2324. (Pubitemid 39281379)
19. Fraling TM, Timpson NJ, Weedon MN et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894. (Pubitemid 46764279)
20. Scuteri A, Sanna S, Chen WM et al: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity related traits. PLoS Genet 2007; 3: e115.
21. Grant SF, Li M, Bradfield JP et al: Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 2008; 3: e1746.
22. Cheng CY, Kao WH, Patterson N et al: Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosome 5 and X. PLoS Genet 2009; 5: e1000490.