Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever

The Lancet Infectious Diseases

Volumn 12, Issue 8, 2012, Pages 635-642

  Van Paassen, Judith ^a   Bauer, Martijn P ^a   Arbous, M Sesmu ^a   Visser, Leo G ^a   Schmidt Chanasit, Jonas ^b   Schilling, Stefan ^c   Ölschläger, Stephan ^b   Rieger, Toni ^b   Emmerich, Petra ^b   Schmetz, Christel ^b   Van de Berkmortel, Franchette ^d,e   Van Hoek, Bart ^a   Van Burgel, Nathalie D ^a   Osterhaus, Albert D ^f   Vossen, Ann C T M ^a   Günther, Stephan ^b   Van Dissel, Jaap T ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d ELKERLIEK HOSPITAL   (Netherlands)

^e Sittard Geleen Heerlen   (Netherlands)

^f ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMMONIA; AMYLASE; ANTIMALARIAL AGENT; ASPARTATE AMINOTRANSFERASE; BICARBONATE; BILIRUBIN; CEFTRIAXONE; CREATINE KINASE; D DIMER; FIBRINOGEN; FRESH FROZEN PLASMA; GAMMA GLUTAMYLTRANSFERASE; GAMMA INTERFERON; GLUCOSE; HEPATITIS A VACCINE; INSULIN; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LACTIC ACID; MANNITOL; NORADRENALIN; PLACENTAL GROWTH FACTOR; SERUM ALBUMIN; TUMOR NECROSIS FACTOR ALPHA; TYPHOID VACCINE; VASCULOTROPIN RECEPTOR 1; YELLOW FEVER VACCINE;

ABDOMINAL PAIN; ACUTE LIVER FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; AMMONIA BLOOD LEVEL; AMYLASE BLOOD LEVEL; ANTIANGIOGENIC ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BAT; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING DISORDER; BRADYCARDIA; BRAIN EDEMA; CASE REPORT; CONJUNCTIVAL HEMORRHAGE; CONJUNCTIVITIS; CONTINUOUS HEMOFILTRATION; COUGHING; CREATINE KINASE BLOOD LEVEL; DEATH; DETERIORATION; DIARRHEA; DISSEMINATED INTRAVASCULAR CLOTTING; DOPPLER ECHOGRAPHY; DYSPNEA; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; ERYTHROCYTE CONCENTRATE; FEMALE; FEVER; FIBRINOGEN BLOOD LEVEL; FLUID BALANCE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEADACHE; HEARING LOSS; HEPATITIS; HEPATITIS A; HUMAN; HYPERKALEMIA; HYPERPHOSPHATEMIA; LACTATE BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; LETHARGY; LEUKOPENIA; MALARIA; MARBURG HEMORRHAGIC FEVER; MARBURG VIRUS; METABOLIC ACIDOSIS; MULTIPLE ORGAN FAILURE; MYALGIA; NAUSEA; NETHERLANDS; PAPULAR RASH; PARTIAL THROMBOPLASTIN TIME; PATHOPHYSIOLOGY; PETECHIA; PRIORITY JOURNAL; PROTHROMBIN TIME; RENAL REPLACEMENT THERAPY; RESPIRATORY FAILURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RHABDOMYOLYSIS; RIGOR; SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THERAPEUTIC HYPERVENTILATION; THORAX RADIOGRAPHY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TYPHOID FEVER; UGANDA; VIRUS LOAD; VOMITING; YELLOW FEVER;

ADULT; ANIMALS; BRAIN EDEMA; FATAL OUTCOME; FEMALE; HUMANS; INTERLEUKIN-1; LIVER FAILURE, ACUTE; MARBURG VIRUS DISEASE; MULTIPLE ORGAN FAILURE; PREGNANCY PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84864118590     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(12)70018-X     Document Type: Review

References (48)

1. Gibb TR, Norwood DA, Woollen N, Henchal EA Development and evaluation of a fluorogenic 5'-nuclease assay to identify Marburg virus. Mol Cell Probes 2001, 15:259-266.
2. Panning M, Laue T, Olschlager S, et al. Diagnostic reverse-transcription polymerase chain reaction kit for filoviruses based on the strain collections of all European biosafety level 4 laboratories. J Infect Dis 2007, 196(suppl 2):S199-S204.
3. Feldmann H Marburg hemorrhagic fever-the forgotten cousin strikes. N Engl J Med 2006, 355:866-869.
4. Martini GA, Knauff HG, Schmidt HA, Mayer G, Baltzer G [On the hitherto unknown, in monkeys originating infectious disease: Marburg virus disease]. Dtsch Med Wochenschr 1968, 93:559-571. (in German).
5. Stille W, Bohle E, Helm E, van Rey W, Siede W [On an infectious disease transmitted by Cercopithecus aethiops. (" Green monkey disease" )]. Dtsch Med Wochenschr 1968, 93:572-582. (in German).
6. Roddy P, Thomas SL, Jeffs B, et al. Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. J Infect Dis 2010, 201:1909-1918.
7. Colebunders R, Tshomba A, Van Kerkhove MD, et al. Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment. J Infect Dis 2007, 196(suppl 2):S148-S153.
8. Bausch DG, Nichol ST, Muyembe-Tamfum JJ, et al. Marburg hemorrhagic fever associated with multiple genetic lineages of virus. N Engl J Med 2006, 355:909-919.
9. Gear JS, Cassel GA, Gear AJ, et al. Outbreak of Marburg virus disease in Johannesburg. BMJ 1975, 4:489-493.
10. Smith DH, Johnson BK, Isaacson M, et al. Marburg-virus disease in Kenya. Lancet 1982, 1:816-820.
11. Johnson ED, Johnson BK, Silverstein D, et al. Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya. Arch Virol Suppl 1996, 11:101-114.
12. Bausch DG, Borchert M, Grein T, et al. Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. Emerg Infect Dis 2003, 9:1531-1537.
13. Towner JS, Amman BR, Sealy TK, et al. Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog 2009, 5:e1000536.
14. Kuzmin IV, Niezgoda M, Franka R, et al. Marburg virus in fruit bat, Kenya. Emerg Infect Dis 2010, 16:352-354.
15. Swanepoel R, Smit SB, Rollin PE, et al. Studies of reservoir hosts for Marburg virus. Emerg Infect Dis 2007, 13:1847-1851.
16. Towner JS, Pourrut X, Albarino CG, et al. Marburg virus infection detected in a common African bat. PLoS One 2007, 2:e764.
17. Emond RT, Evans B, Bowen ET, Lloyd G A case of Ebola virus infection. BMJ 1977, 2:541-544.
18. Piercy TJ, Smither SJ, Steward JA, Eastaugh L, Lever MS The survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol. J Appl Microbiol 2010, 109:1531-1539.
19. Alves DA, Glynn AR, Steele KE, et al. Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques. Vet Pathol 2010, 47:831-851.
20. Imported case of Marburg hemorrhagic fever-Colorado, 2008. MMWR Morb Mortal Wkly Rep 2009, 58:1377-1381. Anonymous.
21. Update: management of patients with suspected viral hemorrhagic fever-United States. MMWR Morb Mortal Wkly Rep 1995, 44:475-479. Centers for Disease Control and Prevention (CDC).
22. Timen A, Koopmans MP, Vossen AC, et al. Response to imported case of Marburg hemorrhagic fever, the Netherland. Emerg Infect Dis 2009, 15:1171-1175.
23. Rollin PE, Bausch DG, Sanchez A Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus. J Infect Dis 2007, 196(suppl 2):S364-S371.
24. Gedigk P, Bechtelsheimer H, Korb G [Pathological anatomy of the " Marburg virus" disease (the so-called " Marburg monkey disease" )]. Dtsch Med Wochenschr 1968, 93:590-601. (in German).
25. Geisbert TW, Jaax NK Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy. Ultrastruct Pathol 1998, 22:3-17.
26. Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 2003, 188:1618-1629.
27. Geisbert TW, Hensley LE, Jahrling PB, et al. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 2003, 362:1953-1958.
28. Bjerring PN, Eefsen M, Hansen BA, Larsen FS The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. Metab Brain Dis 2009, 24:5-14.
29. Bechtelsheimer H, Jacob H, Solcher H [On the neuropathology of the green monkey (Cercopithecus aethiops) transmitted infectious diseases in Marburg]. Dtsch Med Wochenschr 1968, 93:602-604. (in German).
30. Daddario-DiCaprio KM, Geisbert TW, Stroher U, et al. Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment. Lancet 2006, 367:1399-1404.
31. Towner JS, Khristova ML, Sealy TK, et al. Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola. J Virol 2006, 80:6497-6516.
32. Towner JS, Rollin PE, Bausch DG, et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004, 78:4330-4341.
33. Baize S, Leroy EM, Georges-Courbot MC, et al. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat Med 1999, 5:423-426.
34. Aleksandrowicz P, Wolf K, Falzarano D, Feldmann H, Seebach J, Schnittler H Viral haemorrhagic fever and vascular alterations. Hamostaseologie 2008, 28:77-84.
35. Schnittler HJ, Mahner F, Drenckhahn D, Klenk HD, Feldmann H Replication of Marburg virus in human endothelial cells. A possible mechanism for the development of viral hemorrhagic disease. J Clin Invest 1993, 91:1301-1309.
36. Wahl-Jensen VM, Afanasieva TA, Seebach J, Stroher U, Feldmann H, Schnittler HJ Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function. J Virol 2005, 79:10442-10450.
37. Feldmann H, Bugany H, Mahner F, Klenk HD, Drenckhahn D, Schnittler HJ Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages. J Virol 1996, 70:2208-2214.
38. Bockeler M, Stroher U, Seebach J, et al. Breakdown of paraendothelial barrier function during Marburg virus infection is associated with early tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1. J Infect Dis 2007, 196(suppl 2):S337-S346.
39. Stroher U, West E, Bugany H, Klenk HD, Schnittler HJ, Feldmann H Infection and activation of monocytes by Marburg and Ebola viruses. J Virol 2001, 75:11025-11033.
40. Hutchinson KL, Rollin PE Cytokine and chemokine expression in humans infected with Sudan Ebola virus. J Infect Dis 2007, 196(suppl 2):S357-S363.
41. Villinger F, Rollin PE, Brar SS, et al. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis 1999, 179(suppl 1):S188-S191.
42. Baize S, Leroy EM, Georges AJ, et al. Inflammatory responses in Ebola virus-infected patients. Clin Exp Immunol 2002, 128:163-168.
43. Fritz EA, Geisbert JB, Geisbert TW, Hensley LE, Reed DS Cellular immune response to Marburg virus infection in cynomolgus macaques. Viral Immunol 2008, 21:355-363.
44. Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use. J Cell Mol Med 2010, 14:528-552.
45. Weis SM, Cheresh DA Pathophysiological consequences of VEGF-induced vascular permeability. Nature 2005, 437:497-504.
46. Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003, 111:649-658.
47. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004, 350:672-683.
48. Larsen T, Stevens EL, Davis KJ, et al. Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus. J Infect Dis 2007, 196(suppl 2):S323-S328.