Blood chemistry measurements and D-dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus

Journal of Infectious Diseases

Volumn 196, Issue SUPPL. 2, 2007, Pages

  Rollin, Pierre E ^a   Bausch, Daniel G ^b   Sanchez, Anthony ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; AMYLASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CREATININE; D DIMER; NITROGEN; UREA; ALKALINE PHOSPHATASE; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; BLOOD ANALYSIS; BLOOD CHEMISTRY; BLOOD CLOTTING; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; EBOLA VIRUS; HEPATOBILIARY DISEASE; HOSPITAL PATIENT; HUMAN; KIDNEY DYSFUNCTION; LIVER FUNCTION TEST; LIVER INJURY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; SURVIVAL RATE; UREA NITROGEN BLOOD LEVEL; VIRUS HEMORRHAGIC FEVER; ARTICLE; BLOOD; EPIDEMIC; MORTALITY; PATHOPHYSIOLOGY; SURVIVAL; SURVIVOR; UGANDA;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; AMYLASES; ASPARTATE AMINOTRANSFERASES; BLOOD PROTEINS; DISEASE OUTBREAKS; EBOLAVIRUS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HEMORRHAGIC FEVER, EBOLA; HUMANS; SURVIVAL ANALYSIS; SURVIVORS; UGANDA;

EID: 38449083350     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/520613     Document Type: Conference Paper

References (27)

1. Sanchez A, Geisbert TW, Feldmann H. Filoviridae: Marburg and Ebola viruses. In: Knipe DM, Howley PM, Griffin DE, et al., eds. Fields virology. 5th ed. Vol 1. Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins, 2007:1409-48.
2. Baskerville A, Bowen ETW, Platt GS, McArdell LB, Simpson DLH. The pathology of experimental Ebola virus infection in monkeys. J Pathol 1978; 125:131-8.
3. Bowen ET, Platt GS, Simpson DI, McArdell LB, Raymond RT. Ebola haemorrhagic fever: experimental infection of monkeys. Trans R Soc Trop Med Hyg 1978; 72:188-91.
4. Ellis DS, Bowen ET, Simpson DI, Stamford S. Ebola virus: a comparison, at ultrastructural level, of the behaviour of the Sudan and Zaire strains in monkeys. Br J Exp Pathol 1978; 59:584-93.
5. Fisher-Hoch SP, Brammer TL, Trappier SG, et al. Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain. J Infect Dis 1992; 166:753-63.
6. Johnson E, Jaax N, White J, Jahrling P. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. Int J Exp Pathol 1995;76:227-36.
7. Gear JS, Cassel GA, Gear AJ, et al. Outbreak of Marburg virus disease in Johannesburg. Br Med J 1975; 4:489-93
8. Gedigk P, Bechtelsheimer H, Korb G. The morbid anatomy of Marburg virus disease. Ger Med Mon 1969; 14:68-77.
9. Geisbert TW, Hensley LE, Larsen T, et al. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am J Pathol 2003; 163:2347-70.
10. Murphy FA, Simpson DI, Whitfield SG, Zlotnik I, Carter GB. Marburg virus infection in monkeys: ultrastructural studies. Lab Invest 1971; 24:279-91.
11. Rippey JJ, Schepers NJ, Gear JH. The pathology of Marburg virus disease. S Afr Med J 1984; 66:50-4.
12. Zaki SR, Goldsmith CD. Pathologic features of filovirus infections in humans. Curr Top Microbiol Immunol 1999; 235:97-116.
13. Formenty P, Hatz C, Le Guenno B, et al. Human infection due to Ebola virus, subtype Côte d'Ivoire: clinical and biologic presentation. J Infect Dis 1999; 179:S48-S53.
14. Richards GA, Murphy S, Jobson R, et al. Unexpected Ebola virus in a tertiary setting: clinical and epidemiologic aspects. Crit Care Med 2000; 28:240-4.
15. Bray M, Hatfill S, Hensley L, Huggins JW. Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus. J Comp Pathol 2001; 125:243-53.
16. Hevey M, Negley D, Pushko P, Smith J, Schmaljohn A. Marburg virus vaccines based on alphavirus replicons protect guinea pig and non-human primates. Virology 1998; 251:28-37.
17. Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. Development of a preventive vaccine for Ebola virus infection in primates. Nature 2000; 408:605-9.
18. Geisbert TW, Young HA, Jahrling PB, et al. Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. Am J Pathol 2003; 163:2347-70.
19. Bick RL. Disseminated intravascular coagulation: current concepts of etiology, pathophysiology, diagnosis, and treatment. Hematol Oncol Clin North Am 2003; 17:149-76.
20. Geisbert T, Hensley L, Jahrling P, et al. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 2003; 362:1953-8.
21. Centers for Disease Control and Prevention. Outbreak of Ebola viral hemorrhagic fever - Uganda, August 2000-January 2001. MMWR Morb Mortal Wkly Rep 2001; 50:73-7.
22. Sanchez A, Lukwiya M, Bausch D, et al. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol 2004; 78:10370-7.
23. Towner JS, Rollin PE, Bausch DG, et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004; 78:4330-41.
24. Bausch DG, Towner JS, Dowell SF, et al. Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis 2007; 196(Suppl 2):S142-7 (in this supplement).
25. Bray M, Mahanty S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003; 188:1613-7.
26. Geisbert TW, Young HA. Jahrling PB, et al. Mechanisms underlying coagulation abnormalities in Ebola hemorrhagic fever: overexpresssion of tissue factor in primate monocytes/macrophages is a key event. J Infect Dis 2003; 188:1618-29.
27. Saba HI, Morelli GA. The pathogenesis and management of disseminated intravascular coagulation. Clin Adv Hematol Oncol 2006; 4:919-26.