Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 57-71

  Criswell, Kay A ^a   Cook, Jon C ^a   Wojcinski, Zbigniew ^b   Pegg, David ^c   Herman, James ^d   Wesche, David ^d   Giddings, John ^e   Brady, Joseph T ^a   Anderson, Timothy ^a  

^a PFIZER INC   (United States)

^b Drug Development Preclinical Services LLC   (United States)

^c Michigan Technology and Research Institute   (United States)

^d Integrated Nonclinical Development Solutions   (United States)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

2 subunit; Clinical trials.; Hemangiosarcoma; Human relevance; Mice; Mode of action; Pregabalin

Indexed keywords

BIOLOGICAL MARKER; LIPOCORTIN 5; PLACEBO; PREGABALIN; THROMBOMODULIN; TUMOR MARKER;

ANGIOSARCOMA; ARTICLE; BICARBONATE BLOOD LEVEL; CANCER INCIDENCE; CANCER RISK; CLINICAL ASSESSMENT; CLINICAL TRIAL (TOPIC); CONCEPTUAL FRAMEWORK; DISEASE ASSOCIATION; DISORDERS OF ACID BASE BALANCE; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HYPOXEMIA; LEUKOCYTE COUNT; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PUBLICATION; THROMBOCYTE FUNCTION;

ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HEMANGIOSARCOMA; HUMANS; MACROPHAGE ACTIVATION; MICE;

MUS; RATTUS;

EID: 84864118559     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs149     Document Type: Article

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