Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) Receptor by tissue plasminogen activator: Identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor

Journal of Biological Chemistry

Volumn 287, Issue 30, 2012, Pages 25520-25529

  Ng, Kay Siong ^a   Leung, How Wing ^a   Wong, Peter T H ^a   Low, Chian Ming ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE ISCHEMIC STROKE; AMINO TERMINUS; AMINO-TERMINAL DOMAIN; CLEAVAGE SITES; CORTICAL NEURONS; FUSION PROTEINS; HETEROLOGOUS EXPRESSION; LYSATES; N-METHYL-D-ASPARTATE; NEURODEGENERATION; NMDA RECEPTOR; PATHOPHYSIOLOGICAL; PEPTIDE SEQUENCING; PHARMACOLOGICAL PROPERTIES; RAT BRAIN; SITE DIRECTED MUTAGENESIS; SYNAPTIC PLASTICITY; THROMBOLYSIS; TIME-DEPENDENT; TISSUE PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR (TPA);

BRAIN; DEGRADATION; PATIENT TREATMENT; RECOMBINANT PROTEINS; TISSUE;

AMINO ACIDS;

ALANINE; ALTEPLASE; ARGININE; GLUTAMINE; GLYCINE; HYBRID PROTEIN; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PEPTIDE; PLASMIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL LYSATE; CONTROLLED STUDY; DRUG MECHANISM; MALE; NERVE CELL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; GLYCINE AGENTS; HUMANS; MALE; MUTAGENESIS, SITE-DIRECTED; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

RATTUS;

EID: 84864095373     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.374397     Document Type: Article

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