Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 3, 2008, Pages 506-515

  Fujimoto, Shinji ^a   Katsuki, Hiroshi ^a,b   Ohnishi, Masatoshi ^a   Takagi, Mikako ^a   Kume, Toshiaki ^a   Akaike, Akinori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Collagenase; Cortical cells; Hemorrhagic brain injury; Plasminogen; Slice cultures; Thrombin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APROTININ; ARGATROBAN; CLODRONIC ACID; COLLAGENASE; CYCLOHEXIMIDE; MITOGEN ACTIVATED PROTEIN KINASE; PLASMIN; PLASMINOGEN; THROMBIN; TRANEXAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN HEMORRHAGE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; MALE; MICROINJECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; CELL DEATH; CEREBRAL CORTEX; CEREBRAL HEMORRHAGE; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; NEURONS; PHOSPHORYLATION; PLASMINOGEN; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; THROMBIN;

EID: 39749141492     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600547     Document Type: Article

References (36)

1. Brambilla R, Neary JT, Cattabeni F, Cottini L, D'Ippolito G, Schiller PC, Abbracchio MP (2002) Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. J Neurochem 83:1285-96
2. Castellino FJ, Ploplis VA (2005) Structure and function of the plasminogen/plasmin system. Thromb Haemost 93:647-54
3. Chang WC, Shi GY, Chow YH, Chang LC, Hau JS, Lin MT, Jen CJ,Wing LY,Wu HL (1993) Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells. Am J Physiol 264:C271-81
4. Chen ZL, Strickland S (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91:917-25
5. Donovan FM, Pike CJ, Cotman CW, Cunningham DD (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 17:5316-26
6. Ellis V, Behrendt N, Danø K (1991) Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266:12752-8
7. Engles L (2005) Review and application of serine protease inhibition in coronary artery bypass graft surgery. Am J Health Syst Pharm 62(Suppl 4):S9-14
8. Fujimoto S, Katsuki H, Kume T, Akaike A (2006) Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures. Neurobiol Dis 22:130-42
9. Fujimoto S, Katsuki H, Ohnishi M, Takagi M, Kume T, Akaike A (2007) Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. Neuroscience 144:694-701
10. Hajjar KA, Harpel PC, Jaffe EA, Nachman RL (1986) Binding of plasminogen to cultured human endothelial cells. J Biol Chem 261:11656-62
11. Hu S, Peterson PK, Chao CC (1997) Cytokine-mediated neuronal apoptosis. Neurochem Int 30:427-31
12. Lee KR, Colon GP, Betz AL, Keep RF, Kim S, Hoff JT (1996) Edema from intracerebral hemorrhage: the role of thrombin. J Neurosurg 84:91-6
13. Mahdy AM, Webster NR (2004) Perioperative systemic haemostatic agents. Br J Anaesth 93:842-58
14. Mandell JW, VandenBerg SR (1999) ERK/MAP kinase is chronically activated in human reactive astrocytes. NeuroReport 10:3567-72
15. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2005) Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352:777-85
16. Mayer SA, Rincon F (2005) Treatment of intracerebral haemorrhage. Lancet Neurol 4:662-72
17. Miles LA, Hawley SB, Baik N, Andronicos NM, Castellino FJ, Parmer RJ (2005) Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci 10:1754-62
18. Nakajima K, Hamanoue M, Takemoto N, Hattori T, Kato K, Kohsaka S (1994) Plasminogen binds specifically to α-enolase on rat neuronal plasma membrane. J Neurochem 63:2048-57
19. O'Brien JG, Battistini B, Zaharia F, Plante GE, Sirois P (2000) Effects of tranexamic acid and aprotinin, two antifibrinolytic drugs, on PAF-induced plasma extravasation in unanesthetized rats. Inflammation 24: 411-29
20. Ohnishi M, Katsuki H, Fujimoto S, Takagi M, Kume T, Akaike A (2007) Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Exp Neurol 206:43-52
21. Patthy L (1985) Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules. Cell 41:657-63
22. Pekny M, Nilsson M (2005) Astrocyte activation and reactive gliosis. Glia 50:427-34
23. Plow EF, Herren T, Redlitz A, Miles LA, Hoover-Plow JL (1995) The cell biology of the plasminogen system. FASEB J 9:939-45
24. Prentice CR (1980) Basis of antifibrinolytic therapy. J Clin Pathol Suppl (R Coll Pathol) 14:35-40
25. Robbins KC, Summaria L, Hsieh B, Shah RJ (1967) The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin. J Biol Chem 242:2333-42
26. Schneider M, Nesheim M (2004) A study of the protection of plasmin from antiplasmin inhibition within an intact fibrin clot during the course of clot lysis. J Biol Chem 279:13333-9
27. Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T (2006) Roles of glia-derived cytokines on neuronal degeneration and regeneration. Ann N Y Acad Sci 1088:219-29
28. Syrovets T, Tippler B, Rieks M, Simmet T (1997) Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. Blood 89:4574-83
29. Takahashi H, Nagai N, Urano T (2005) Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia. Neurosci Lett 381:189-93
30. Tsirka SE, Bugge TH, Degen JL, Strickland S (1997a) Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin. Proc Natl Acad Sci USA 94:9779-81
31. Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S (1997b) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 17:543-52
32. Wu HL, Chang BI, Wu DH, Chang LC, Gong CC, Lou KL, Shi GY (1990) Interaction of plasminogen and fibrin in plasminogen activation. J Biol Chem 265:19658-64
33. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63
34. Xue M, Del Bigio MR (2001) Acute tissue damage after injections of thrombin and plasmin into rat striatum. Stroke 32:2164-9
35. Xue M, Del Bigio MR (2005) Injections of blood, thrombin, and plasminogen more severely damage neonatal mouse brain than mature mouse brain. Brain Pathol 15:273-80
36. Xue M, Hollenberg MD, Yong VW (2006) Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice. J Neurosci 26:10281-91