Transforming growth factor-beta inhibits the expression of clock genes

Annals of the New York Academy of Sciences

Volumn 1261, Issue 1, 2012, Pages 79-87

  Gast, Heidemarie ^a   Gordic, Sonja ^b   Petrzilka, Saskia ^b   Lopez, Martin ^b   Müller, Andreas ^b   Gietl, Anton ^b   Hock, Christoph ^b   Birchler, Thomas ^b   Fontana, Adriano ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

E box; Memory; Sleep deprivation; Sleep genes

Indexed keywords

NUCLEAR RECEPTOR NR1D1; PER1 PROTEIN; PER2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONTROLLED STUDY; D SITE ALBUMIN PROMOTER BINDING GENE; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MOUSE; NERVE CELL; NERVE TRACT; NONHUMAN; PROTEIN CEREBROSPINAL FLUID LEVEL; SLEEP WAKING CYCLE; THYROTROPH EMBRYONIC FACTOR GENE;

EID: 84864087730     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06640.x     Document Type: Article

References (37)

1. Lesne, S., F. Docagne, C. Gabriel, et al. 2003. Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J. Biol. Chem. 278: 18408-18418.
2. Wyss-Coray, T., C. Lin, F. Yan, et al. 2001. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 7: 612-628.
3. Wyss-Coray, T., E. Masliah, M. Mallory, et al. 1997. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 389: 603-606.
4. Town, T., Y. Laouar, C. Pittenger, et al. 2008. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat. Med. 14: 681-687.
5. Hashimoto, Y., T. Chiba, M. Yamada, et al. 2005. Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol. Cell Biol. 25: 9304-9317.
6. Hashimoto, Y., M. Nawa, T. Chiba, et al. 2006. Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta. J. Neurosci. Res. 83: 1039-1047.
7. Noguchi, A., M. Nawa, S. Aiso, et al. 2010. Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int. J. Neurosci. 120: 168-175.
8. Lee, H.G., M. Ueda, X. Zhu, et al. 2006. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway? J. Neurosci. Res. 84: 1856-1861.
9. Beynon, A.L., A.N. Coogan & J. Thome. 2009. Age and time of day influences on the expression of transforming growth factor-beta and phosphorylated SMAD3 in the mouse suprachiasmatic and paraventricular nuclei. Neuroimmunomodulation 16: 392-399.
10. Swardfager, W., K. Lanctot, L. Rothenburg, et al. 2010. A meta-analysis of cytokines in Alzheimer's disease. Biol. Psychiatr. 68: 930-941.
11. Vawter, M.P., O. Dillon-Carter, W.W. Tourtellotte, et al. 1996. TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid. Exp. Neurol. 142: 313-322.
12. Depino, A.M., L. Lucchina & F. Pitossi. 2011. Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior. Brain Behav. Immun. 25:1582-1591.
13. Morris, J.C. 1996. Classification of dementia and Alzheimer's disease. Acta. Neurol. Scand. Suppl. 165: 41-50.
14. Nadel, L. & M. Moscovitch. 1997. Memory consolidation, retrograde amnesia and the hippocampal complex. Curr. Opin. Neurobiol. 7: 217-227.
15. Squire, L.R. & P. Alvarez. 1995. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr. Opin. Neurobiol. 5: 169-177.
16. Rauchs, G., B. Desgranges, J. Foret & F. Eustache. 2005. The relationships between memory systems and sleep stages. J. Sleep Res. 14: 123-140.
17. Rauchs, G., M. Schabus, S. Parapatics, et al. 2008. Is there a link between sleep changes and memory in Alzheimer's disease? Neuroreport 19: 1159-1162.
18. Westerberg, C.E., E.M. Lundgren, S.M. Florczak, et al. 2010. Sleep influences the severity of memory disruption in amnestic mild cognitive impairment: results from sleep self-assessment and continuous activity monitoring. Alzheimer Dis. Assoc. Disord. 24: 325-333.
19. Weldemichael, D.A. & G.T. Grossberg. 2010. Circadian rhythm disturbances in patients with Alzheimer's disease: a review. Int. J. Alzheimers Dis. 1-9.
20. Hastings, M.H. 2003. Circadian clocks: self-assembling oscillators? Curr. Biol. 13: R681-R682.
21. Schibler, U. 2009. The 2008 Pittendrigh/Aschoff lecture: peripheral phase coordination in the mammalian circadian timing system. J. Biol. Rhythms 24: 3-15.
22. McKhann, G., D. Drachman, M. Folstein, et al. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
23. Petersen, R.C., G.E. Smith, S.C. Waring, et al. 1999. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 56: 303-308.
24. Petrzilka, S., C. Taraborrelli, G. Cavadini, et al. 2009. Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling. J. Biol. Rhythms 24: 283-294.
25. Nagoshi, E., C. Saini, C. Bauer, et al. 2004. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119: 693-705.
26. Ito, Y. & K. Miyazono. 2003. RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr. Opin. Genet Dev. 13: 43-47.
27. Kon, N., T. Hirota, T. Kawamoto, et al. 2008. Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nat. Cell Biol. 10: 1463-1469.
28. Zawel, L., J. Yu, C.J. Torrance, et al. 2002. Dec1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Proc. Natl. Acad. Sci. U.S.A. 99: 2848-2853.
29. Honma, S., T. Kawamoto, Y. Takagi, et al. 2002. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419: 841-844.
30. Rota, E., G. Bellone, P. Rocca, et al. 2006. Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol. Sci. 27: 33-39.
31. Tarkowski, E. 2002. Cytokines in dementias. Curr. Drug Targets Inflamm. Allergy 1: 193-200.
32. Lebert, F., F. Pasquier & H. Petit. 1996. Sundowning syndrome in demented patients without neuroleptic therapy. Arch. Gerontol. Geriatr. 22: 49-54.
33. Wu, Y.H., D.F. Fischer, A. Kalsbeek, et al. 2006. Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock." FASEB J. 20: 1874-1876.
34. Taraborrelli, C., S. Palchykova, I. Tobler, et al. 2011. TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation. Brain Behav. Immun. 25: 434-442.
35. Eger, A., K. Aigner, S. Sonderegger, et al. 2005. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24: 2375-2385.
36. Borbely, A. 1982. Endogenous sleep-promoting substances. Trends Pharmacol. Sci. 3: 350.
37. Franken, P., D. Chollet & M. Tafti. 2001. The homeostatic regulation of sleep need is under genetic control. J. Neurosci. 21: 2610-2621.