Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 87, Issue 1, 2012, Pages 25-33

  Reardon, Holly T ^a   Zhang, Jimmy ^a   Kothapalli, Kumar S D ^a   Kim, Andrea J ^a   Jung Park, Woo ^a   Thomas Brenna, J ^a  

^a Cornell University ^*  (United States)

Author keywords

FADS1; FADS2; Insertion deletion; Intron; LCPUFA; LXR; SREBP 1c; Statin

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; ACYL COENZYME A DESATURASE 2; ROSIGLITAZONE; SIMVASTATIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RESPONSE; ENZYME ACTIVITY; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENETIC CONSERVATION; GENETIC VARIABILITY; HAPLOTYPE; HAPLOTYPE MAP; HETEROZYGOTE DETECTION; HOMOZYGOSITY; HUMAN; HUMAN CELL; INTRON; JAPANESE; LYMPHOBLAST; MICROARRAY ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION;

BASE SEQUENCE; BENZOATES; BENZYLAMINES; BINDING SITES; CELLS, CULTURED; CONSERVED SEQUENCE; FATTY ACID DESATURASES; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FREQUENCY; HAPLOTYPES; HETEROZYGOTE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDEL MUTATION; INTRONS; LINKAGE DISEQUILIBRIUM; LOCUS CONTROL REGION; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORPHAN NUCLEAR RECEPTORS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RESPONSE ELEMENTS; SEQUENCE ANALYSIS, DNA; SIMVASTATIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THIAZOLIDINEDIONES;

EID: 84864081781     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2012.04.011     Document Type: Article

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