Endoplasmic Reticulum Stress in Maternal Diabetes-Induced Cardiac Malformations During Critical Cardiogenesis Period

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 95, Issue 1, 2012, Pages 1-6

  Zhao, Zhiyong ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Atrioventricular septal defects; Cardiac defects; Cell migration; Chaperone; Diabetic embryopathy; Endocardial cushion; Endoplasmic reticulum stress

Indexed keywords

4 PHENYLBUTYRIC ACID; GLUCOSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; ENDOCARDIUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HISTOLOGY; HYPERGLYCEMIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MATERNAL DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TISSUE DISTRIBUTION;

ATRIOVENTRICULAR SEPTAL DEFECTS; CARDIAC DEFECTS; CELL MIGRATION; CHAPERONE; DIABETIC EMBRYOPATHY; ENDOCARDIAL CUSHION; ENDOPLASMIC RETICULUM STRESS;

ANIMALS; CELL MOVEMENT; DIABETES, GESTATIONAL; DISEASE SUSCEPTIBILITY; EMBRYO, MAMMALIAN; ENDOCARDIUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HEART SEPTAL DEFECTS; HYPERGLYCEMIA; MICE; MICE, INBRED C57BL; ORGANOGENESIS; PREGNANCY;

MUS;

EID: 84864066895     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20330     Document Type: Article

References (38)

1. Anderson RH, Webb S, Brown NA, et al. 2003. Development of the heart: (2) Septation of the atriums and ventricles. Heart 89:949-958.
2. Brown CB, Boyer AS, Runyan RB, Barnett JV. 1999. Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. Science 283:2080-2082.
3. Budzyn K, Marley PD, Sobey CG. 2006. Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol Sci 27:97-104.
4. Correa A, Gilboa SM, Besser LM, et al. 2008. Diabetes mellitus and birth defects. Am J Obstet Gynecol 199:e231-e239.
5. Enciso JM, Gratzinger D, Camenisch TD, et al. 2003. Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. J Cell Biol 160:605-615.
6. Ferencz C, Rubin JD, McCarter RJ, Clark EB. 1990. Maternal diabetes and cardiovascular malformations: predominance of double outlet right ventricle and truncus arteriosus. Teratology 41:319-326.
7. Fisher SA, Langille BL, Srivastava D. 2000. Apoptosis during cardiovascular development. Circ Res 87:856-864.
8. Hosoi T, Ozawa K. 2010. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities. Clin Sci 118:19-29.
9. Jawerbaum A, Gonzalez E. 2005. The role of alterations in arachidonic acid metabolism and nitric oxide homeostasis in rat models of diabetes during early pregnancy. Curr Pharm Des 11:1327-1342.
10. Jawerbaum A, Higa R, White V, et al. 2005. Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. Reproduction 130:695-703.
11. Kim JS, Viragh S, Moorman AF, et al. 2001. Development of the myocardium of the atrioventricular canal and the vestibular spine in the human heart. Circ Res 88:395-402.
12. Kumar SD, Dheen ST, Tay SS. 2007. Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development. Cardiovasc Diabetol 6:34.
13. Kumar SD, Yong S-K, Dheen ST, et al. 2008. Cardiac malformations are associated with altered expression of vascular endothelial growth factor and endothelial nitric oxide synthase genes in embryos of diabetic mice. Exp Biol Med 233:1421-1432.
14. Lamers WH, Moorman AF. 2002. Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis. Circ Res 91:93-103.
15. Lin JH, Walter P, Yen TS. 2008. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol 3:399-425.
16. Loeken MR. 2004. Free radicals and birth defects. J Matern Fetal Neonatal Med 15:6-14.
17. Maattanen P, Gehring K, Bergeron JJ, Thomas DY. 2010. Protein quality control in the ER: the recognition of misfolded proteins. Semin Cell Dev Biol 21:500-511.
18. Markwald RR, Fitzharris TP, Manasek FJ. 1977. Structural development of endocardial cushions. Am J Anat 148:85-119.
19. Mills JL. 1982. Malformations in infants of diabetic mothers. Teratology 25:385-394.
20. Mills JL, Baker L, Goldman AS. 1979. Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment. Diabetes 28:292-293.
21. Minamino T, Kitakaze M. 2010. ER stress in cardiovascular disease. J Mol Cell Cardiol 48:1105-1110.
22. Ozcan U, Yilmaz E, Ozcan L, et al. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140.
23. Person AD, Klewer SE, Runyan RB. 2005. Cell biology of cardiac cushion development. Int Rev Cytol 243:287-335.
24. Poelmann RE, Gittenberger-de Groot AC. 2005. Apoptosis as an instrument in cardiovascular development. Birth Defects Res C Embryo Today 75:305-313.
25. Reece EA, Homko CJ. 2000. Why do diabetic women deliver malformed infants? Clin Obstet Gynecol 43:32-45.
26. Sakabe M, Ikeda K, Nakatani K, et al. 2006. Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation. Dev Dyn 235:94-104.
27. Sakabe M, Sakata H, Matsui H, et al. 2008. ROCK1 expression is regulated by TGFβ3 and ALK2 during valvuloseptal endocardial cushion formation. Anat Rec 291:845-857.
28. Thomas SE, Dalton LE, Daly ML, et al. 2010. Diabetes as a disease of endoplasmic reticulum stress. Diabetes Metab Res Rev 26:611-621.
29. Tsuchida K, Sunada Y, Noji S, et al. 2006. Inhibitors of the TGFβ superfamily and their clinical applications. Mini Rev Med Chem 6:1255-1261.
30. Vuillemin M, Pexieder T. 1989. Normal stages of cardiac organogenesis in the mouse: I. Development of the external shape of the heart. Am J Anat 184:101-113.
31. Webb S, Brown NA, Anderson RH. 1998. Formation of the atrioventricular septal structures in the normal mouse. Cir Res 82:645-656.
32. Wren C, Birrell G, Hawthorne G. 2003. Cardiovascular malformations in infants of diabetic mothers. Heart 89:1217-1220.
33. Yamagishi T, Ando K, Nakamura H. 2009. Roles of TGFβ and BMP during valvulo-septal endocardial cushion formation. Anat Sci Int 84:77-87.
34. Yang P, Zhao Z, Reece EA. 2008. Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy. Am J Obstet Gynecol 198:e131-e137.
35. Zhao Z. 2010. Cardiac malformations and alteration of TGFβ signaling system in diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol 89:97-105.
36. Zhao Z, Reece EA. 2005. Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions. J Soc Gynecol Investig 12:549-557.
37. Zhao Z, Rivkees SA. 2000. Programmed cell death in the developing heart: regulation by BMP4 and FGF2. Dev Dyn 217:388-400.
38. Zhao Z, Rivkees SA. 2004. Rho-associated kinases play a role in endocardial cell differentiation and migration. Dev Biol 275:183-191.