Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections

Electronic Journal of Biotechnology

Volumn 15, Issue 4, 2012, Pages

  Vilos, Cristian ^a,b,c   Constandil, Luis ^a,b,c   Herrera, Natalia ^a   Solar, Paula ^a   Escobar Fica, Jorge ^d   Velásquez, Luis Alberto ^a,c  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^c CENTER FOR THE DEVELOPMENT OF NANOSCIENCE AND NANOTECHNOLOGY CEDENNA   (Chile)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

Author keywords

Ceftiofur; Drug delivery; Livestock breeding industry; PHBV; Polymeric microparticles

Indexed keywords

ANIMAL HEALTH; ANTI-BACTERIAL ACTIVITY; CEFTIOFUR; ECONOMIC LOSS; ENCAPSULATION EFFICIENCY; INFECTIOUS DISEASE; LIVESTOCK BREEDING; MICRO-PARTICLES; PHBV; POTENTIAL APPLICATIONS; POTENTIAL FORMULATIONS; SMOOTH SURFACE; SPHERICAL SHAPE; SUSTAINED RELEASE;

ANTIBIOTICS; DRUG DELIVERY; DRUG DOSAGE; ENCAPSULATION; LOSSES; POLYMERS; VETERINARY MEDICINE;

AGRICULTURE;

3 (HYDROXUBUTYRATE CO 3 HYDROXYVALERATE); CEFTIOFUR; POLYMER; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; ESCHERICHIA COLI; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ZETA POTENTIAL;

ANIMALIA;

EID: 84864051756     PISSN: None     EISSN: 07173458     Source Type: Journal    
DOI: 10.2225/vol15-issue4-fulltext-2     Document Type: Article

References (34)

1. AHMED, I. and KASRAIAN, K. (2002). Pharmaceutical challenges in veterinary product development. Advanced Drug Delivery Reviews, vol. 54, no. 6, p. 871-882. [CrossRef]
2. ATKINS, T.W.; PEACOCK, S.J. and YATES, D.J. (1998). Incorporation and release of vancomycin from poly(D, L-lactide-co-glycolide) microspheres. Journal of Microencapsulation, vol. 15, no. 1, p. 31-44. [CrossRef]
3. BARTON, M.D. (2000). Antibiotic use in animal feed and its impact on human healt. Nutrition Research Reviews, vol. 13, no. 2, p. 279-299.
4. BATYCKY, R.P.; HANES, J.; LANGER, R. and EDWARDS, D.A. (1997). A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. Journal of Pharmaceutical Sciences, vol. 86, no. 12, p. 1464-1477. [CrossRef]
5. BLANCO-PRÍETO, M.; LECAROZ, C.; RENEDO, M.J.; KUNKOVA, J. and GAMAZO, C. (2002). In vitro evaluation of gentamicin released from microparticles. International Journal of Pharmaceutics, vol. 242, no. 1-2, p. 203-206. [CrossRef]
6. BROWN, S.A.; HANSON, B.J.; MIGNOT, A.; MILLÉRIOUX, L.; HAMLOW, P.J.; HUBBARD, V.L.; CALLAHAN, J.K. and KAUSCHE, F.M. (1999). Comparison of plasma pharmacokinetics and bioavailability of ceftiofur sodium and ceftiofur hydrochloride in pigs after a single intramuscular injection. Journal of Veterinary Pharmacology and Therapeutics, vol. 22, no. 1, p. 35-40. [CrossRef]
7. CHEN, J. and DAVIS, S.S. (2002). The release of diazepam from poly(hydroxybutyrate-hydroxyvalerate) microspheres. Journal of Microencapsulation, vol. 19, no. 2, p. 191-201. [CrossRef]
8. COIMBRA, P.A.; DE SOUSA, H.C. and GIL, M.H. (2008). Preparation and characterization of flurbiprofen-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres. Journal of Microencapsulation, vol. 25, no. 3, p. 170-178. [CrossRef]
9. DEMAIN, A.L. and SANCHEZ, S. (2009). Microbial drug discovery: 80 years of progress. The Journal of Antibiotics, vol. 62, no. 1, p. 5-16. [CrossRef]
10. DURAN, N.; ALVARENGA, M.A.; DA SILVA, E.C.; MELO, P.S. and MARCATO, P.D. (2008). Microencapsulation of antibiotic rifampicin in poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Archives of Pharmacal Research, vol. 31, no. 11, p. 1509-1516. [CrossRef]
11. EDLUND, U. and ALBERTSSON, C. (2002). Degradable polymer microspheres for controlled drug delivery. Advances in Polymer Science, vol. 157, p. 67-112. [CrossRef]
12. FARAGO, P.V.; RAFFIN, R.P.; POHLMANN, A.R.; GUTERRES, S.S. and ZAWADZKI, S.F. (2008). Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique. Journal of the Brazilian Chemical Society, vol. 19, no. 7, p. 1298-1305. [CrossRef]
13. GÖPFERICH, A. (1996). Mechanisms of polymer degradation and erosion. Biomaterials, vol. 17, no. 2, p. 103-114. [CrossRef]
14. HIBBARD, B.; ROBB, E.J.; CHESTER, S.T. Jr.; DAME, K.J.; MOSELEY, W.W. and BRYSON, W.L. (2002). Dose determination and confirmation for ceftiofur crystalline-free acid administered in the posterior aspect of the ear for control and treatment of bovine respiratory disease. Veterinary Therapeutics, vol. 3, no. 1, p. 22-30.
15. HORNISH, R.E. and KOTARSKI, S.F. (2002). Cephalosporins in veterinary medicine-ceftiofur use in food animals. Current Topics in Medicinal Chemistry, vol. 2, no. 7, p. 717-731.
16. HUANG, W.; SHI, X.; REN, L.; DU, C. and WANG, C.Y. (2010). PHBV microspheres-PLGA matrix composite scaffold for bone tissue engineering. Biomaterials, vol. 31, no. 15, p. 4278-4285. [CrossRef]
17. KNEZEVIC, P. and PETROVIC, O. (2008). Antibiotic resistance of commensal Escherichia coli of food-producing animals from three Vojvodinian farms, Serbia. International Journal of Antimicrobial Agents, vol. 31, no. 4, p. 360-363. [CrossRef]
18. LAMPRECHT, A.; SCHÄFER, U. and LEHR, C.M. (2000). Structural analysis of microparticles by confocal laser scanning microscopy. AAPS PharmSciTech, vol. 1, no. 3, p. 10-19. [CrossRef]
19. LAO, L.L.; PEPPAS, N.A.; BOEY, F.Y.C. and VENKATRAMAN, S.S. (2011). Modeling of drug release from bulk-degrading polymers. International Journal of Pharmaceutics, vol. 418, no. 1, p. 28-41. [CrossRef]
20. LI, H. and CHANG, J. (2005). Preparation, characterization and in vitro release of gentamicin from PHBV/wollastonite composite microspheres. Journal of Controlled Release, vol. 107, no. 3, p. 463-473. [CrossRef]
21. LOO, C.Y. and SUDESH, K. (2007). Biosynthesis and native granule characteristics of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Delftia acidovorans. International Journal of Biological Macromolecules, vol. 40, no. 5, p. 466-471. [CrossRef]
22. MAO, S.; XU, J.; CAI, C.; GERMERSHAUS, O.; SCHAPER, A. and KISSEL, T. (2007). Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres. International Journal of Pharmaceutics, vol. 334, no. 1-2, p. 137-148. [CrossRef]
23. MITOMO, H.; TAKAHASHI, T.; ITO, H. and SAITO, T. (1999). Biosynthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Burkholderia cepacia D1. International Journal of Biological Macromolecules, vol. 24, no. 4, p. 311-318. [CrossRef]
24. OGAWA, Y.; YAMAMOTO, M.; TAKADA, S.; OKADA, H. and SHIMAMOTO, T. (1988). Controlled-release of leuprolide acetate from polylactic acid or copoly(lactic/glycolic) acid microcapsules: Influence of molecular weight and copolymer ratio of polymer. Chemical & Pharmaceutical Bulletin, vol. 36, no. 4, p. 1502-1507. [CrossRef]
25. PARK, S.J.; AHN, W.S.; GREEN, P.R. and LEE, S.Y. (2001). Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. Biotechnology and Bioengineering, vol. 74, no. 1, p. 82-87. [CrossRef]
26. SENDIL, D.; GÜRSEL, I.; WISE, D.L. and HASIRCI, V. (1999). Antibiotic release from biodegradable PHBV microparticles. Journal of Controlled Release, vol. 59, no. 2, p. 207-217. [CrossRef]
27. SIEPMANN, J.; FAISANT, N. and BENOIT, J.-P. (2002). A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations. Pharmaceutical Research, vol. 19, no. 12, p. 1885-1893. [CrossRef]
28. SUN, Y.; SCRUGGS, D.W.; PENG, Y.; JOHNSON, J.R. and SHUKLA, A.J. (2004). Issues and challenges in developing long-acting veterinary antibiotic formulations. Advanced Drug Delivery Reviews, vol. 56, no. 10, p. 1481-1496. [CrossRef]
29. SUSTRONCK, B.; DEPREZ, P.; MUYLLE, E.; VERMEERSCH, H.; VANDENBOSSCHE, G. and REMON, J.P. (1995). Evaluation of the nebulisation of sodium ceftiofur in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves. Research in Veterinary Science, vol. 59, no. 3, p. 267-271. [CrossRef]
30. TANG, S.; XIAO, J.; GUO, G.; HE, J.; HAO, Z. and XIAO, X. (2010). Preparation of a newly formulated long-acting ceftiofur hydrochloride suspension and evaluation of its pharmacokinetics in pigs. Journal of Veterinary Pharmacology and Therapeutics, vol. 33, no. 3, p. 238-245. [CrossRef]
31. VILOS, C. and VELASQUEZ, L.A. (2012). Therapeutic strategies based on polymeric microparticles. Journal of Biomedicine and Biotechnology, vol. 2012, no. 672760. [CrossRef]
32. VON BURKERSRODA, F.; SCHEDL, L. and GÖPFERICH, A. (2002). Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials, vol. 23, no. 21, p. 4221-4231. [CrossRef]
33. WALLMANN, J.; SCHRÖTER, K.; WIELER, L.H. and KROKER, R. (2003). National antibiotic resistance monitoring in veterinary pathogens from sick food-producing animals: The German programme and results from the 2001 pilot study. International Journal of Antimicrobial Agents, vol. 22, no. 4, p. 420-428. [CrossRef]
34. WANG, C.; YE, W.; ZHENG, Y.; LIU, X. and TONG, Z. (2007). Fabrication of drug-loaded biodegradable microcapsules for controlled release by combination of solvent evaporation and layer-by-layer self-assembly. International Journal of Pharmaceutics, vol. 338, no. 1-2, p. 165-173. [CrossRef]