Structural analysis of microparticles by confocal laser scanning microscopy

AAPS PharmSciTech

Volumn 1, Issue 3, 2000, Pages

  Lamprecht, Alf ^a   Schäfer, Ulrich ^a   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Confocal laser scanning microscopy (CLSM); Microencapsulation; Microparticles; Polymer distribution

Indexed keywords

ALGINIC ACID; BOVINE SERUM ALBUMIN; CASEIN; CHITOSAN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; GELATIN; ISOTHIOCYANIC ACID; POLYMER; RHODAMINE B; SOLVENT; MICROSPHERE;

ARTICLE; CHEMICAL COMPOSITION; COACERVATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG LABELING; EMULSION; ENCAPSULATION; EVAPORATION; GELATION; IMAGE ANALYSIS; MOLECULAR WEIGHT; PARTICLE SIZE; SAMPLING; SOLUBILITY; SPRAY DRYING; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG FORMULATION; METABOLISM; METHODOLOGY;

DRUG COMPOUNDING; EMULSIONS; MICROSCOPY, CONFOCAL; MICROSPHERES; POLYMERS;

EID: 23144450418     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt010317     Document Type: Article

References (22)

1. Arneodo C, Benoit JP, Thies C. Etude préliminaire de la microencapsulation d'huiles essentielles par coacervation complexe. STP Pharma Sciences. 1986; 2:303-306.
2. Benoit JP, Thies C. Microencapsulation - methods and industrial applications. In: Benita S, ed. Drugs and the Pharmaceutical Sciences. Vol. 73. New York: Marcel Dekker;1996.
3. Benita S, Benoit JP, Puisieux F, Thies C. Characterization of drug-loaded poly(d,l-lactide) microspheres. J Pharm Sci. 1984;73:1721-1724.
4. Mathews BR, Nixon JR. Surface characteristics of gelatin microcapsules by scanning electron microscopy. J Pharm Pharmacol. 1974;26:383-384.
5. Bodmeier R, McGinity J. Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. I. Methods and morphology. J Microencapsul. 1987;4:279-288.
6. Cutts LS, Hibberd S, Adler J, Davies MC, Melia CD. Characterising drug release processes within controlled release dosage forms using the confocal laser-scanning microscope. J Controlled Rel. 1996;42:115-124.
7. De Smedt SC, Meyvis TKL, Van Oostveldt P, Demeester J. A new microphotolysis based approach for mapping the mobility of drugs in microscopic drug delivery devices. Pharm Res. 1999;16:1639-1642.
8. Bouillot P, Babak V, Dellacherie E. Novel bioresorbable and bioeliminable surfactants for microsphere preparation. Pharm Res. 1999;16:148-154.
9. Adler J, Jayan A, Melia CD. A method for quantifying differential expansion within hydrating hydrophilic matrixes by tracking embedded fluorescent microspheres. J Pharm Sci. 1999;88:371-377.
10. Rojas J, Pinto-Alphandary H, Leo E, Pecquet S, Couvreur P, Gulik A, Fattal E. A polysorbate-based non-ionic surfactant can modulate loading and release of betalactoglobulin entrapped in multiphase poly(DL-lactide-co-glycolide) microspheres. Pharm Res. 1999;16:255-260.
11. Caponetti G, Hrkach JS, Kriwet B, Poh M, Lotan N, Colombo P, Langer R. Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization. J Pharm. Sci 1999;88:136-141.
12. Lamprecht A, Schäfer UF, Lehr, CM. Characterisation of microcapsules by confocal laser scanning microscopy: analysis of structure, capsule wall composition and of encapsulation rate. Eur J Pharm Biopharm. 2000;49:1-9.
13. Alex R, Bodmeier R. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. J Microencapsul. 1989;7:347-355.
14. Iwata M, McGinity JW. Preparation of multiphase microspheres of poly(lactic acid) and poly(lactic-co-glycolic acid) containing a W/O emulsion by a multiple solvent evaporation technique. J Microencapsul. 1992;9:201-214.
15. Schreiber AB, Haimovich J. Quantitative fluorometric assay for detection and characterization of Fc receptors. Meth Enzymol. 1983;93:147-155.
16. Luzzi LA, Gerraughty RJ. Effects of selected variables on the extractability of oils from coacervate capsules. J Pharm Sci. 1964;53:429-431.
17. Mussellwhite PR. The surface properties of an oil-water emulsion stabilized by mixtures of casein and gelatin. J Colloid and Interface Science. 1966;21:99-102.
18. Boury F, Ivanova T, Panaiotov I, Proust JE. Dilatational properties of adsorbed poly(D,Llactide) and bovine serum albumin monolayers at the dichloromethane/water interface. Langmuir. 1995;11:1636-1644.
19. Nihant N, Schugens C, Grandfils C, Jerome R, Teyssie P. Polylactide microparticles prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability. Pharm Res. 1994;11:1479-1484.
20. Sezer AD, Akbuga J. Release characteristics of chitosan treated alginate beads: I. Sustained release of a macromolecular drug from chitosan treated alginate beads. J Microencapsul. 1999;16:195-203.
21. Hari PR, Chandy T, Sharma CP. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J Microencapsul. 1996;13:319-329.
22. Murata Y, Toniwa S, Miyamoto E, Kawashima S. Preparation of alginate gel beads containing chitosan nicotinic acid salt and the functions. Eur J Pharm Biopharm. 1999;48:49-52.