Comparison of plasma pharmacokinetics and bioavailability of ceftiofur sodium and ceftiofur hydrochloride in pigs after a single intramuscular injection

Journal of Veterinary Pharmacology and Therapeutics

Volumn 22, Issue 1, 1999, Pages 35-40

  Brown, S A ^b,c   Hanson, B J ^b   Mignot, A ^a   Millerioux L ^a   Hamlow, P J ^b   Hubbard, V L ^b   Callahan, J K ^b   Kausche, F M ^b  

^a Cphac Laboratory   (France)

^b PFIZER INC   (United States)

^c Animal Health Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTIOFUR; CHLORIDE; DRUG METABOLITE; SODIUM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CEPHALOSPORINS; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; SWINE;

EID: 0032995983     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1999.00182.x     Document Type: Article

References (16)

1. Anonymous (1996) Bioequivalence Guidance (Final). Docket no. 94D-0401, Center for Veterinary Medicine, United States Food and Drug Administration.
2. Brown, S.A., Jaglan, P.S. & Banting, A. (1991a) Ceftiofur sodium: disposition, protein-binding, metabolism, and residue depletion profile in various species. Acta Veterinaria Scandinavica, 87 (Suppl.), 97-99.
3. Brown, S.A., Yancey, R.J. & Steffan, J. (1991b) Ceftiofur sodium: antimicrobial activity of parent ceftiofur and metabolites. Acta Veterinaria Scandinavica, 87 (Suppl.), 95-97.
4. Chow, S.-C. & Liu, J.P. (1992) Design and Analysis of Bioavailability and Bioequivalence Studies. pp. 70-125. Marcel Dekker, New York.
5. Eagle, H., Fleischman, R. & Levy, M. (1953) 'Continuous' vs. 'discontinuous' therapy with penicillin. The effect of the interval between injections on therapeutic efficacy. New England Journal of Medicine, 248, 481-488.
6. FDA (1988) Animal drugs, feed, and related products: ceftiofur sterile powder. Federal Register, 53, 5369-5370.
7. FDA (1991) Implantation or injectable dosage form: new animal health drugs not subject to certification: ceftiofur sterile powder. Federal Register, 56, 12119.
8. Frimodt-Møller, N., Bentzon, M.W. & Thomsen, V.F. (1986) Experimental infections with Streptococcus pneumoniae in mice: correlation of in vitro activity and pharmacokinetic parameters with in vivo effect for 14 cephalosporins. Journal of Infectious Diseases, 154, 511-517.
9. Frimodt-Møller, N., Bentzon, M.W. & Thomsen, V.F. (1987) Experimental pneumococcus infection in mice: comparative in vitro and in vivo effect of cefuroxime, cefotaxime and ceftriaxone. Acta Pathologica Microbiologica Immunologica Scandanavica, 95, (Section B) 261-267.
10. Gibaldi, M. & Perrier, D. (1982) Pharmacokinetics, 2nd edn. pp. 410-411. Marcel Dekker Inc, New York, NY.
11. Hamlow, P.J. (1995) HPLC analysis for the determination of ceftiofur residues in bovine and swine plasma, SOP 7926/289/09.a. Animal Health Drug Metabolism, OU 7926, Upjohn Laboratories, 22 February, 1995.
12. Jaglan, P.S., Cox, B.L., Arnold, T.S., Kubicek, M.F., Stewart, D.J. & Gilbertson, T.J. (1990) Liquid chromatographic determination of desfuroylceftiofur metabolite of ceftiofur as residue in cattle plasma. Journal of the Association of Official Analytical Chemists, 73, 26-30.
13. Joiner, K., Lowe, B., Dzink, J. & Bartlett, J.G. (1982) Comparative efficacy of 10 antimicrobial agents in experimental infections with Bacteroides fragilis. Journal of Infectious Diseases, 145, 561-568.
14. Kays, M.B., White, R.L., Friedrick, L.V. & Del Bene, V.E. (1991) Evaluation of cephalosporins/cephamycins with antianaerobic activity by integrating microbiologic and pharmacokinetic properties. Clinical Therapeutics, 13, 596-605.
15. Peterson, L.R., Gerding, D.N., Moody, J.A. & Fasching, C.E. (1984) Comparison of azlocillin, ceftizoxime, cefoxitin, and amikacin alone and in combination against Pseudomonas aeruginosa in a neutropenic-site rabbit model. Antimicrobial Agents and Chemotherapy, 25, 545-552.
16. Yancey, R.J., Kinney, M.L., Robert, B.J., Goodenough, K.R., Hamel, J.C. & Ford, C.W. (1987) Ceftiofur sodium, a broad spectrum cephalosporin: evaluation in vitro and in vivo in mice. American Journal of Veterinary Research, 48, 1050-1053.