Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: Towards individualized models of whole-body physiology

PLoS Computational Biology

Volumn 8, Issue 6, 2012, Pages

  Moss, Robert ^a,b,c   Grosse, Thibault ^a,b   Marchant, Ivanny ^d   Lassau, Nathalie ^a,b   Gueyffier, François ^e,f,g,h   Thomas, S Randall ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSIDAD DE VALPARAÍSO   (Chile)

^e IMTh Institute for Theoretical Medicine   (France)

^f UNIVERSITÉ LYON 1   (France)

^g INSERM   (France)

^h HOSPICES CIVILS DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE; FUNCTIONS; SENSITIVITY ANALYSIS;

BLOOD PRESSURE REGULATION; MULTI-SCALES; MULTIPARAMETERS; MULTISCALE MODELING; PARAMETER INTERACTIONS; PATHOPHYSIOLOGICAL; PHYSIOLOGICAL DATA; SYSTEMATIC ANALYSIS; VIRTUAL PATIENTS; WHOLE-BODY;

PHYSIOLOGICAL MODELS;

HYALURONIC ACID;

ARTERIOLE; ARTICLE; AUTOREGULATION; BLOOD PRESSURE REGULATION; COMPUTER MODEL; COMPUTER SIMULATION; DIASTOLIC BLOOD PRESSURE; GLOMERULUS FILTRATION; GUYTON MODEL; HEART OUTPUT; HEMATOCRIT; HYPERTENSION; INTERSTITIAL FLUID; MATHEMATICAL MODEL; MEAN ARTERIAL PRESSURE; MONTE CARLO METHOD; ONCOTIC PRESSURE; OXYGEN CONSUMPTION; PHENOTYPE; POTASSIUM INTAKE; PRESSURE GRADIENT; SENSITIVITY ANALYSIS; SODIUM EXCRETION; SODIUM INTAKE; STEADY STATE; SYSTOLIC BLOOD PRESSURE; VIRTUAL REALITY; BIOLOGICAL MODEL; BIOLOGY; BLOOD PRESSURE; COMPUTER INTERFACE; HUMAN; MICTURITION; PATHOPHYSIOLOGY; PERSONALIZED MEDICINE; PHYSIOLOGY; REPRODUCIBILITY;

BLOOD PRESSURE; CARDIAC OUTPUT; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HUMANS; HYPERTENSION; INDIVIDUALIZED MEDICINE; MODELS, CARDIOVASCULAR; MONTE CARLO METHOD; REPRODUCIBILITY OF RESULTS; URINATION; USER-COMPUTER INTERFACE;

EID: 84864050091     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002571     Document Type: Article

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