Equation-free analysis of two-component system signalling model reveals the emergence of co-existing phenotypes in the absence of multistationarity

PLoS Computational Biology

Volumn 8, Issue 6, 2012, Pages

  Hoyle, Rebecca B ^a   Avitabile, Daniele ^b   Kierzek, Andrzej M ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIFURCATION (MATHEMATICS); CHEMICAL ANALYSIS; EXCITED STATES; NUMERICAL METHODS; STOCHASTIC SYSTEMS;

BIOCHEMICAL PROCESS; CO-EXISTING; DETERMINISTICS; ENVIRONMENTAL CONDITIONS; EQUATION-FREE ANALYSIS; EXTERNAL SIGNALS; MIXED MODE; PHENOTYPIC DIFFERENCES; STOCHASTICITY; TWO COMPONENT SYSTEMS;

STOCHASTIC MODELS;

MESSENGER RNA; PROTEIN HISTIDINE KINASE; BACTERIAL PROTEIN; PHOB PROTEIN, BACTERIA; PHOR PROTEIN, BACTERIA;

ARTICLE; CELL POPULATION; ESCHERICHIA COLI; GENE; GENE CONTROL; GENE EXPRESSION PROFILING; HISTIDINE KINASE GENE; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; MOLECULAR INTERACTION; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; POSITIVE FEEDBACK; PROBABILITY; REGULATOR GENE; REPORTER GENE; RESPONSE REGULATOR GENE; SIGNAL TRANSDUCTION; STEADY STATE; STOCHASTIC MODEL; ALGORITHM; BACTERIUM; BIOLOGICAL MODEL; BIOLOGY; COMPUTER SIMULATION; GENETICS; KINETICS; METABOLISM; STATISTICS; SYSTEMS BIOLOGY;

ALGORITHMS; BACTERIA; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ESCHERICHIA COLI; KINETICS; MODELS, BIOLOGICAL; PHENOTYPE; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; SYSTEMS BIOLOGY;

EID: 84864048362     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002396     Document Type: Article

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