Determination of the permeability characteristics of two sulfenamide prodrugs of linezolid across Caco-2 cells

Journal of Pharmaceutical Sciences

Volumn 101, Issue 9, 2012, Pages 3134-3141

  Nti Addae, Kwame W ^a,b   Guarino, Victor R ^a,c   Dalwadi, Gautam ^a   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

Bioconversion; Caco 2 cells; MDCK cells; Permeability; Prodrugs; Stability; Sulfenamides

Indexed keywords

LINEZOLID; N (PHENYLTHIO)LINEZOLID; N [(2 ETHOXYCARBONYL)ETHYLTHIO]LINEZOLID; PRODRUG; SULFENAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG PENETRATION; DRUG STABILITY; IN VITRO STUDY; PH; TEMPERATURE;

EID: 84864041042     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23084     Document Type: Article

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