Physicochemical characterization and structural evaluation of a specific 2:1 cocrystal of naproxen-nicotinamide

Journal of Pharmaceutical Sciences

Volumn 101, Issue 9, 2012, Pages 3214-3221

  Ando, Shigeru ^a,b   Kikuchi, Junko ^a   Fujimura, Yuko ^a   Ida, Yasuo ^a   Higashi, Kenjirou ^b   Moribe, Kunikazu ^b   Yamamoto, Keiji ^b  

^a SHIONOGI AND CO LTD   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Cocrystal; Cross polarization (CP) heteronuclear correlation (HETCOR) NMR; Single crystal X ray analysis; Solid state NMR; Synthon

Indexed keywords

AMIDE; CARBON 13; CARBOXYLIC ACID; HYDROGEN; NAPROXEN; NICOTINAMIDE; PYRIDINE;

ADSORPTION; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SOLUBILITY; DRUG STRUCTURE; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; POLARIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID STATE; WATER VAPOR; WETTABILITY; X RAY ANALYSIS;

EID: 84864033935     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23158     Document Type: Article

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