메뉴 건너뛰기




Volumn 2, Issue 4, 2012, Pages

Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model

Author keywords

Bevacizumab; IL 2R null (NOG) mouse; Lymphoma; NOD Shi scid; Tumor microenvironment

Indexed keywords

BEVACIZUMAB; CYCLOPHOSPHAMIDE; DOXORUBICIN; INTERLEUKIN 2 RECEPTOR; PREDNISOLONE; VINCRISTINE;

EID: 84864026702     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2012.12     Document Type: Article
Times cited : (10)

References (40)
  • 2
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6: 273-286.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 3
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: 841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6
  • 4
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 5
    • 18344410760 scopus 로고    scopus 로고
    • NOD/SCID/ gcnull mouse: An excellent recipient mouse model for engraftment of human cells
    • Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K et al. NOD/SCID/ gcnull mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002; 100: 3175-3182.
    • (2002) Blood , vol.100 , pp. 3175-3182
    • Ito, M.1    Hiramatsu, H.2    Kobayashi, K.3    Suzue, K.4    Kawahata, M.5    Hioki, K.6
  • 6
    • 44449120863 scopus 로고    scopus 로고
    • NOD/Shi-scid IL2rgnull (NOG) micemore appropriate for humanized mouse models
    • Ito M, Kobayashi K, Nakahata T. NOD/Shi-scid IL2rgnull (NOG) micemore appropriate for humanized mouse models. Curr Top Microbiol Immunol 2008; 324: 53-76.
    • (2008) Curr Top Microbiol Immunol , vol.324 , pp. 53-76
    • Ito, M.1    Kobayashi, K.2    Nakahata, T.3
  • 7
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3    Hwu, P.4    Schwartzentruber, D.J.5    Topalian, S.L.6
  • 8
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 9
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxelcarboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A et al. Paclitaxelcarboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 10
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3    Dickler, M.4    Cobleigh, M.5    Perez, E.A.6
  • 12
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008; 26: 2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6
  • 13
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE Study
    • Hochster HS, Hart LL, Ramanathan RK, Childs BH, Hainsworth JD, Cohn AL et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. J Clin Oncol 2008; 26: 3523-3529.
    • (2008) J Clin Oncol , vol.26 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3    Childs, B.H.4    Hainsworth, J.D.5    Cohn, A.L.6
  • 14
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009; 27: 1227-1234.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6
  • 15
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the firstline treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, Cortés J, Pivot X, Tomczak P et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the firstline treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010; 28: 3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3    Cortés, J.4    Pivot, X.5    Tomczak, P.6
  • 16
    • 79955835059 scopus 로고    scopus 로고
    • Pathogenesis of non-Hodgkin's lymphoma
    • Nogai H, Dörken B, Lenz G. Pathogenesis of non-Hodgkin's lymphoma. J Clin Oncol 2011; 29: 1803-1811.
    • (2011) J Clin Oncol , vol.29 , pp. 1803-1811
    • Nogai, H.1    Dörken, B.2    Lenz, G.3
  • 17
    • 1842413105 scopus 로고    scopus 로고
    • A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project
    • A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 1997; 89: 3909-3918.
    • (1997) Blood , vol.89 , pp. 3909-3918
  • 18
    • 9144237554 scopus 로고    scopus 로고
    • Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
    • Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275-282.
    • (2004) Blood , vol.103 , pp. 275-282
    • Hans, C.P.1    Weisenburger, D.D.2    Greiner, T.C.3    Gascoyne, R.D.4    Delabie, J.5    Ott, G.6
  • 20
    • 9344251670 scopus 로고    scopus 로고
    • The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma
    • Ishida T, Iida S, Akatsuka Y, Ishii T, Miyazaki M, Komatsu H et al. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma. Clin Cancer Res 2004; 10: 7529-7539.
    • (2004) Clin Cancer Res , vol.10 , pp. 7529-7539
    • Ishida, T.1    Iida, S.2    Akatsuka, Y.3    Ishii, T.4    Miyazaki, M.5    Komatsu, H.6
  • 21
    • 0034486490 scopus 로고    scopus 로고
    • The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model
    • Mohammad RM, Wall NR, Dutcher JA, Al-Katib AM. The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. Clin Cancer Res 2000; 6: 4950-4956.
    • (2000) Clin Cancer Res , vol.6 , pp. 4950-4956
    • Mohammad, R.M.1    Wall, N.R.2    Dutcher, J.A.3    Al-Katib, A.M.4
  • 22
    • 0027252110 scopus 로고
    • The IL-2/IL-2 receptor system: A target for rational immune intervention
    • Waldmann TA. The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol Today 1993; 14: 264-270.
    • (1993) Immunol Today , vol.14 , pp. 264-270
    • Waldmann, T.A.1
  • 23
    • 67349223517 scopus 로고    scopus 로고
    • Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model
    • Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F et al. Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol Immunother 2009; 58: 1195-1206.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1195-1206
    • Ito, A.1    Ishida, T.2    Yano, H.3    Inagaki, A.4    Suzuki, S.5    Sato, F.6
  • 24
    • 70449711386 scopus 로고    scopus 로고
    • Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo
    • Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H et al. Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J Immunol 2009; 183: 4782-4791.
    • (2009) J Immunol , vol.183 , pp. 4782-4791
    • Ito, A.1    Ishida, T.2    Utsunomiya, A.3    Sato, F.4    Mori, F.5    Yano, H.6
  • 25
    • 7244236494 scopus 로고    scopus 로고
    • Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
    • Wang ES, Teruya-Feldstein J, Wu Y, Zhu Z, Hicklin DJ, Moore MA. Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo. Blood 2004; 104: 2893-2902.
    • (2004) Blood , vol.104 , pp. 2893-2902
    • Wang, E.S.1    Teruya-Feldstein, J.2    Wu, Y.3    Zhu, Z.4    Hicklin, D.J.5    Moore, M.A.6
  • 26
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgström P, Hillan KJ, Sriramarao P, Ferrara N. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res 1996; 56: 4032-4039.
    • (1996) Cancer Res , vol.56 , pp. 4032-4039
    • Borgström, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 27
    • 61649123322 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma
    • Ruan J, Hajjar K, Rafii S, Leonard JP. Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma. Ann Oncol 2009; 20: 413-424.
    • (2009) Ann Oncol , vol.20 , pp. 413-424
    • Ruan, J.1    Hajjar, K.2    Rafii, S.3    Leonard, J.P.4
  • 29
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008; 8: 579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 30
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 31
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005; 65: 671-680.
    • (2005) Cancer Res , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 32
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011; 10: 417-427.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 33
    • 33746290180 scopus 로고    scopus 로고
    • Rituximab, Bevacizumab and CHOP (RA-CHOP) in untreated diffuse large B-cell lymphoma: Safety, biomarker and pharmacokinetic analysis
    • Ganjoo KN, An CS, Robertson MJ, Gordon LI, Sen JA, Weisenbach J et al. Rituximab, Bevacizumab and CHOP (RA-CHOP) in untreated diffuse large B-cell lymphoma: safety, biomarker and pharmacokinetic analysis. Leuk Lymphoma 2006; 47: 998-1005.
    • (2006) Leuk Lymphoma , vol.47 , pp. 998-1005
    • Ganjoo, K.N.1    An, C.S.2    Robertson, M.J.3    Gordon, L.I.4    Sen, J.A.5    Weisenbach, J.6
  • 34
    • 34247897170 scopus 로고    scopus 로고
    • Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes
    • Gratzinger D, Zhao S, Marinelli RJ, Kapp AV, Tibshirani RJ, Hammer AS et al. Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes. Am J Pathol 2007; 170: 1362-1369.
    • (2007) Am J Pathol , vol.170 , pp. 1362-1369
    • Gratzinger, D.1    Zhao, S.2    Marinelli, R.J.3    Kapp, A.V.4    Tibshirani, R.J.5    Hammer, A.S.6
  • 35
    • 67650866822 scopus 로고    scopus 로고
    • A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108
    • Stopeck AT, Unger JM, Rimsza LM, Bellamy WT, Iannone M, Persky DO et al. A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108. Leuk Lymphoma 2009; 50: 728-735.
    • (2009) Leuk Lymphoma , vol.50 , pp. 728-735
    • Stopeck, A.T.1    Unger, J.M.2    Rimsza, L.M.3    Bellamy, W.T.4    Iannone, M.5    Persky, D.O.6
  • 36
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced nonsmall-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced nonsmall-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005; 366: 1527-1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5    Von Pawel, J.6
  • 37
  • 38
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 39
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 40
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261.
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.